Light and electron microscopy of classical Ehlers-Danlos syndrome
A 12-year-old boy with difficulty in wound healing and abnormal scars since early childhood was examined. Light microscopy showed loose and disperse dermal collagen with rare bundles, and fibroblasts show an irregular morphology. The fibrous sheath of hair presented a normal parallel distribution of...
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| Veröffentlicht in: | The American journal of dermatopathology 2013-02, Vol.35 (1), p.102-105 |
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| container_title | The American journal of dermatopathology |
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| creator | de Almeida, Jr, Hiram L Bicca, Eduardo Rocha, Nara M de Castro, Luis A S |
| description | A 12-year-old boy with difficulty in wound healing and abnormal scars since early childhood was examined. Light microscopy showed loose and disperse dermal collagen with rare bundles, and fibroblasts show an irregular morphology. The fibrous sheath of hair presented a normal parallel distribution of the collagen fibers with normal spindle-shaped fibroblasts. Transmission electron microscopy also found disorganized collagen fibers, which were seen in a same field in longitudinal and cross sections. With high magnifications, an amorphous substance was seen near to loose collagen fibers, which showed variable diameters in cross sections. Scanning electron microscopy of the dermis showed disorganized collagen fibers and with higher magnification, important collagen disarrangement was observed with isolated and crossed-over fibers. |
| doi_str_mv | 10.1097/DAD.0b013e3182713293 |
| format | Article |
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Light microscopy showed loose and disperse dermal collagen with rare bundles, and fibroblasts show an irregular morphology. The fibrous sheath of hair presented a normal parallel distribution of the collagen fibers with normal spindle-shaped fibroblasts. Transmission electron microscopy also found disorganized collagen fibers, which were seen in a same field in longitudinal and cross sections. With high magnifications, an amorphous substance was seen near to loose collagen fibers, which showed variable diameters in cross sections. Scanning electron microscopy of the dermis showed disorganized collagen fibers and with higher magnification, important collagen disarrangement was observed with isolated and crossed-over fibers.</description><identifier>ISSN: 0193-1091</identifier><identifier>EISSN: 1533-0311</identifier><identifier>DOI: 10.1097/DAD.0b013e3182713293</identifier><identifier>PMID: 23051630</identifier><language>eng</language><publisher>United States</publisher><subject>Biopsy ; Child ; Cicatrix - pathology ; Dermis - ultrastructure ; Ehlers-Danlos Syndrome - pathology ; Fibrillar Collagens - ultrastructure ; Humans ; Male ; Microscopy, Electron, Scanning ; Microscopy, Electron, Transmission ; Phenotype ; Predictive Value of Tests ; Staining and Labeling ; Wound Healing</subject><ispartof>The American journal of dermatopathology, 2013-02, Vol.35 (1), p.102-105</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c307t-2144df5a79a6d72e82fa533dd81e727e64ff8fde63db12557592efe88cb8a0ee3</citedby><cites>FETCH-LOGICAL-c307t-2144df5a79a6d72e82fa533dd81e727e64ff8fde63db12557592efe88cb8a0ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23051630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Almeida, Jr, Hiram L</creatorcontrib><creatorcontrib>Bicca, Eduardo</creatorcontrib><creatorcontrib>Rocha, Nara M</creatorcontrib><creatorcontrib>de Castro, Luis A S</creatorcontrib><title>Light and electron microscopy of classical Ehlers-Danlos syndrome</title><title>The American journal of dermatopathology</title><addtitle>Am J Dermatopathol</addtitle><description>A 12-year-old boy with difficulty in wound healing and abnormal scars since early childhood was examined. Light microscopy showed loose and disperse dermal collagen with rare bundles, and fibroblasts show an irregular morphology. The fibrous sheath of hair presented a normal parallel distribution of the collagen fibers with normal spindle-shaped fibroblasts. Transmission electron microscopy also found disorganized collagen fibers, which were seen in a same field in longitudinal and cross sections. With high magnifications, an amorphous substance was seen near to loose collagen fibers, which showed variable diameters in cross sections. Scanning electron microscopy of the dermis showed disorganized collagen fibers and with higher magnification, important collagen disarrangement was observed with isolated and crossed-over fibers.