Differential effects of activity dependent treatments on axonal regeneration and neuropathic pain after peripheral nerve injury
Activity treatments are useful strategies to increase axonal regeneration and functional recovery after nerve lesions. They are thought to benefit neuropathy by enhancing neurotrophic factor expression. Nevertheless the effects on sensory function are still unclear. Since neurotrophic factors also p...
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| Veröffentlicht in: | Experimental neurology 2013-02, Vol.240, p.157-167 |
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| creator | Cobianchi, Stefano Casals-Diaz, Laura Jaramillo, Jessica Navarro, Xavier |
| description | Activity treatments are useful strategies to increase axonal regeneration and functional recovery after nerve lesions. They are thought to benefit neuropathy by enhancing neurotrophic factor expression. Nevertheless the effects on sensory function are still unclear. Since neurotrophic factors also play a fundamental role in peripheral and central sensitization, we studied the effects of acute electrical stimulation and early treadmill exercise on nerve regeneration and on neuropathic pain, and the relation with the expression of neurotrophins. After sciatic nerve section and suture repair, rats were subjected to electrical stimulation (ES) for 4h after injury, forced treadmill running (TR) for 5days, or both treatments combined. Sciatic nerve section induced hyperalgesia in the medial area of the plantar skin in the injured paw. TR and ES differently but positively reduced adjacent neuropathic pain before and after sciatic reinnervation. ES enhanced motor and sensory reinnervation, and combination with TR induced strong agonistic effects in relieving pain. The differential effects of these activity treatments were related to changes in neurotrophic factor mRNA levels in sensory and motor neurons. ES speeded up expression of BDNF and GDNF in DRG, and of BDNF and NT3 in the ventral horn. TR reduced the levels of pro-nociceptive factors such as BDNF, NGF and GDNF in DRG. Combination of ES and TR induced intermediate levels suggesting an optimal balancing of treatment effects.
► Activity-dependent therapies are useful to improve or recover lost functions after nerve lesions. ► Early electrical stimulation enhances nerve regeneration, motor and sensory reinnervation. ► Forced treadmill exercise reduced adjacent neuropathic pain before and after sciatic reinnervation. ► Combination of electrical stimulation with treadmill exercise induced agonistic effects in relieving neuropathic pain. ► Effects of activity treatments were related to changes in neurotrophic factor expression in sensory and motor neurons. |
| doi_str_mv | 10.1016/j.expneurol.2012.11.023 |
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► Activity-dependent therapies are useful to improve or recover lost functions after nerve lesions. ► Early electrical stimulation enhances nerve regeneration, motor and sensory reinnervation. ► Forced treadmill exercise reduced adjacent neuropathic pain before and after sciatic reinnervation. ► Combination of electrical stimulation with treadmill exercise induced agonistic effects in relieving neuropathic pain. ► Effects of activity treatments were related to changes in neurotrophic factor expression in sensory and motor neurons.</description><identifier>ISSN: 0014-4886</identifier><identifier>EISSN: 1090-2430</identifier><identifier>DOI: 10.1016/j.expneurol.2012.11.023</identifier><identifier>PMID: 23201096</identifier><identifier>CODEN: EXNEAC</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Axons - physiology ; Biological and medical sciences ; Electric Stimulation Therapy - methods ; Electrical stimulation ; Exercise Therapy - methods ; Female ; Injuries of the nervous system and the skull. Diseases due to physical agents ; Medical sciences ; Nerve regeneration ; Nerve Regeneration - physiology ; Neuralgia - physiopathology ; Neuralgia - therapy ; Neurology ; Neuropathic pain ; Neurotrophins ; Peripheral Nerve Injuries - physiopathology ; Peripheral Nerve Injuries - therapy ; Physical Conditioning, Animal - physiology ; Rats ; Rats, Sprague-Dawley ; Recovery of Function - physiology ; Traumas. Diseases due to physical agents ; Treadmill training</subject><ispartof>Experimental neurology, 2013-02, Vol.240, p.157-167</ispartof><rights>2012 