Polygonum viviparum L. inhibits the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through haem oxygenase-1 induction and activation of the Nrf2 pathway
BACKGROUND: Polygonum viviparum L. (PV) is a member of the family Polygonaceae and is widely distributed in high‐elevation areas. It is used as a folk remedy to treat inflammation‐related diseases. This study was focused on the anti‐inflammatory response of PV against lipopolysaccharide (LPS)‐induce...
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| Veröffentlicht in: | Journal of the science of food and agriculture 2013-02, Vol.93 (3), p.491-497 |
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| container_title | Journal of the science of food and agriculture |
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| creator | Cheng, Hui-Wen Lee, Kock-Chee Cheah, Khoot-Peng Chang, Ming-Long Lin, Che-Wei Li, Joe-Sharg Yu, Wen-Yu Liu, E-Tung Hu, Chien-Ming |
| description | BACKGROUND: Polygonum viviparum L. (PV) is a member of the family Polygonaceae and is widely distributed in high‐elevation areas. It is used as a folk remedy to treat inflammation‐related diseases. This study was focused on the anti‐inflammatory response of PV against lipopolysaccharide (LPS)‐induced inflammation in RAW264.7 macrophages.
RESULTS: Treatment with PV did not cause cytotoxicity at 0–50 µg mL−1 in RAW264.7 macrophages, and the IC50 value was 270 µg mL−1. PV inhibited LPS‐stimulated nitric oxide (NO), prostaglandin (PG)E2, interleukin (IL)‐1β and tumour necrosis factor (TNF)‐α release and inducible NO synthase (iNOS) and cyclooxygenase (COX)‐2 protein expression. In addition, PV suppressed the LPS‐induced p65 expression of nuclear factor (NF)‐κB, which is associated with the inhibition of IκB‐α degradation. These results suggest that, among mechanisms of the anti‐inflammatory response, PV inhibits the production of NO and these cytokines by down‐regulating iNOS and COX‐2 gene expression. Furthermore, PV can induce haem oxygenase (HO)‐1 protein expression through nuclear factor E2‐related factor 2 (Nrf2) activation. A specific inhibitor of HO‐1, zinc(II) protoporphyrin IX, inhibited the suppression of iNOS and COX‐2 expression by PV.
CONCLUSION: These results suggest that PV possesses anti‐inflammatory actions in macrophages and works through a novel mechanism involving Nrf2 actions and HO‐1. Thus PV could be considered for application as a potential therapeutic approach for inflammation‐associated disorders. © 2012 Society of Chemical Industry |
| doi_str_mv | 10.1002/jsfa.5795 |
| format | Article |
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RESULTS: Treatment with PV did not cause cytotoxicity at 0–50 µg mL−1 in RAW264.7 macrophages, and the IC50 value was 270 µg mL−1. PV inhibited LPS‐stimulated nitric oxide (NO), prostaglandin (PG)E2, interleukin (IL)‐1β and tumour necrosis factor (TNF)‐α release and inducible NO synthase (iNOS) and cyclooxygenase (COX)‐2 protein expression. In addition, PV suppressed the LPS‐induced p65 expression of nuclear factor (NF)‐κB, which is associated with the inhibition of IκB‐α degradation. These results suggest that, among mechanisms of the anti‐inflammatory response, PV inhibits the production of NO and these cytokines by down‐regulating iNOS and COX‐2 gene expression. Furthermore, PV can induce haem oxygenase (HO)‐1 protein expression through nuclear factor E2‐related factor 2 (Nrf2) activation. A specific inhibitor of HO‐1, zinc(II) protoporphyrin IX, inhibited the suppression of iNOS and COX‐2 expression by PV.
