Frequency and risk factors of non-retinopathy ocular conditions in people with diabetes: the Singapore Malay Eye Study
Aim To investigate the frequency and risk factors of non‐retinopathy ocular conditions in persons with diabetes. Methods A population‐based cross‐sectional study of 3176 Malay persons aged between 40 and 79 years in Singapore was conducted. Cataract, glaucoma, refractive errors, age‐related macular...
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| Veröffentlicht in: | Diabetic medicine 2013-02, Vol.30 (2), p.e32-e40 |
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| creator | Chiang, P. P.-C. Lamoureux, E. L. Zheng, Y. Tay, W. T. Mitchell, P. Wang, J. J. Wong, T. Y. |
| description | Aim
To investigate the frequency and risk factors of non‐retinopathy ocular conditions in persons with diabetes.
Methods
A population‐based cross‐sectional study of 3176 Malay persons aged between 40 and 79 years in Singapore was conducted. Cataract, glaucoma, refractive errors, age‐related macular degeneration, dry eye, epiretinal membrane, ocular hypertension and retinal conditions were assessed based on standardized interviews, clinical examinations and laboratory investigations.
Results
A total of 768 participants (24.2%) had diabetes. People with diabetes were more likely to have cortical cataract (52.1 vs. 37.3%, P |
| doi_str_mv | 10.1111/dme.12053 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1273780812</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2870911911</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4263-2c11ce053e3bac5ced0500f35275df4401aeaa6205cb63f0e255b8f85d7c9f3d3</originalsourceid><addsrcrecordid>eNp1kU1v1DAQhi0EokvhwB9AlrjAIa0_4mTDrSrbgtTlQ3zs0XLsMes2awfboeTf47JtD0jMZaTRM6_mnReh55Qc0VLHZgdHlBHBH6AFrZu6EnVHH6IFaWtWcdLSA_QkpUtCKOt49xgdsDKsu44s0K-zCD8n8HrGyhscXbrCVukcYsLBYh98FSE7H0aVtzMOehpUxDp447ILPmHn8QhhHABfu7zFxqkeMqQ3OG8Bf3H-hxpDBLxWg5rxai6zPJn5KXpk1ZDg2W0_RN_OVl9P31UXH8_fn55cVLpmDa-YplRDMQa8V1poMEQQYrlgrTC2rglVoFRTrOu-4ZYAE6Jf2qUwre4sN_wQvdrrjjEUmynLnUsahkF5CFOSlLW8XZIlZQV9-Q96Gaboy3U3FG3bjtVdoV7vKR1DShGsHKPbqThLSuRNGLKEIf-GUdgXt4pTvwNzT959vwDHe-DaDTD_X0m-Xa_uJKv9hksZft9vqHglm-JEyM2Hc7n5vNnQT9_XkvI_uBWjOA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1271779249</pqid></control><display><type>article</type><title>Frequency and risk factors of non-retinopathy ocular conditions in people with diabetes: the Singapore Malay Eye Study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Chiang, P. P.-C. ; Lamoureux, E. L. ; Zheng, Y. ; Tay, W. T. ; Mitchell, P. ; Wang, J. J. ; Wong, T. Y.</creator><creatorcontrib>Chiang, P. P.-C. ; Lamoureux, E. L. ; Zheng, Y. ; Tay, W. T. ; Mitchell, P. ; Wang, J. J. ; Wong, T. Y.</creatorcontrib><description>Aim
To investigate the frequency and risk factors of non‐retinopathy ocular conditions in persons with diabetes.
Methods
A population‐based cross‐sectional study of 3176 Malay persons aged between 40 and 79 years in Singapore was conducted. Cataract, glaucoma, refractive errors, age‐related macular degeneration, dry eye, epiretinal membrane, ocular hypertension and retinal conditions were assessed based on standardized interviews, clinical examinations and laboratory investigations.
