CXCR7 impact on CXCL12 biology and disease
It is known that the chemokine receptor CXCR7 (RDC1) can be engaged by both chemokines CXCL12 (SDF-1) and CXCL11 (I-TAC), but the exact expression pattern and function of CXCR7 is controversial. CXCR7 expression seems to be enhanced during pathological inflammation and tumor development, and emergin...
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| Veröffentlicht in: | Trends in molecular medicine 2013-01, Vol.19 (1), p.12-22 |
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| creator | Sánchez-Martín, Lorena Sánchez-Mateos, Paloma Cabañas, Carlos |
| description | It is known that the chemokine receptor CXCR7 (RDC1) can be engaged by both chemokines CXCL12 (SDF-1) and CXCL11 (I-TAC), but the exact expression pattern and function of CXCR7 is controversial. CXCR7 expression seems to be enhanced during pathological inflammation and tumor development, and emerging data suggest this receptor is an attractive therapeutic target for autoimmune diseases and cancer. CXCR7/CXCR4 heterodimerization, β-arrestin-mediated signaling, and modulation of CXCL12 responsiveness by CXCR7 suggest that the monogamous CXCR4/CXCL12 signaling axis is an oversimplified model that needs to be revisited. Consequently, research into CXCR7 biology is of great interest and further studies are warranted. This review summarizes recent findings about the CXCR7 receptor and analyses its impact on understanding the roles of CXCL12 biology in health and disease. |
| doi_str_mv | 10.1016/j.molmed.2012.10.004 |
| format | Article |
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CXCR7 expression seems to be enhanced during pathological inflammation and tumor development, and emerging data suggest this receptor is an attractive therapeutic target for autoimmune diseases and cancer. CXCR7/CXCR4 heterodimerization, β-arrestin-mediated signaling, and modulation of CXCL12 responsiveness by CXCR7 suggest that the monogamous CXCR4/CXCL12 signaling axis is an oversimplified model that needs to be revisited. Consequently, research into CXCR7 biology is of great interest and further studies are warranted. 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CXCR7 expression seems to be enhanced during pathological inflammation and tumor development, and emerging data suggest this receptor is an attractive therapeutic target for autoimmune diseases and cancer. CXCR7/CXCR4 heterodimerization, β-arrestin-mediated signaling, and modulation of CXCL12 responsiveness by CXCR7 suggest that the monogamous CXCR4/CXCL12 signaling axis is an oversimplified model that needs to be revisited. Consequently, research into CXCR7 biology is of great interest and further studies are warranted. This review summarizes recent findings about the CXCR7 receptor and analyses its impact on understanding the roles of CXCL12 biology in health and disease.</description><subject>Autoimmune Diseases - immunology</subject><subject>Autoimmune Diseases - metabolism</subject><subject>Chemokine CXCL11 - metabolism</subject><subject>Chemokine CXCL12 - physiology</subject><subject>chemokines</subject><subject>CXCL12</subject><subject>CXCR7</subject><subject>G-protein-coupled receptors (GPCRs)</subject><subject>Humans</subject><subject>Ligands</subject><subject>Neoplasms - immunology</subject><subject>Neoplasms - metabolism</subject><subject>Pathology</subject><subject>RDC1</subject><subject>Receptors, CXCR - chemistry</subject><subject>Receptors, CXCR - genetics</subject><subject>Receptors, CXCR - metabolism</subject><subject>seven-transmembrane spanning receptors (7-TMRs)</subject><subject>Signal