Oral supplementation with 25(OH)D3 versus vitamin D3: Effects on 25(OH)D levels, lower extremity function, blood pressure, and markers of innate immunity
To test the effect of 25(OH)D3 (HyD) compared to vitamin D3 on serum 25‐hydroxyvitamin D levels (25(OH)D), lower extremity function, blood pressure, and markers of innate immunity. Twenty healthy postmenopausal women with an average 25(OH)D level of 13.2 ± 3.9 ng/mL (mean ± SD) and a mean age of 61....
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| Veröffentlicht in: | Journal of bone and mineral research 2012-01, Vol.27 (1), p.160-169 |
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| creator | Bischoff-Ferrari, Heike Annette Dawson-Hughes, Bess Stöcklin, Elisabeth Sidelnikov, Eduard Willett, Walter Churchill Edel, John Orav Stähelin, Hannes Balthasar Wolfram, Swen Jetter, Alexander Schwager, Joseph Henschkowski, Jana von Eckardstein, Arnold Egli, Andreas |
| description | To test the effect of 25(OH)D3 (HyD) compared to vitamin D3 on serum 25‐hydroxyvitamin D levels (25(OH)D), lower extremity function, blood pressure, and markers of innate immunity. Twenty healthy postmenopausal women with an average 25(OH)D level of 13.2 ± 3.9 ng/mL (mean ± SD) and a mean age of 61.5 ± 7.2 years were randomized to either 20 µg of HyD or 20 µg (800 IU) of vitamin D3 per day in a double‐blind manner. We measured on 14 visits over 4 months, 25(OH)D serum levels, blood pressure, and seven markers of innate immunity (eotaxin, interleukin [IL]‐8, IL‐12, interferon gamma‐induced protein 10 kDa [IP‐10], monocyte chemotactic protein‐1 [MCP‐1], macrophage inflammatory protein beta [MIP‐1β], and “Regulated upon Activation, Normal T‐cell Expressed, and Secreted” [RANTES]). At baseline and at 4 months, a test battery for lower extremity function (knee extensor and flexor strength, timed up and go, repeated sit‐to‐stand) was assessed. All analyses were adjusted for baseline measurement, age, and body mass index. Mean 25(OH)D levels increased to 69.5 ng/mL in the HyD group. This rise was immediate and sustained. Mean 25(OH)D levels increased to 31.0 ng/mL with a slow increase in the vitamin D3 group. Women on HyD compared with vitamin D3 had a 2.8‐fold increased odds of maintained or improved lower extremity function (odds ratio [OR] = 2.79; 95% confidence interval [CI], 1.18–6.58), and a 5.7‐mmHg decrease in systolic blood pressure (p = 0.0002). Both types of vitamin D contributed to a decrease in five out of seven markers of innate immunity, significantly more pronounced with HyD for eotaxin, IL‐12, MCP‐1, and MIP‐1 β. There were no cases of hypercalcemia at any time point. Twenty micrograms (20 µg) of HyD per day resulted in a safe, immediate, and sustained increase in 25(OH)D serum levels in all participants, which may explain its significant benefit on lower extremity function, systolic blood pressure, and innate immune response compared with vitamin D3. © 2012 American Society for Bone and Mineral Research |
| doi_str_mv | 10.1002/jbmr.551 |
| format | Article |
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Twenty healthy postmenopausal women with an average 25(OH)D level of 13.2 ± 3.9 ng/mL (mean ± SD) and a mean age of 61.5 ± 7.2 years were randomized to either 20 µg of HyD or 20 µg (800 IU) of vitamin D3 per day in a double‐blind manner. We measured on 14 visits over 4 months, 25(OH)D serum levels, blood pressure, and seven markers of innate immunity (eotaxin, interleukin [IL]‐8, IL‐12, interferon gamma‐induced protein 10 kDa [IP‐10], monocyte chemotactic protein‐1 [MCP‐1], macrophage inflammatory protein beta [MIP‐1β], and “Regulated upon Activation, Normal T‐cell Expressed, and Secreted” [RANTES]). At baseline and at 4 months, a test battery for lower extremity function (knee extensor and flexor