Results
A total of 768 participants (24.2%) had diabetes. People with diabetes were more likely to have cortical cataract (52.1 vs. 37.3%, P < 0.001), ocular hypertension (10.9 vs. 7.4%, P = 0.002) and epiretinal membrane (17.2 vs. 10.1%, P < 0.001) compared with those without diabetes. The odds of having cortical cataract (odds ratio 1.63, 95% CI 1.20–2.20) and epiretinal membrane (among those with previous cataract surgery: odds ratio 1.63, 95% CI 1.20–2.20) were significantly higher in people with diabetes compared with those without. The population attributable risks for cortical cataract and epiretinal membrane because of diabetes were 8.7 and 9.0%, respectively. In persons with diabetes, hypertension and high cholesterol were the major risk factors associated with non‐retinopathy eye complications such as ocular hypertension (odds ratio 1.18, 95% CI 1.04–1.33) and retinal emboli (odds ratio 1.99, 95% CI 1.05–3.80).
Conclusion
Our results allow clinicians to better inform patients with diabetes that they are more likely to have cortical cataract and epiretinal membranes (those with previous cataract surgery) in addition to diabetic retinopathy. Two modifiable risk factors—blood pressure and cholesterol associated with ocular hypertension and retinal emboli, respectively—are also risk factors for non‐retinopathy ocular conditions in persons with diabetes.</description><identifier>ISSN: 0742-3071</identifier><identifier>EISSN: 1464-5491</identifier><identifier>DOI: 10.1111/dme.12053</identifier><identifier>PMID: 23074990</identifier><identifier>CODEN: DIMEEV</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Blood Glucose - metabolism ; Body Mass Index ; Cataract - blood ; Cataract - epidemiology ; Cross-Sectional Studies ; Diabetes ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - epidemiology ; Dry Eye Syndromes - blood ; Dry Eye Syndromes - epidemiology ; Female ; Glaucoma - blood ; Glaucoma - epidemiology ; Humans ; Macular Degeneration - blood ; Macular Degeneration - epidemiology ; Male ; Middle Aged ; Prevalence ; Retinal Diseases - blood ; Retinal Diseases - epidemiology ; Risk Factors ; Singapore - epidemiology ; Surveys and Questionnaires</subject><ispartof>Diabetic medicine, 2013-02, Vol.30 (2), p.e32-e40</ispartof><rights>2012 The Authors. Diabetic Medicine © 2012 Diabetes UK</rights><rights>2012 The Authors. Diabetic Medicine © 2012 Diabetes UK.</rights><rights>Diabetic Medicine © 2013 Diabetes UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4263-2c11ce053e3bac5ced0500f35275df4401aeaa6205cb63f0e255b8f85d7c9f3d3</citedby><cites>FETCH-LOGICAL-c4263-2c11ce053e3bac5ced0500f35275df4401aeaa6205cb63f0e255b8f85d7c9f3d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fdme.12053$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fdme.12053$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23074990$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chiang, P. P.-C.</creatorcontrib><creatorcontrib>Lamoureux, E. L.</creatorcontrib><creatorcontrib>Zheng, Y.</creatorcontrib><creatorcontrib>Tay, W. T.</creatorcontrib><creatorcontrib>Mitchell, P.</creatorcontrib><creatorcontrib>Wang, J. J.</creatorcontrib><creatorcontrib>Wong, T. Y.</creatorcontrib><title>Frequency and risk factors of non-retinopathy ocular conditions in people with diabetes: the Singapore Malay Eye Study</title><title>Diabetic medicine</title><addtitle>Diabet. Med</addtitle><description>Aim
To investigate the frequency and risk factors of non‐retinopathy ocular conditions in persons with diabetes.
Methods
A population‐based cross‐sectional study of 3176 Malay persons aged between 40 and 79 years in Singapore was conducted. Cataract, glaucoma, refractive errors, age‐related macular degeneration, dry eye, epiretinal membrane, ocular hypertension and retinal conditions were assessed based on standardized interviews, clinical examinations and laboratory investigations.