Transduction</subject><issn>1471-4914</issn><issn>1471-499X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1LAzEQhoMotlb_gcgeRWjNJNlm9yJI8QsKgvbQW8gms5J1d1M3rdB_b5a2Hrx4ymTmnRnmeQm5BDoBCtPbatL4ukE7YRRYTE0oFUdkCELCWOT58vg3BjEgZyFUlEIqZXZKBoxDylOZDsnNbDl7k4lrVtqsE98m8T8HlhTO1_5jm-jWJtYF1AHPyUmp64AX-3dEFo8Pi9nzeP769DK7n4-NALkec8tBZJjlXOOU51xKlnNuirQsRTa1BVgogHIrpcTMCsBCUBSacWGpFMBH5Ho3dtX5rw2GtWpcMFjXukW_CQqY5DJlqaBRKnZS0_kQOizVqnON7rYKqOohqUrtIKkeUp-NkGLb1X7Dpuhrh6YDlSi42wkwnvntsFPBOGwNWtehWSvr3X8b_g4wtWud0fUnbjFUftO1EaECFZii6r03qvcJWPQozxn_AXkTiuY</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Sánchez-Martín, Lorena</creator><creator>Sánchez-Mateos, Paloma</creator><creator>Cabañas, Carlos</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130101</creationdate><title>CXCR7 impact on CXCL12 biology and disease</title><author>Sánchez-Martín, Lorena ; Sánchez-Mateos, Paloma ; Cabañas, Carlos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-3d3148e893ae6393772933cb5ff486db1d1b103d777e8d41eb40e4a234d07413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Autoimmune Diseases - immunology</topic><topic>Autoimmune Diseases - metabolism</topic><topic>Chemokine CXCL11 - metabolism</topic><topic>Chemokine CXCL12 - physiology</topic><topic>chemokines</topic><topic>CXCL12</topic><topic>CXCR7</topic><topic>G-protein-coupled receptors (GPCRs)</topic><topic>Humans</topic><topic>Ligands</topic><topic>Neoplasms - immunology</topic><topic>Neoplasms - metabolism</topic><topic>Pathology</topic><topic>RDC1</topic><topic>Receptors, CXCR - chemistry</topic><topic>Receptors, CXCR - genetics</topic><topic>Receptors, CXCR - metabolism</topic><topic>seven-transmembrane spanning receptors (7-TMRs)</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sánchez-Martín, Lorena</creatorcontrib><creatorcontrib>Sánchez-Mateos, Paloma</creatorcontrib><creatorcontrib>Cabañas, Carlos</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sánchez-Martín, Lorena</au><au>Sánchez-Mateos, Paloma</au><au>Cabañas, Carlos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CXCR7 impact on CXCL12 biology and disease</atitle><jtitle>Trends in molecular medicine</jtitle><addtitle>Trends Mol Med</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>19</volume><issue>1</issue><spage>12</spage><epage>22</epage><pages>12-22</pages><issn>1471-4914</issn><eissn>1471-499X</eissn><abstract>It is known that the chemokine receptor CXCR7 (RDC1) can be engaged by both chemokines CXCL12 (SDF-1) and CXCL11 (I-TAC), but the exact expression pattern and function of CXCR7 is controversial. CXCR7 expression seems to be enhanced during pathological inflammation and tumor development, and emerging data suggest this receptor is an attractive therapeutic target for autoimmune diseases and cancer. CXCR7/CXCR4 heterodimerization, β-arrestin-mediated signaling, and modulation of CXCL12 responsiveness by CXCR7 suggest that the monogamous CXCR4/CXCL12 signaling axis is an oversimplified model that needs to be revisited. Consequently, research into CXCR7 biology is of great interest and further studies are warranted. This review summarizes recent findings about the CXCR7 receptor and analyses its impact on understanding the roles of CXCL12 biology in health and disease.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>23153575</pmid><doi>10.1016/j.molmed.2012.10.004</doi><tpages>11</tpages></addata></record> |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Autoimmune Diseases - immunology Autoimmune Diseases - metabolism Chemokine CXCL11 - metabolism Chemokine CXCL12 - physiology chemokines CXCL12 CXCR7 G-protein-coupled receptors (GPCRs) Humans Ligands Neoplasms - immunology Neoplasms - metabolism Pathology RDC1 Receptors, CXCR - chemistry Receptors, CXCR - genetics Receptors, CXCR - metabolism seven-transmembrane spanning receptors (7-TMRs) Signal Transduction |
| title | CXCR7 impact on CXCL12 biology and disease |
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