CONCLUSION: These results suggest that PV possesses anti‐inflammatory actions in macrophages and works through a novel mechanism involving Nrf2 actions and HO‐1. Thus PV could be considered for application as a potential therapeutic approach for inflammation‐associated disorders. © 2012 Society of Chemical Industry</description><identifier>ISSN: 0022-5142</identifier><identifier>EISSN: 1097-0010</identifier><identifier>DOI: 10.1002/jsfa.5795</identifier><identifier>PMID: 23129114</identifier><identifier>CODEN: JSFAAE</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; Anti-Inflammatory Agents ; Cell Line ; Cell Survival - drug effects ; Cyclooxygenase 2 - genetics ; Cyclooxygenase Inhibitors - pharmacology ; Cytokines ; Cytotoxicity ; Enzyme Induction - drug effects ; Flowers & plants ; Gene expression ; haem oxygenase-1 ; Heme Oxygenase-1 - biosynthesis ; Inflammation - chemically induced ; Inflammation - prevention & control ; lipopolysaccharide ; Lipopolysaccharides - pharmacology ; Macrophages - drug effects ; Macrophages - enzymology ; Mice ; NF-E2-Related Factor 2 - drug effects ; NF-E2-Related Factor 2 - physiology ; Nitric oxide ; Nitric Oxide Synthase Type II - antagonists & inhibitors ; Nitric Oxide Synthase Type II - genetics ; nuclear factor E2-related factor 2 ; Plant Extracts - pharmacology ; Polygonum - chemistry ; Polygonum viviparum L ; RAW264.7 macrophages ; TNF inhibitors</subject><ispartof>Journal of the science of food and agriculture, 2013-02, Vol.93 (3), p.491-497</ispartof><rights>Copyright © 2012 Society of Chemical Industry</rights><rights>Copyright © 2012 Society of Chemical Industry.</rights><rights>Copyright John Wiley and Sons, Limited Feb 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3915-14dc01de2af413e64305c7722c283d4a1a8564c12288a0fcbeb4752504c57a213</citedby><cites>FETCH-LOGICAL-c3915-14dc01de2af413e64305c7722c283d4a1a8564c12288a0fcbeb4752504c57a213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjsfa.5795$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjsfa.5795$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23129114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Hui-Wen</creatorcontrib><creatorcontrib>Lee, Kock-Chee</creatorcontrib><creatorcontrib>Cheah, Khoot-Peng</creatorcontrib><creatorcontrib>Chang, Ming-Long</creatorcontrib><creatorcontrib>Lin, Che-Wei</creatorcontrib><creatorcontrib>Li, Joe-Sharg</creatorcontrib><creatorcontrib>Yu, Wen-Yu</creatorcontrib><creatorcontrib>Liu, E-Tung</creatorcontrib><creatorcontrib>Hu, Chien-Ming</creatorcontrib><title>Polygonum viviparum L. inhibits the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through haem oxygenase-1 induction and activation of the Nrf2 pathway</title><title>Journal of the science of food and agriculture</title><addtitle>J. Sci. Food Agric</addtitle><description>BACKGROUND: Polygonum viviparum L. (PV) is a member of the family Polygonaceae and is widely distributed in high‐elevation areas. It is used as a folk remedy to treat inflammation‐related diseases. This study was focused on the anti‐inflammatory response of PV against lipopolysaccharide (LPS)‐induced inflammation in RAW264.7 macrophages.
RESULTS: Treatment with PV did not cause cytotoxicity at 0–50 µg mL−1 in RAW264.7 macrophages, and the IC50 value was 270 µg mL−1. PV inhibited LPS‐stimulated nitric oxide (NO), prostaglandin (PG)E2, interleukin (IL)‐1β and tumour necrosis factor (TNF)‐α release and inducible NO synthase (iNOS) and cyclooxygenase (COX)‐2 protein expression. In addition, PV suppressed the LPS‐induced p65 expression of nuclear factor (NF)‐κB, which is associated with the inhibition of IκB‐α degradation. These results suggest that, among mechanisms of the anti‐inflammatory response, PV inhibits the production of NO and these cytokines by down‐regulating iNOS and COX‐2 gene expression. Furthermore, PV can induce haem oxygenase (HO)‐1 protein expression through nuclear factor E2‐related factor 2 (Nrf2) activation. A specific inhibitor of HO‐1, zinc(II) protoporphyrin IX, inhibited the suppression of iNOS and COX‐2 expression by PV.
