The sesame lignan sesamin attenuates vascular dysfunction in streptozotocin diabetic rats: Involvement of nitric oxide and oxidative stress
The effect of chronic administration of sesamin was studied on aortic reactivity of streptozotocin diabetic rats. Male diabetic rats received sesamin for 7 weeks after diabetes induction. Contractile responses to KCl and phenylephrine and relaxation response to acetylcholine were obtained from aorti...
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| Veröffentlicht in: | European journal of pharmacology 2013-01, Vol.698 (1-3), p.316-321 |
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| container_title | European journal of pharmacology |
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| creator | Baluchnejadmojarad, Tourandokht Roghani, Mehrdad Jalali Nadoushan, Mohammad-Reza Vaez Mahdavi, Mohammad-Reza Kalalian-Moghaddam, Hamid Roghani-Dehkordi, Farshad Dariani, Sharareh Raoufi, Safoura |
| description | The effect of chronic administration of sesamin was studied on aortic reactivity of streptozotocin diabetic rats. Male diabetic rats received sesamin for 7 weeks after diabetes induction. Contractile responses to KCl and phenylephrine and relaxation response to acetylcholine were obtained from aortic rings. Maximum contractile response of endothelium-intact rings to phenylephrine was significantly lower in sesamin-treated diabetic rats relative to untreated diabetics and endothelium removal abolished this difference. Meanwhile, endothelium-dependent relaxation to acetylcholine was significantly higher in sesamin-treated diabetic rats as compared to diabetic ones and pretreatment of rings with nitric oxide synthase inhibitor N(G)-nitro-l-arginine methyl ester significantly attenuated the observed response. Two-month diabetes also resulted in an elevation of malondialdehyde and decreased superoxide dismutase activity and sesamin treatment significantly improved these changes. Therefore, chronic treatment of diabetic rats with sesamin could prevent some abnormal changes in vascular reactivity in diabetic rats through nitric oxide and via attenuation of oxidative stress and tissue integrity of endothelium is necessary for its beneficial effect. |
| doi_str_mv | 10.1016/j.ejphar.2012.09.031 |
| format | Article |
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Male diabetic rats received sesamin for 7 weeks after diabetes induction. Contractile responses to KCl and phenylephrine and relaxation response to acetylcholine were obtained from aortic rings. Maximum contractile response of endothelium-intact rings to phenylephrine was significantly lower in sesamin-treated diabetic rats relative to untreated diabetics and endothelium removal abolished this difference. Meanwhile, endothelium-dependent relaxation to acetylcholine was significantly higher in sesamin-treated diabetic rats as compared to diabetic ones and pretreatment of rings with nitric oxide synthase inhibitor N(G)-nitro-l-arginine methyl ester significantly attenuated the observed response. Two-month diabetes also resulted in an elevation of malondialdehyde and decreased superoxide dismutase activity and sesamin treatment significantly improved these changes. Therefore, chronic treatment of diabetic rats with sesamin could prevent some abnormal changes in vascular reactivity in diabetic rats through nitric oxide and via attenuation of oxidative stress and tissue integrity of endothelium is necessary for its beneficial effect.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/j.ejphar.2012.09.031</identifier><identifier>PMID: 23063541</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>acetylcholine ; Animals ; Aorta ; Aorta - drug effects ; Aorta - metabolism ; Aorta - physiopathology ; diabetes ; Diabetes mellitus ; Diabetes Mellitus, Experimental - metabolism ; Diabetes Mellitus, Experimental - physiopathology ; Dioxoles - pharmacology ; Dose-Response Relationship, Drug ; endothelium ; In Vitro Techniques ; lignans ; Lignans - pharmacology ; Male ; malondialdehyde ; nitric oxide ; Nitric Oxide - metabolism ; nitric oxide synthase ; oxidative stress ; Oxidative Stress - drug effects ; phenylephrine ; potassium chloride ; Prostaglandins - metabolism ; Rats ; Rats, Wistar ; Sesamin ; Sesamum - chemistry ; Streptozotocin ; superoxide dismutase ; Vasoconstriction - drug effects</subject><ispartof>European journal of pharmacology, 2013-01, Vol.698 (1-3), p.316-321</ispartof><rights>2012 Elsevier B.V.