Aromatic Bis‑N‑hydroxyguanidinium Derivatives: Synthesis, Biophysical, and Biochemical Evaluations

In this paper we report the synthesis of a new family of hydroxyguanidinium aromatic derivatives (4a–g) as potential minor groove binders and cytotoxic agents. Their DNA affinity was evaluated by thermal denaturation experiments using salmon sperm DNA. The antiproliferative effects of derivatives 4a...

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Veröffentlicht in:	Journal of medicinal chemistry 2013-01, Vol.56 (2), p.451-459
Hauptverfasser:	Kahvedžić, Amila, Nathwani, Seema-Maria, Zisterer, Daniela M, Rozas, Isabel
Format:	Artikel
Sprache:	eng
Schlagworte:	Biophysics Cell Line Guanidines - chemical synthesis Guanidines - chemistry Guanidines - metabolism Humans Magnetic Resonance Spectroscopy Mass Spectrometry
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