Results
A total of 768 participants (24.2%) had diabetes. People with diabetes were more likely to have cortical cataract (52.1 vs. 37.3%, P < 0.001), ocular hypertension (10.9 vs. 7.4%, P = 0.002) and epiretinal membrane (17.2 vs. 10.1%, P < 0.001) compared with those without diabetes. The odds of having cortical cataract (odds ratio 1.63, 95% CI 1.20–2.20) and epiretinal membrane (among those with previous cataract surgery: odds ratio 1.63, 95% CI 1.20–2.20) were significantly higher in people with diabetes compared with those without. The population attributable risks for cortical cataract and epiretinal membrane because of diabetes were 8.7 and 9.0%, respectively. In persons with diabetes, hypertension and high cholesterol were the major risk factors associated with non‐retinopathy eye complications such as ocular hypertension (odds ratio 1.18, 95% CI 1.04–1.33) and retinal emboli (odds ratio 1.99, 95% CI 1.05–3.80).
Conclusion
Our results allow clinicians to better inform patients with diabetes that they are more likely to have cortical cataract and epiretinal membranes (those with previous cataract surgery) in addition to diabetic retinopathy. Two modifiable risk factors—blood pressure and cholesterol associated with ocular hypertension and retinal emboli, respectively—are also risk factors for non‐retinopathy ocular conditions in persons with diabetes.</description><subject>Adult</subject><subject>Aged</subject><subject>Blood Glucose - metabolism</subject><subject>Body Mass Index</subject><subject>Cataract - blood</subject><subject>Cataract - epidemiology</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Dry Eye Syndromes - blood</subject><subject>Dry Eye Syndromes - epidemiology</subject><subject>Female</subject><subject>Glaucoma - blood</subject><subject>Glaucoma - epidemiology</subject><subject>Humans</subject><subject>Macular Degeneration - blood</subject><subject>Macular Degeneration - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Retinal Diseases - blood</subject><subject>Retinal Diseases - epidemiology</subject><subject>Risk Factors</subject><subject>Singapore - epidemiology</subject><subject>Surveys and Questionnaires</subject><issn>0742-3071</issn><issn>1464-5491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v1DAQhi0EokvhwB9AlrjAIa0_4mTDrSrbgtTlQ3zs0XLsMes2awfboeTf47JtD0jMZaTRM6_mnReh55Qc0VLHZgdHlBHBH6AFrZu6EnVHH6IFaWtWcdLSA_QkpUtCKOt49xgdsDKsu44s0K-zCD8n8HrGyhscXbrCVukcYsLBYh98FSE7H0aVtzMOehpUxDp447ILPmHn8QhhHABfu7zFxqkeMqQ3OG8Bf3H-hxpDBLxWg5rxai6zPJn5KXpk1ZDg2W0_RN_OVl9P31UXH8_fn55cVLpmDa-YplRDMQa8V1poMEQQYrlgrTC2rglVoFRTrOu-4ZYAE6Jf2qUwre4sN_wQvdrrjjEUmynLnUsahkF5CFOSlLW8XZIlZQV9-Q96Gaboy3U3FG3bjtVdoV7vKR1DShGsHKPbqThLSuRNGLKEIf-GUdgXt4pTvwNzT959vwDHe-DaDTD_X0m-Xa_uJKv9hksZft9vqHglm-JEyM2Hc7n5vNnQT9_XkvI_uBWjOA</recordid><startdate>201302</startdate><enddate>201302</enddate><creator>Chiang, P. P.-C.</creator><creator>Lamoureux, E. L.</creator><creator>Zheng, Y.</creator><creator>Tay, W. T.</creator><creator>Mitchell, P.</creator><creator>Wang, J. J.</creator><creator>Wong, T. Y.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201302</creationdate><title>Frequency and risk factors of non-retinopathy ocular conditions in people with diabetes: the Singapore Malay Eye Study</title><author>Chiang, P. P.-C. ; Lamoureux, E. L. ; Zheng, Y. ; Tay, W. T. ; Mitchell, P. ; Wang, J. J. ; Wong, T. Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4263-2c11ce053e3bac5ced0500f35275df4401aeaa6205cb63f0e255b8f85d7c9f3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Blood Glucose - metabolism</topic><topic>Body Mass Index</topic><topic>Cataract - blood</topic><topic>Cataract - epidemiology</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Dry Eye Syndromes - blood</topic><topic>Dry Eye Syndromes - epidemiology</topic><topic>Female</topic><topic>Glaucoma - blood</topic><topic>Glaucoma - epidemiology</topic><topic>Humans</topic><topic>Macular Degeneration - blood</topic><topic>Macular Degeneration - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Retinal Diseases - blood</topic><topic>Retinal Diseases - epidemiology</topic><topic>Risk Factors</topic><topic>Singapore - epidemiology</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chiang, P. P.