</rights><rights>Copyright © 2012 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-e3b65c42981841f1312c8a473a80396aacaacd81e1c2aa221bc420db2e7170633</citedby><cites>FETCH-LOGICAL-c386t-e3b65c42981841f1312c8a473a80396aacaacd81e1c2aa221bc420db2e7170633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejphar.2012.09.031$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23063541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baluchnejadmojarad, Tourandokht</creatorcontrib><creatorcontrib>Roghani, Mehrdad</creatorcontrib><creatorcontrib>Jalali Nadoushan, Mohammad-Reza</creatorcontrib><creatorcontrib>Vaez Mahdavi, Mohammad-Reza</creatorcontrib><creatorcontrib>Kalalian-Moghaddam, Hamid</creatorcontrib><creatorcontrib>Roghani-Dehkordi, Farshad</creatorcontrib><creatorcontrib>Dariani, Sharareh</creatorcontrib><creatorcontrib>Raoufi, Safoura</creatorcontrib><title>The sesame lignan sesamin attenuates vascular dysfunction in streptozotocin diabetic rats: Involvement of nitric oxide and oxidative stress</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The effect of chronic administration of sesamin was studied on aortic reactivity of streptozotocin diabetic rats. Male diabetic rats received sesamin for 7 weeks after diabetes induction. Contractile responses to KCl and phenylephrine and relaxation response to acetylcholine were obtained from aortic rings. Maximum contractile response of endothelium-intact rings to phenylephrine was significantly lower in sesamin-treated diabetic rats relative to untreated diabetics and endothelium removal abolished this difference. Meanwhile, endothelium-dependent relaxation to acetylcholine was significantly higher in sesamin-treated diabetic rats as compared to diabetic ones and pretreatment of rings with nitric oxide synthase inhibitor N(G)-nitro-l-arginine methyl ester significantly attenuated the observed response. Two-month diabetes also resulted in an elevation of malondialdehyde and decreased superoxide dismutase activity and sesamin treatment significantly improved these changes. Therefore, chronic treatment of diabetic rats with sesamin could prevent some abnormal changes in vascular reactivity in diabetic rats through nitric oxide and via attenuation of oxidative stress and tissue integrity of endothelium is necessary for its beneficial effect.</description><subject>acetylcholine</subject><subject>Animals</subject><subject>Aorta</subject><subject>Aorta - drug effects</subject><subject>Aorta - metabolism</subject><subject>Aorta - physiopathology</subject><subject>diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>Dioxoles - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>endothelium</subject><subject>In Vitro Techniques</subject><subject>lignans</subject><subject>Lignans - pharmacology</subject><subject>Male</subject><subject>malondialdehyde</subject><subject>nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>nitric oxide synthase</subject><subject>oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>phenylephrine</subject><subject>potassium chloride</subject><subject>Prostaglandins - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sesamin</subject><subject>Sesamum - chemistry</subject><subject>Streptozotocin</subject><subject>superoxide dismutase</subject><subject>Vasoconstriction - drug effects</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu1TAQhiMEoofCGyDwkk0OHjs3s0CqKi6VKrGgXVsTZ9L6KLEPthNRXoGXxm0KSyRL9sjf_HP5i-I18D1waN4f9nQ43mLYCw5iz9WeS3hS7KBrVclbEE-LHedQlUIpdVK8iPHAOa-VqJ8XJ0LyRtYV7IrfV7fEIkWciU32xqHbIusYpkRuwUSRrRjNMmFgw10cF2eS9Y5lJKZAx-R_-eRNDgeLPSVrWMAUP7ALt_pppZlcYn5kzqaQ__xPOxBDNzy8MNmVHnRifFk8G3GK9OrxPi2uP3-6Ov9aXn77cnF-dlka2TWpJNk3tamE6qCrYAQJwnRYtRI7LlWDaPIZOiAwAlEI6DPMh15QC22eW54W7zbdY_A_FopJzzYamiZ05JeoQbSyrXnNVUarDTXBxxho1MdgZwx3Gri-t0Ef9GaDvrdBc6WzDTntzWOFpZ9p-Jf0d-8ZeLsBI3qNN8FGff09K9TZowqgazLxcSMob2K1FHQ0lpyhwQYySQ_e_r-HPwlyp0E</recordid><startdate>20130105</startdate><enddate>20130105</enddate><creator>Baluchnejadmojarad, Tourandokht</creator><creator>Roghani, Mehrdad</creator><creator>Jalali Nadoushan, Mohammad-Reza</creator><creator>Vaez Mahdavi, Mohammad-Reza</creator><creator>Kalalian-Moghaddam, Hamid</creator><creator>Roghani-Dehkordi, Farshad</creator><creator>Dariani, Sharareh</creator><creator>Raoufi, Safoura</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130105</creationdate><title>The sesame lignan sesamin attenuates vascular dysfunction in streptozotocin diabetic rats: Involvement of nitric oxide and oxidative stress</title><author>Baluchnejadmojarad, Tourandokht ; Roghani, Mehrdad ; Jalali Nadoushan, Mohammad-Reza ; Vaez Mahdavi, Mohammad-Reza ; Kalalian-Moghaddam, Hamid ; Roghani-Dehkordi, Farshad ; Dariani, Sharareh ; Raoufi, Safoura</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-e3b65c42981841f1312c8a473a80396aacaacd81e1c2aa221bc420db2e7170633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>acetylcholine</topic><topic>Animals</topic><topic>Aorta</topic><topic>Aorta - drug effects</topic><topic>Aorta - metabolism</topic><topic>Aorta - physiopathology</topic><topic>diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>Dioxoles - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>endothelium</topic><topic>In Vitro Techniques</topic><topic>lignans</topic><topic>Lignans - pharmacology</topic><topic>Male</topic><topic>malondialdehyde</topic><topic>nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>nitric oxide synthase</topic><topic>oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>phenylephrine</topic><topic>potassium chloride</topic><topic>Prostaglandins - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sesamin</topic><topic>Sesamum - chemistry</topic><topic>Streptozotocin</topic><topic>superoxide dismutase</topic><topic>Vasoconstriction - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baluchnejadmojarad, Tourandokht</creatorcontrib><creatorcontrib>Roghani, Mehrdad</creatorcontrib><creatorcontrib>Jalali Nadoushan, Mohammad-Reza</creatorcontrib><creatorcontrib>Vaez Mahdavi, Mohammad-Reza</creatorcontrib><creatorcontrib>Kalalian-Moghaddam, Hamid</creatorcontrib><creatorcontrib>Roghani-Dehkordi, Farshad</creatorcontrib><creatorcontrib>Dariani, Sharareh</creatorcontrib><creatorcontrib>Raoufi, Safoura</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baluchnejadmojarad, Tourandokht</au><au>Roghani, Mehrdad</au><au>Jalali Nadoushan, Mohammad-Reza</au><au>Vaez Mahdavi, Mohammad-Reza</au><au>Kalalian-Moghaddam, Hamid</au><au>Roghani-Dehkordi, Farshad</au><au>Dariani, Sharareh</au><au>Raoufi, Safoura</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The sesame lignan sesamin attenuates vascular dysfunction in streptozotocin diabetic rats: Involvement of nitric oxide and oxidative stress</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2013-01-05</date><risdate>2013</risdate><volume>698</volume><issue>1-3</issue><spage>316</spage><epage>321</epage><pages>316-321</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>The effect of chronic administration of sesamin was studied on aortic reactivity of streptozotocin diabetic rats. Male diabetic rats received sesamin for 7 weeks after diabetes induction. Contractile responses to KCl and phenylephrine and relaxation response to acetylcholine were obtained from aortic rings. Maximum contractile response of endothelium-intact rings to phenylephrine was significantly lower in sesamin-treated diabetic rats relative to untreated diabetics and endothelium removal abolished this difference. Meanwhile, endothelium-dependent relaxation to acetylcholine was significantly higher in sesamin-treated diabetic rats as compared to diabetic ones and pretreatment of rings with nitric oxide synthase inhibitor N(G)-nitro-l-arginine methyl ester significantly attenuated the observed response. Two-month diabetes also resulted in an elevation of malondialdehyde and decreased superoxide dismutase activity and sesamin treatment significantly improved these changes. Therefore, chronic treatment of diabetic rats with sesamin could prevent some abnormal changes in vascular reactivity in diabetic rats through nitric oxide and via attenuation of oxidative stress and tissue integrity of endothelium is necessary for its beneficial effect.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>23063541</pmid><doi>10.1016/j.ejphar.2012.09.031</doi><tpages>6</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 2013-01, Vol.698 (1-3), p.316-321 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | acetylcholine Animals Aorta Aorta - drug effects Aorta - metabolism Aorta - physiopathology diabetes Diabetes mellitus Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - physiopathology Dioxoles - pharmacology Dose-Response Relationship, Drug endothelium In Vitro Techniques lignans Lignans - pharmacology Male malondialdehyde nitric oxide Nitric Oxide - metabolism nitric oxide synthase oxidative stress Oxidative Stress - drug effects phenylephrine potassium chloride Prostaglandins - metabolism Rats Rats, Wistar Sesamin Sesamum - chemistry Streptozotocin superoxide dismutase Vasoconstriction - drug effects |
| title | The sesame lignan sesamin attenuates vascular dysfunction in streptozotocin diabetic rats: Involvement of nitric oxide and oxidative stress |
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