</description><subject>Biopsy</subject><subject>Child</subject><subject>Cicatrix - pathology</subject><subject>Dermis - ultrastructure</subject><subject>Ehlers-Danlos Syndrome - pathology</subject><subject>Fibrillar Collagens - ultrastructure</subject><subject>Humans</subject><subject>Male</subject><subject>Microscopy, Electron, Scanning</subject><subject>Microscopy, Electron, Transmission</subject><subject>Phenotype</subject><subject>Predictive Value of Tests</subject><subject>Staining and Labeling</subject><subject>Wound Healing</subject><issn>0193-1091</issn><issn>1533-0311</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkD1PwzAQhi0EoqXwDxDKyJLis-PYGau2fEiVWGCOHPtMg5y42OnQf08qCgPTLc97d-9DyC3QOdBKPqwWqzltKHDkoJgEzip-RqYgOM8pBzgnUwoVz0cYJuQqpU9KgSkqLsmEcSqg5HRKFpv2YztkurcZejRDDH3WtSaGZMLukAWXGa9Tao322XrrMaZ8pXsfUpYOvY2hw2ty4bRPeHOaM_L-uH5bPueb16eX5WKTG07lkDMoCuuElpUurWSomNPjq9YqQMkkloVzylksuW2ACSFFxdChUqZRmiLyGbn_2buL4WuPaai7Nhn0XvcY9qkeuzFaqIKXI1r8oMceKaKrd7HtdDzUQOujvHqUV_-XN8buThf2TYf2L_Rri38DqMFqyg</recordid><startdate>201302</startdate><enddate>201302</enddate><creator>de Almeida, Jr, Hiram L</creator><creator>Bicca, Eduardo</creator><creator>Rocha, Nara M</creator><creator>de Castro, Luis A S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201302</creationdate><title>Light and electron microscopy of classical Ehlers-Danlos syndrome</title><author>de Almeida, Jr, Hiram L ; Bicca, Eduardo ; Rocha, Nara M ; de Castro, Luis A S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-2144df5a79a6d72e82fa533dd81e727e64ff8fde63db12557592efe88cb8a0ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Biopsy</topic><topic>Child</topic><topic>Cicatrix - pathology</topic><topic>Dermis - ultrastructure</topic><topic>Ehlers-Danlos Syndrome - pathology</topic><topic>Fibrillar Collagens - ultrastructure</topic><topic>Humans</topic><topic>Male</topic><topic>Microscopy, Electron, Scanning</topic><topic>Microscopy, Electron, Transmission</topic><topic>Phenotype</topic><topic>Predictive Value of Tests</topic><topic>Staining and Labeling</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Almeida, Jr, Hiram L</creatorcontrib><creatorcontrib>Bicca, Eduardo</creatorcontrib><creatorcontrib>Rocha, Nara M</creatorcontrib><creatorcontrib>de Castro, Luis A S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of dermatopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Almeida, Jr, Hiram L</au><au>Bicca, Eduardo</au><au>Rocha, Nara M</au><au>de Castro, Luis A S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Light and electron microscopy of classical Ehlers-Danlos syndrome</atitle><jtitle>The American journal of dermatopathology</jtitle><addtitle>Am J Dermatopathol</addtitle><date>2013-02</date><risdate>2013</risdate><volume>35</volume><issue>1</issue><spage>102</spage><epage>105</epage><pages>102-105</pages><issn>0193-1091</issn><eissn>1533-0311</eissn><abstract>A 12-year-old boy with difficulty in wound healing and abnormal scars since early childhood was examined. 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| identifier | ISSN: 0193-1091 |
| ispartof | The American journal of dermatopathology, 2013-02, Vol.35 (1), p.102-105 |
| issn | 0193-1091 1533-0311 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Biopsy Child Cicatrix - pathology Dermis - ultrastructure Ehlers-Danlos Syndrome - pathology Fibrillar Collagens - ultrastructure Humans Male Microscopy, Electron, Scanning Microscopy, Electron, Transmission Phenotype Predictive Value of Tests Staining and Labeling Wound Healing |
| title | Light and electron microscopy of classical Ehlers-Danlos syndrome |
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