strength, timed up and go, repeated sit‐to‐stand) was assessed. All analyses were adjusted for baseline measurement, age, and body mass index. Mean 25(OH)D levels increased to 69.5 ng/mL in the HyD group. This rise was immediate and sustained. Mean 25(OH)D levels increased to 31.0 ng/mL with a slow increase in the vitamin D3 group. Women on HyD compared with vitamin D3 had a 2.8‐fold increased odds of maintained or improved lower extremity function (odds ratio [OR] = 2.79; 95% confidence interval [CI], 1.18–6.58), and a 5.7‐mmHg decrease in systolic blood pressure (p = 0.0002). Both types of vitamin D contributed to a decrease in five out of seven markers of innate immunity, significantly more pronounced with HyD for eotaxin, IL‐12, MCP‐1, and MIP‐1 β. There were no cases of hypercalcemia at any time point. Twenty micrograms (20 µg) of HyD per day resulted in a safe, immediate, and sustained increase in 25(OH)D serum levels in all participants, which may explain its significant benefit on lower extremity function, systolic blood pressure, and innate immune response compared with vitamin D3. © 2012 American Society for Bone and Mineral Research</description><identifier>ISSN: 0884-0431</identifier><identifier>EISSN: 1523-4681</identifier><identifier>DOI: 10.1002/jbmr.551</identifier><identifier>PMID: 22028071</identifier><identifier>CODEN: JBMREJ</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>25-HYDROXYVITAMIN D ; Administration, Oral ; Aged ; Biological and medical sciences ; Biomarkers - metabolism ; Blood Glucose - metabolism ; BLOOD PRESSURE ; Blood Pressure - drug effects ; Calcifediol - administration & dosage ; Calcifediol - pharmacology ; Calcium - blood ; Calcium - urine ; Cholecalciferol - administration & dosage ; Cholecalciferol - pharmacology ; Dietary Supplements ; Female ; FUNCTIONAL DECLINE ; Fundamental and applied biological sciences. Psychology ; Humans ; Immunity, Innate - drug effects ; Insulin - blood ; Lower Extremity - physiology ; MARKERS OF IMMUNITY ; Middle Aged ; Parathyroid Hormone - blood ; POSTMENOPAUSAL WOMEN ; Skeleton and joints ; Systole - drug effects ; Vertebrates: osteoarticular system, musculoskeletal system ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; VITAMIN D3</subject><ispartof>Journal of bone and mineral research, 2012-01, Vol.27 (1), p.160-169</ispartof><rights>Copyright © 2012 American Society for Bone and Mineral Research</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 American Society for Bone and Mineral Research.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4171-6c6dd0b45f9cebb8b683a014aca6f907fda7471ce0c51d80676394e5119a7ace3</citedby><cites>FETCH-LOGICAL-c4171-6c6dd0b45f9cebb8b683a014aca6f907fda7471ce0c51d80676394e5119a7ace3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbmr.551$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbmr.551$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25493743$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22028071$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bischoff-Ferrari, Heike Annette</creatorcontrib><creatorcontrib>Dawson-Hughes, Bess</creatorcontrib><creatorcontrib>Stöcklin, Elisabeth</creatorcontrib><creatorcontrib>Sidelnikov, Eduard</creatorcontrib><creatorcontrib>Willett, Walter Churchill</creatorcontrib><creatorcontrib>Edel, John Orav</creatorcontrib><creatorcontrib>Stähelin, Hannes Balthasar</creatorcontrib><creatorcontrib>Wolfram, Swen</creatorcontrib><creatorcontrib>Jetter, Alexander</creatorcontrib><creatorcontrib>Schwager, Joseph</creatorcontrib><creatorcontrib>Henschkowski, Jana</creatorcontrib><creatorcontrib>von Eckardstein, Arnold</creatorcontrib><creatorcontrib>Egli, Andreas</creatorcontrib><title>Oral supplementation with 25(OH)D3 versus vitamin D3: Effects on 25(OH)D levels, lower extremity