CONCLUSION: These results suggest that PV possesses anti‐inflammatory actions in macrophages and works through a novel mechanism involving Nrf2 actions and HO‐1. Thus PV could be considered for application as a potential therapeutic approach for inflammation‐associated disorders. © 2012 Society of Chemical Industry</description><subject>Animals</subject><subject>Anti-Inflammatory Agents</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>Cyclooxygenase 2 - genetics</subject><subject>Cyclooxygenase Inhibitors - pharmacology</subject><subject>Cytokines</subject><subject>Cytotoxicity</subject><subject>Enzyme Induction - drug effects</subject><subject>Flowers & plants</subject><subject>Gene expression</subject><subject>haem oxygenase-1</subject><subject>Heme Oxygenase-1 - biosynthesis</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - prevention & control</subject><subject>lipopolysaccharide</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - enzymology</subject><subject>Mice</subject><subject>NF-E2-Related Factor 2 - drug effects</subject><subject>NF-E2-Related Factor 2 - physiology</subject><subject>Nitric oxide</subject><subject>Nitric Oxide Synthase Type II - antagonists & inhibitors</subject><subject>Nitric Oxide Synthase Type II - genetics</subject><subject>nuclear factor E2-related factor 2</subject><subject>Plant Extracts - pharmacology</subject><subject>Polygonum - chemistry</subject><subject>Polygonum viviparum L</subject><subject>RAW264.7 macrophages</subject><subject>TNF inhibitors</subject><issn>0022-5142</issn><issn>1097-0010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFv0zAUxy0EYmVw4AsgS1zgkM524jg5VhUboG5MDLSJi_XqOI1LEgc76ZavxSfEacsOSJz8bP_eT0_vj9BrSuaUEHa29SXMucj5EzSjJBcRIZQ8RbPwxyJOE3aCXni_JYTkeZo-RycspiynNJmh39e2Hje2HRq8MzvTgQvVao5NW5m16T3uK41r09kucB6UqsCZQkemLQali8CVNTQN9NaN2Gnf2dbr8Iq_Lm5ZmswFbkA521Ww0ZPM2WFT4Qp0g-3DuNEteB1RvNf1xrYY2gJDKHewv9pyP8GVKxnuoK_uYXyJnpVQe_3qeJ6i7-cfvi0_RqsvF5-Wi1Wk4pzyiCaFIrTQDMqExjpNYsKVEIwplsVFAhQyniaKMpZlQEq11utEcMZJorgARuNT9O7g7Zz9NWjfy8Z4pesaWm0HLynLWFiuoGlA3_6Dbu3g2jDdRMWECJ7mgXp_oMJCvHe6lJ0zDbhRUiKnIOUUpJyCDOybo3FYN7p4JP8mF4CzA3Bvaj3-3yQ_35wvjsro0GF8rx8eO8D9lKmIBZe3Vxfyhi1_XN9d3snL-A-SuLlD</recordid><startdate>201302</startdate><enddate>201302</enddate><creator>Cheng, Hui-Wen</creator><creator>Lee, Kock-Chee</creator><creator>Cheah, Khoot-Peng</creator><creator>Chang, Ming-Long</creator><creator>Lin, Che-Wei</creator><creator>Li, Joe-Sharg</creator><creator>Yu, Wen-Yu</creator><creator>Liu, E-Tung</creator><creator>Hu, Chien-Ming</creator><general>John Wiley & Sons, Ltd</general><general>John Wiley and Sons, Limited</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QL</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>201302</creationdate><title>Polygonum viviparum L. inhibits the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through haem oxygenase-1 induction and activation of the Nrf2 pathway</title><author>Cheng, Hui-Wen ; Lee, Kock-Chee ; Cheah, Khoot-Peng ; Chang, Ming-Long ; Lin, Che-Wei ; Li, Joe-Sharg ; Yu, Wen-Yu ; Liu, E-Tung ; Hu, Chien-Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3915-14dc01de2af413e64305c7722c283d4a1a8564c12288a0fcbeb4752504c57a213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents</topic><topic>Cell Line</topic><topic>Cell Survival - drug effects</topic><topic>Cyclooxygenase 2 - genetics</topic><topic>Cyclooxygenase Inhibitors - pharmacology</topic><topic>Cytokines</topic><topic>Cytotoxicity</topic><topic>Enzyme Induction - drug effects</topic><topic>Flowers & plants</topic><topic>Gene expression</topic><topic>haem oxygenase-1</topic><topic>Heme Oxygenase-1 - biosynthesis</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - prevention & control</topic><topic>lipopolysaccharide</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - enzymology</topic><topic>Mice</topic><topic>NF-E2-Related Factor 2 - drug effects</topic><topic>NF-E2-Related Factor 2 - physiology</topic><topic>Nitric oxide</topic><topic>Nitric Oxide Synthase Type II - antagonists & inhibitors</topic><topic>Nitric Oxide Synthase Type II - genetics</topic><topic>nuclear factor E2-related factor 2</topic><topic>Plant Extracts - pharmacology</topic><topic>Polygonum - chemistry</topic><topic>Polygonum