-C.</creatorcontrib><creatorcontrib>Lamoureux, E. L.</creatorcontrib><creatorcontrib>Zheng, Y.</creatorcontrib><creatorcontrib>Tay, W. T.</creatorcontrib><creatorcontrib>Mitchell, P.</creatorcontrib><creatorcontrib>Wang, J. J.</creatorcontrib><creatorcontrib>Wong, T. Y.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chiang, P. P.-C.</au><au>Lamoureux, E. L.</au><au>Zheng, Y.</au><au>Tay, W. T.</au><au>Mitchell, P.</au><au>Wang, J. J.</au><au>Wong, T. Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frequency and risk factors of non-retinopathy ocular conditions in people with diabetes: the Singapore Malay Eye Study</atitle><jtitle>Diabetic medicine</jtitle><addtitle>Diabet. Med</addtitle><date>2013-02</date><risdate>2013</risdate><volume>30</volume><issue>2</issue><spage>e32</spage><epage>e40</epage><pages>e32-e40</pages><issn>0742-3071</issn><eissn>1464-5491</eissn><coden>DIMEEV</coden><abstract>Aim
To investigate the frequency and risk factors of non‐retinopathy ocular conditions in persons with diabetes.
Methods
A population‐based cross‐sectional study of 3176 Malay persons aged between 40 and 79 years in Singapore was conducted. Cataract, glaucoma, refractive errors, age‐related macular degeneration, dry eye, epiretinal membrane, ocular hypertension and retinal conditions were assessed based on standardized interviews, clinical examinations and laboratory investigations.
Results
A total of 768 participants (24.2%) had diabetes. People with diabetes were more likely to have cortical cataract (52.1 vs. 37.3%, P < 0.001), ocular hypertension (10.9 vs. 7.4%, P = 0.002) and epiretinal membrane (17.2 vs. 10.1%, P < 0.001) compared with those without diabetes. The odds of having cortical cataract (odds ratio 1.63, 95% CI 1.20–2.20) and epiretinal membrane (among those with previous cataract surgery: odds ratio 1.63, 95% CI 1.20–2.20) were significantly higher in people with diabetes compared with those without. The population attributable risks for cortical cataract and epiretinal membrane because of diabetes were 8.7 and 9.0%, respectively. In persons with diabetes, hypertension and high cholesterol were the major risk factors associated with non‐retinopathy eye complications such as ocular hypertension (odds ratio 1.18, 95% CI 1.04–1.33) and retinal emboli (odds ratio 1.99, 95% CI 1.05–3.80).
Conclusion
Our results allow clinicians to better inform patients with diabetes that they are more likely to have cortical cataract and epiretinal membranes (those with previous cataract surgery) in addition to diabetic retinopathy. Two modifiable risk factors—blood pressure and cholesterol associated with ocular hypertension and retinal emboli, respectively—are also risk factors for non‐retinopathy ocular conditions in persons with diabetes.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>23074990</pmid><doi>10.1111/dme.12053</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Blood Glucose - metabolism Body Mass Index Cataract - blood Cataract - epidemiology Cross-Sectional Studies Diabetes Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - epidemiology Dry Eye Syndromes - blood Dry Eye Syndromes - epidemiology Female Glaucoma - blood Glaucoma - epidemiology Humans Macular Degeneration - blood Macular Degeneration - epidemiology Male Middle Aged Prevalence Retinal Diseases - blood Retinal Diseases - epidemiology Risk Factors Singapore - epidemiology Surveys and Questionnaires |
| title | Frequency and risk factors of non-retinopathy ocular conditions in people with diabetes: the Singapore Malay Eye Study |
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