Transforming growth factor-β1 induces matrix metalloproteinase-9 expression in rat vascular smooth muscle cells via ROS-dependent ERK–NF-κB pathways

Both matrix metalloproteinase-9 (MMP9) and transforming growth factors-β1 (TGF-β1) are the important factors in the pathogenesis of the aortic aneurysm (AA) and aortic dissection (AD). Recent studies have shown that inhibition of reactive oxygen species (ROS) production, extracellular signal–regulat...

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Veröffentlicht in:	Molecular and cellular biochemistry 2013-03, Vol.375 (1-2), p.11-21
Hauptverfasser:	Zhang, Hao, Wang, Zhi-Wei, Wu, Hong-Bing, Li, Zhi, Li, Luo-Cheng, Hu, Xiao-Ping, Ren, Zong-Li, Li, Bai-Jun, Hu, Zhi-Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Aneurysms Animals Biochemistry Biomedical and Life Sciences Bone morphogenetic proteins Cardiology Cell Line Enzyme Induction Extracellular Signal-Regulated MAP Kinases - metabolism Genetic transcription Life Sciences MAP Kinase Signaling System Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Medical Biochemistry Muscle, Smooth, Vascular - cytology Myocytes, Smooth Muscle - enzymology Oncology Rats Reactive Oxygen Species - metabolism Smooth muscle Transcription Factor RelA - metabolism Transforming Growth Factor beta1 - physiology Transforming growth factors
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