viviparum L</topic><topic>RAW264.7 macrophages</topic><topic>TNF inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Hui-Wen</creatorcontrib><creatorcontrib>Lee, Kock-Chee</creatorcontrib><creatorcontrib>Cheah, Khoot-Peng</creatorcontrib><creatorcontrib>Chang, Ming-Long</creatorcontrib><creatorcontrib>Lin, Che-Wei</creatorcontrib><creatorcontrib>Li, Joe-Sharg</creatorcontrib><creatorcontrib>Yu, Wen-Yu</creatorcontrib><creatorcontrib>Liu, E-Tung</creatorcontrib><creatorcontrib>Hu, Chien-Ming</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the science of food and agriculture</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Hui-Wen</au><au>Lee, Kock-Chee</au><au>Cheah, Khoot-Peng</au><au>Chang, Ming-Long</au><au>Lin, Che-Wei</au><au>Li, Joe-Sharg</au><au>Yu, Wen-Yu</au><au>Liu, E-Tung</au><au>Hu, Chien-Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polygonum viviparum L. inhibits the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through haem oxygenase-1 induction and activation of the Nrf2 pathway</atitle><jtitle>Journal of the science of food and agriculture</jtitle><addtitle>J. Sci. Food Agric</addtitle><date>2013-02</date><risdate>2013</risdate><volume>93</volume><issue>3</issue><spage>491</spage><epage>497</epage><pages>491-497</pages><issn>0022-5142</issn><eissn>1097-0010</eissn><coden>JSFAAE</coden><abstract>BACKGROUND: Polygonum viviparum L. (PV) is a member of the family Polygonaceae and is widely distributed in high‐elevation areas. It is used as a folk remedy to treat inflammation‐related diseases. This study was focused on the anti‐inflammatory response of PV against lipopolysaccharide (LPS)‐induced inflammation in RAW264.7 macrophages.
RESULTS: Treatment with PV did not cause cytotoxicity at 0–50 µg mL−1 in RAW264.7 macrophages, and the IC50 value was 270 µg mL−1. PV inhibited LPS‐stimulated nitric oxide (NO), prostaglandin (PG)E2, interleukin (IL)‐1β and tumour necrosis factor (TNF)‐α release and inducible NO synthase (iNOS) and cyclooxygenase (COX)‐2 protein expression. In addition, PV suppressed the LPS‐induced p65 expression of nuclear factor (NF)‐κB, which is associated with the inhibition of IκB‐α degradation. These results suggest that, among mechanisms of the anti‐inflammatory response, PV inhibits the production of NO and these cytokines by down‐regulating iNOS and COX‐2 gene expression. Furthermore, PV can induce haem oxygenase (HO)‐1 protein expression through nuclear factor E2‐related factor 2 (Nrf2) activation. A specific inhibitor of HO‐1, zinc(II) protoporphyrin IX, inhibited the suppression of iNOS and COX‐2 expression by PV.
CONCLUSION: These results suggest that PV possesses anti‐inflammatory actions in macrophages and works through a novel mechanism involving Nrf2 actions and HO‐1. Thus PV could be considered for application as a potential therapeutic approach for inflammation‐associated disorders. © 2012 Society of Chemical Industry</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>23129114</pmid><doi>10.1002/jsfa.5795</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of the science of food and agriculture, 2013-02, Vol.93 (3), p.491-497 |
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| subjects | Animals Anti-Inflammatory Agents Cell Line Cell Survival - drug effects Cyclooxygenase 2 - genetics Cyclooxygenase Inhibitors - pharmacology Cytokines Cytotoxicity Enzyme Induction - drug effects Flowers & plants Gene expression haem oxygenase-1 Heme Oxygenase-1 - biosynthesis Inflammation - chemically induced Inflammation - prevention & control lipopolysaccharide Lipopolysaccharides - pharmacology Macrophages - drug effects Macrophages - enzymology Mice NF-E2-Related Factor 2 - drug effects NF-E2-Related Factor 2 - physiology Nitric oxide Nitric Oxide Synthase Type II - antagonists & inhibitors Nitric Oxide Synthase Type II - genetics nuclear factor E2-related factor 2 Plant Extracts - pharmacology Polygonum - chemistry Polygonum viviparum L RAW264.7 macrophages TNF inhibitors |
| title | Polygonum viviparum L. inhibits the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through haem oxygenase-1 induction and activation of the Nrf2 pathway |
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