Elsevier Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-b72f00c3d6ad0c387b3862336a7a5ade786bb7a8d532f656e1c521bd7c877ab03</citedby><cites>FETCH-LOGICAL-c467t-b72f00c3d6ad0c387b3862336a7a5ade786bb7a8d532f656e1c521bd7c877ab03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.expneurol.2012.11.023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26898268$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23201096$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cobianchi, Stefano</creatorcontrib><creatorcontrib>Casals-Diaz, Laura</creatorcontrib><creatorcontrib>Jaramillo, Jessica</creatorcontrib><creatorcontrib>Navarro, Xavier</creatorcontrib><title>Differential effects of activity dependent treatments on axonal regeneration and neuropathic pain after peripheral nerve injury</title><title>Experimental neurology</title><addtitle>Exp Neurol</addtitle><description>Activity treatments are useful strategies to increase axonal regeneration and functional recovery after nerve lesions. They are thought to benefit neuropathy by enhancing neurotrophic factor expression. Nevertheless the effects on sensory function are still unclear. Since neurotrophic factors also play a fundamental role in peripheral and central sensitization, we studied the effects of acute electrical stimulation and early treadmill exercise on nerve regeneration and on neuropathic pain, and the relation with the expression of neurotrophins. After sciatic nerve section and suture repair, rats were subjected to electrical stimulation (ES) for 4h after injury, forced treadmill running (TR) for 5days, or both treatments combined. Sciatic nerve section induced hyperalgesia in the medial area of the plantar skin in the injured paw. TR and ES differently but positively reduced adjacent neuropathic pain before and after sciatic reinnervation. ES enhanced motor and sensory reinnervation, and combination with TR induced strong agonistic effects in relieving pain. The differential effects of these activity treatments were related to changes in neurotrophic factor mRNA levels in sensory and motor neurons. ES speeded up expression of BDNF and GDNF in DRG, and of BDNF and NT3 in the ventral horn. TR reduced the levels of pro-nociceptive factors such as BDNF, NGF and GDNF in DRG. Combination of ES and TR induced intermediate levels suggesting an optimal balancing of treatment effects.
► Activity-dependent therapies are useful to improve or recover lost functions after nerve lesions. ► Early electrical stimulation enhances nerve regeneration, motor and sensory reinnervation. ► Forced treadmill exercise reduced adjacent neuropathic pain before and after sciatic reinnervation. ► Combination of electrical stimulation with treadmill exercise induced agonistic effects in relieving neuropathic pain. ► Effects of activity treatments were related to changes in neurotrophic factor expression in sensory and motor neurons.</description><subject>Animals</subject><subject>Axons - physiology</subject><subject>Biological and medical sciences</subject><subject>Electric Stimulation Therapy - methods</subject><subject>Electrical stimulation</subject><subject>Exercise Therapy - methods</subject><subject>Female</subject><subject>Injuries of the nervous system and the skull. Diseases due to physical agents</subject><subject>Medical sciences</subject><subject>Nerve regeneration</subject><subject>Nerve Regeneration - physiology</subject><subject>Neuralgia - physiopathology</subject><subject>Neuralgia - therapy</subject><subject>Neurology</subject><subject>Neuropathic pain</subject><subject>Neurotrophins</subject><subject>Peripheral Nerve Injuries - physiopathology</subject><subject>Peripheral Nerve Injuries - therapy</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Recovery of Function - physiology</subject><subject>Traumas. Diseases due to physical agents</subject><subject>Treadmill training</subject><issn>0014-4886</issn><issn>1090-2430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi1ERbeFvwC-IPWS4I-snRyrthSkSlzK2ZrYE-pV1gm2s-qe-Ot42aUcuXhGo-e1R48J-cBZzRlXnzY1Ps8BlziNtWBc1JzXTMhXZMVZxyrRSPaarBjjTdW0rTonFyltGGNdI_Qbci5kCbFOrcivWz8MGDFkDyPF0tuc6DRQsNnvfN5ThzMGVwCaI0Lelq4AgcLzFEok4g8MGCH7wyw4-merGfKTt3QGX4ZDxkhnjH5-KuBYiLhD6sNmifu35GyAMeG7U70k3z_fPd58qR6-3X-9uX6obKN0rnotBsasdApcKa3uZauElAo0rMGhblXfa2jdWopBrRVyuxa8d9q2WkPP5CW5Ot47x-nngimbrU8WxxECTksyXGiptVbdAdVH1MYppYiDmaPfQtwbzszBvtmYF_vmYN9wbor9knx_emTpt-hecn91F-DjCYBkYRwiBOvTP061XVuOwl0fOSxKdh6jSdZjsOh8LB9k3OT_u8xv7FarCQ</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Cobianchi, Stefano</creator><creator>Casals-Diaz, Laura</creator><creator>Jaramillo, Jessica</creator><creator>Navarro, Xavier</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130201</creationdate><title>Differential effects of activity dependent treatments on axonal regeneration and neuropathic pain after peripheral nerve injury</title><author>Cobianchi, Stefano ; Casals-Diaz, Laura ; Jaramillo, Jessica ; Navarro, Xavier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-b72f00c3d6ad0c387b3862336a7a5ade786bb7a8d532f656e1c521bd7c877ab03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Axons - physiology</topic><topic>Biological and medical sciences</topic><topic>Electric Stimulation Therapy - methods</topic><topic>Electrical stimulation</topic><topic>Exercise Therapy - methods</topic><topic>Female</topic><topic>Injuries of the nervous system and the skull. Diseases due to physical agents</topic><topic>Medical sciences</topic><topic>Nerve regeneration</topic><topic>Nerve Regeneration - physiology</topic><topic>Neuralgia - physiopathology</topic><topic>Neuralgia - therapy</topic><topic>Neurology</topic><topic>Neuropathic pain</topic><topic>Neurotrophins</topic><topic>Peripheral Nerve Injuries - physiopathology</topic><topic>Peripheral Nerve Injuries - therapy</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Recovery of Function - physiology</topic><topic>Traumas. Diseases due to physical agents</topic><topic>Treadmill training</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cobianchi, Stefano</creatorcontrib><creatorcontrib>Casals-Diaz, Laura</creatorcontrib><creatorcontrib>Jaramillo, Jessica</creatorcontrib><creatorcontrib>Navarro, Xavier</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cobianchi, Stefano</au><au>Casals-Diaz, Laura</au><au>Jaramillo, Jessica</au><au>Navarro, Xavier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential effects of activity dependent treatments on axonal regeneration and neuropathic pain after peripheral nerve injury</atitle><jtitle>Experimental neurology</jtitle><addtitle>Exp Neurol</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>240</volume><spage>157</spage><epage>167</epage><pages>157-167</pages><issn>0014-4886</issn><eissn>1090-2430</eissn><coden>EXNEAC</coden><abstract>Activity treatments are useful strategies to increase axonal regeneration and functional recovery after nerve lesions. They are thought to benefit neuropathy by enhancing neurotrophic factor expression. Nevertheless the effects on sensory function are still unclear. Since neurotrophic factors also play a fundamental role in peripheral and central sensitization, we studied the effects of acute electrical stimulation and early treadmill exercise on nerve regeneration and on neuropathic pain, and the relation with the expression of neurotrophins. After sciatic nerve section and suture repair, rats were subjected to electrical stimulation (ES) for 4h after injury, forced treadmill running (TR) for 5days, or both treatments combined. Sciatic nerve section induced hyperalgesia in the medial area of the plantar skin in the injured paw. TR and ES differently but positively reduced adjacent neuropathic pain before and after sciatic reinnervation. ES enhanced motor and sensory reinnervation, and combination with TR induced strong agonistic effects in relieving pain. The differential effects of these activity treatments were related to changes in neurotrophic factor mRNA levels in sensory and motor neurons. ES speeded up expression of BDNF and GDNF in DRG, and of BDNF and NT3 in the ventral horn. TR reduced the levels of pro-nociceptive factors such as BDNF, NGF and GDNF in DRG. Combination of ES and TR induced intermediate levels suggesting an optimal balancing of treatment effects.
► Activity-dependent therapies are useful to improve or recover lost functions after nerve lesions. ► Early electrical stimulation enhances nerve regeneration, motor and sensory reinnervation. ► Forced treadmill exercise reduced adjacent neuropathic pain before and after sciatic reinnervation. ► Combination of electrical stimulation with treadmill exercise induced agonistic effects in relieving neuropathic pain. ► Effects of activity treatments were related to changes in neurotrophic factor expression in sensory and motor neurons.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>23201096</pmid><doi>10.1016/j.expneurol.2012.11.023</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Axons - physiology Biological and medical sciences Electric Stimulation Therapy - methods Electrical stimulation Exercise Therapy - methods Female Injuries of the nervous system and the skull. Diseases due to physical agents Medical sciences Nerve regeneration Nerve Regeneration - physiology Neuralgia - physiopathology Neuralgia - therapy Neurology Neuropathic pain Neurotrophins Peripheral Nerve Injuries - physiopathology Peripheral Nerve Injuries - therapy Physical Conditioning, Animal - physiology Rats Rats, Sprague-Dawley Recovery of Function - physiology Traumas. Diseases due to physical agents Treadmill training |
| title | Differential effects of activity dependent treatments on axonal regeneration and neuropathic pain after peripheral nerve injury |
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