CYP2C1917 Gain-of-Function Polymorphism Is Associated With Peptic Ulcer Disease

Single‐nucleotide polymorphisms (SNPs) in the CYP2C gene cluster have been extensively investigated as predisposing factors for nonsteroidal anti‐inflammatory drug (NSAID)‐induced peptic ulcer disease (PUD) or upper gastrointestinal bleeding (UGIB). However, results have been inconclusive owing to d...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2013-02, Vol.93 (2), p.195-203
Hauptverfasser:	Musumba, C O, Jorgensen, A, Sutton, L, Van Eker, D, Zhang, E, O'Hara, N, Carr, D F, Pritchard, D M, Pirmohamed, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - adverse effects Aryl Hydrocarbon Hydroxylases - genetics Biological and medical sciences Case-Control Studies Cytochrome P-450 CYP2C19 European Continental Ancestry Group Female Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal Hemorrhage - chemically induced Gastrointestinal Hemorrhage - genetics Helicobacter Infections - complications Humans Logistic Models Male Medical sciences Odds Ratio Other diseases. Semiology Peptic Ulcer - chemically induced Peptic Ulcer - genetics Pharmacology. Drug treatments Polymorphism, Single Nucleotide Stomach. Duodenum. Small intestine. Colon. Rectum. Anus United Kingdom
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