Effects of spironolactone administration on the podocytes loss and progression of experimental diabetic nephropathy

Evaluate the effect of spironolactone (SPL) on the loss of podocytes during the progression of experimental diabetic nephropathy (DN). A group of male Holtzman rats randomly received streptozotocin (diabetic group) or a buffer citrate (control group). Diabetic rats were treated with SPL (50 mg/kg/da...

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Veröffentlicht in:	Revista peruana de medicina experimental y salud pública 2012-10, Vol.29 (4), p.490-497
Hauptverfasser:	Aguilar, Cristian, Rodríguez-Delfín, Luis
Format:	Artikel
Sprache:	eng ; spa
Schlagworte:	Animals Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - prevention & control Diabetic Nephropathies - pathology Diabetic Nephropathies - prevention & control Disease Progression Male Mineralocorticoid Receptor Antagonists - pharmacology Mineralocorticoid Receptor Antagonists - therapeutic use Podocytes - drug effects Rats Rats, Sprague-Dawley Spironolactone - pharmacology Spironolactone - therapeutic use
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