function, blood pressure, and markers of innate immunity</title><title>Journal of bone and mineral research</title><addtitle>J Bone Miner Res</addtitle><description>To test the effect of 25(OH)D3 (HyD) compared to vitamin D3 on serum 25‐hydroxyvitamin D levels (25(OH)D), lower extremity function, blood pressure, and markers of innate immunity. Twenty healthy postmenopausal women with an average 25(OH)D level of 13.2 ± 3.9 ng/mL (mean ± SD) and a mean age of 61.5 ± 7.2 years were randomized to either 20 µg of HyD or 20 µg (800 IU) of vitamin D3 per day in a double‐blind manner. We measured on 14 visits over 4 months, 25(OH)D serum levels, blood pressure, and seven markers of innate immunity (eotaxin, interleukin [IL]‐8, IL‐12, interferon gamma‐induced protein 10 kDa [IP‐10], monocyte chemotactic protein‐1 [MCP‐1], macrophage inflammatory protein beta [MIP‐1β], and “Regulated upon Activation, Normal T‐cell Expressed, and Secreted” [RANTES]). At baseline and at 4 months, a test battery for lower extremity function (knee extensor and flexor strength, timed up and go, repeated sit‐to‐stand) was assessed. All analyses were adjusted for baseline measurement, age, and body mass index. Mean 25(OH)D levels increased to 69.5 ng/mL in the HyD group. This rise was immediate and sustained. Mean 25(OH)D levels increased to 31.0 ng/mL with a slow increase in the vitamin D3 group. Women on HyD compared with vitamin D3 had a 2.8‐fold increased odds of maintained or improved lower extremity function (odds ratio [OR] = 2.79; 95% confidence interval [CI], 1.18–6.58), and a 5.7‐mmHg decrease in systolic blood pressure (p = 0.0002). Both types of vitamin D contributed to a decrease in five out of seven markers of innate immunity, significantly more pronounced with HyD for eotaxin, IL‐12, MCP‐1, and MIP‐1 β. There were no cases of hypercalcemia at any time point. Twenty micrograms (20 µg) of HyD per day resulted in a safe, immediate, and sustained increase in 25(OH)D serum levels in all participants, which may explain its significant benefit on lower extremity function, systolic blood pressure, and innate immune response compared with vitamin D3. © 2012 American Society for Bone and Mineral Research</description><subject>25-HYDROXYVITAMIN D</subject><subject>Administration, Oral</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - metabolism</subject><subject>Blood Glucose - metabolism</subject><subject>BLOOD PRESSURE</subject><subject>Blood Pressure - drug effects</subject><subject>Calcifediol - administration & dosage</subject><subject>Calcifediol - pharmacology</subject><subject>Calcium - blood</subject><subject>Calcium - urine</subject><subject>Cholecalciferol - administration & dosage</subject><subject>Cholecalciferol - pharmacology</subject><subject>Dietary Supplements</subject><subject>Female</subject><subject>FUNCTIONAL DECLINE</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Immunity, Innate - drug effects</subject><subject>Insulin - blood</subject><subject>Lower Extremity - physiology</subject><subject>MARKERS OF IMMUNITY</subject><subject>Middle Aged</subject><subject>Parathyroid Hormone - blood</subject><subject>POSTMENOPAUSAL WOMEN</subject><subject>Skeleton and joints</subject><subject>Systole - drug effects</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>VITAMIN D3</subject><issn>0884-0431</issn><issn>1523-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10V1v0zAUBuAIgVgZSPwCZAkhbVIz7Pgr4Y59sDENKsFgl5bjnAgXxyl20q4_Zf8Wl5ZNQuLKN4_fc47eLHtJ8BHBuHg7r7twxDl5lE0IL2jOREkeZxNclizHjJK97FmMc4yx4EI8zfaKAhcllmSS3c2CdiiOi4WDDvygB9t7tLLDD1Twg9nF4SlFSwhxjGhpB91Zj07pO3TWtmCGiJLdMeRgCS5OketXEBDcDgE6O6xRO3qzCZ2i2vV9gxYBYhwDTJH2Dep0-JniUd8i670eANmuG336-Dx70moX4cXu3c--fTi7PrnIr2bnH0_eX-WGEUlyYUTT4JrxtjJQ12UtSqoxYdpo0VZYto2WTBID2HDSlFhIQSsGnJBKS22A7mcH29xF6H-NEAfV2WjAOe2hH6MiRVlgJimXib7-h877Mfi03R9FCJOVeAg0oY8xQKsWwaY714pgtalLbepSqa5EX-0Cx7qD5h7-7SeBNzugo9GuDdobGx8cZxWVjCaXb93KOlj_d6C6PP70ZTt4520c4PbepzKUkFRydfP5XH29OaaX1-V3VdDfE8e6kw</recordid><startdate>201201</startdate><enddate>201201</enddate><creator>Bischoff-Ferrari, Heike Annette</creator><creator>Dawson-Hughes, Bess</creator><creator>Stöcklin, Elisabeth</creator><creator>Sidelnikov, Eduard</creator><creator>Willett, Walter Churchill</creator><creator>Edel, John Orav</creator><creator>Stähelin, Hannes Balthasar</creator><creator>Wolfram, Swen</creator><creator>Jetter, Alexander</creator><creator>Schwager, Joseph</creator><creator>Henschkowski, Jana</creator><creator>von Eckardstein, Arnold</creator><creator>Egli, Andreas</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TS</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201201</creationdate><title>Oral supplementation with 25(OH)D3 versus vitamin D3: Effects on 25(OH)D levels, lower extremity function, blood pressure, and markers of innate immunity</title><author>Bischoff-Ferrari, Heike Annette ; Dawson-Hughes, Bess ; Stöcklin, Elisabeth ; Sidelnikov, Eduard ; Willett, Walter Churchill ; Edel, John Orav ; Stähelin, Hannes Balthasar ; Wolfram, Swen ; Jetter, Alexander ; Schwager, Joseph ; Henschkowski, Jana ; von Eckardstein, Arnold ; Egli, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4171-6c6dd0b45f9cebb8b683a014aca6f907fda7471ce0c51d80676394e5119a7ace3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>25-HYDROXYVITAMIN D</topic><topic>Administration, Oral</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - metabolism</topic><topic>Blood Glucose - metabolism</topic><topic>BLOOD PRESSURE</topic><topic>Blood Pressure - drug effects</topic><topic>Calcifediol - administration & dosage</topic><topic>Calcifediol - pharmacology</topic><topic>Calcium - blood</topic><topic>Calcium - urine</topic><topic>Cholecalciferol - administration & dosage</topic><topic>Cholecalciferol - pharmacology</topic><topic>Dietary Supplements</topic><topic>Female</topic><topic>FUNCTIONAL DECLINE</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Immunity, Innate - drug effects</topic><topic>Insulin - blood</topic><topic>Lower Extremity - physiology</topic><topic>MARKERS OF IMMUNITY</topic><topic>Middle Aged</topic><topic>Parathyroid Hormone - blood</topic><topic>POSTMENOPAUSAL WOMEN</topic><topic>Skeleton and joints</topic><topic>Systole - drug effects</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>VITAMIN D3</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bischoff-Ferrari, Heike Annette</creatorcontrib><creatorcontrib>Dawson-Hughes, Bess</creatorcontrib><creatorcontrib>Stöcklin, Elisabeth</creatorcontrib><creatorcontrib>Sidelnikov, Eduard</creatorcontrib><creatorcontrib>Willett, Walter Churchill</creatorcontrib><creatorcontrib>Edel, John Orav</creatorcontrib><creatorcontrib>Stähelin, Hannes Balthasar</creatorcontrib><creatorcontrib>Wolfram, Swen</creatorcontrib><creatorcontrib>Jetter, Alexander</creatorcontrib><creatorcontrib>Schwager, Joseph</creatorcontrib><creatorcontrib>Henschkowski, Jana</creatorcontrib><creatorcontrib>von Eckardstein, Arnold</creatorcontrib><creatorcontrib>Egli, Andreas</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of bone and mineral research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bischoff-Ferrari, Heike Annette</au><au>Dawson-Hughes, Bess</au><au>Stöcklin, Elisabeth</au><au>Sidelnikov, Eduard</au><au>Willett, Walter Churchill</au><au>Edel, John Orav</au><au>Stähelin, Hannes Balthasar</au><au>Wolfram, Swen</au><au>Jetter, Alexander</au><au>Schwager, Joseph</au><au>Henschkowski, Jana</au><au>von Eckardstein, Arnold</au><au>Egli, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral supplementation with 25(OH)D3 versus vitamin D3: Effects on 25(OH)D levels, lower extremity function, blood pressure, and markers of innate immunity</atitle><jtitle>Journal of bone and mineral research</jtitle><addtitle>J Bone Miner Res</addtitle><date>2012-01</date><risdate>2012</risdate><volume>27</volume><issue>1</issue><spage>160</spage><epage>169</epage><pages>160-169</pages><issn>0884-0431</issn><eissn>1523-4681</eissn><coden>JBMREJ</coden><abstract>To test the effect of 25(OH)D3 (HyD) compared to vitamin D3 on serum 25‐hydroxyvitamin D levels (25(OH)D), lower extremity function, blood pressure, and markers of innate immunity. Twenty healthy postmenopausal women with an average 25(OH)D level of 13.2 ± 3.9 ng/mL (mean ± SD) and a mean age of 61.5 ± 7.2 years were randomized to either 20 µg of HyD or 20 µg (800 IU) of vitamin D3 per day in a double‐blind manner. We measured on 14 visits over 4 months, 25(OH)D serum levels, blood pressure, and seven markers of innate immunity (eotaxin, interleukin [IL]‐8, IL‐12, interferon gamma‐induced protein 10 kDa [IP‐10], monocyte chemotactic protein‐1 [MCP‐1], macrophage inflammatory protein beta [MIP‐1β], and “Regulated upon Activation, Normal T‐cell Expressed, and Secreted” [RANTES]). At baseline and at 4 months, a test battery for lower extremity function (knee extensor and flexor strength, timed up and go, repeated sit‐to‐stand) was assessed. All analyses were adjusted for baseline measurement, age, and body mass index. Mean 25(OH)D levels increased to 69.5 ng/mL in the HyD group. This rise was immediate and sustained. Mean 25(OH)D levels increased to 31.0 ng/mL with a slow increase in the vitamin D3 group. Women on HyD compared with vitamin D3 had a 2.8‐fold increased odds of maintained or improved lower extremity function (odds ratio [OR] = 2.79; 95% confidence interval [CI], 1.18–6.58), and a 5.7‐mmHg decrease in systolic blood pressure (p = 0.0002). Both types of vitamin D contributed to a decrease in five out of seven markers of innate immunity, significantly more pronounced with HyD for eotaxin, IL‐12, MCP‐1, and MIP‐1 β. There were no cases of hypercalcemia at any time point. Twenty micrograms (20 µg) of HyD per day resulted in a safe, immediate, and sustained increase in 25(OH)D serum levels in all participants, which may explain its significant benefit on lower extremity function, systolic blood pressure, and innate immune response compared with vitamin D3. © 2012 American Society for Bone and Mineral Research</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22028071</pmid><doi>10.1002/jbmr.551</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of bone and mineral research, 2012-01, Vol.27 (1), p.160-169 |
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| source | MEDLINE; Access via Wiley Online Library; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | 25-HYDROXYVITAMIN D Administration, Oral Aged Biological and medical sciences Biomarkers - metabolism Blood Glucose - metabolism BLOOD PRESSURE Blood Pressure - drug effects Calcifediol - administration & dosage Calcifediol - pharmacology Calcium - blood Calcium - urine Cholecalciferol - administration & dosage Cholecalciferol - pharmacology Dietary Supplements Female FUNCTIONAL DECLINE Fundamental and applied biological sciences. Psychology Humans Immunity, Innate - drug effects Insulin - blood Lower Extremity - physiology MARKERS OF IMMUNITY Middle Aged Parathyroid Hormone - blood POSTMENOPAUSAL WOMEN Skeleton and joints Systole - drug effects Vertebrates: osteoarticular system, musculoskeletal system Vitamin D - analogs & derivatives Vitamin D - blood VITAMIN D3 |
| title | Oral supplementation with 25(OH)D3 versus vitamin D3: Effects on 25(OH)D levels, lower extremity function, blood pressure, and markers of innate immunity |
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