Post-embolisation susceptibility changes in giant meningiomas: multiparametric histogram analysis using non-contrast-enhanced susceptibility-weighted PRESTO, diffusion-weighted and perfusion-weighted imaging
Purpose To investigate imaging characteristics of post-embolised meningioma and to determine if SW imaging can delineate tumour ischaemia. Materials and methods Sixteen patients were studied before and after preoperative embolisation therapy (8 histopathologically determined with ischaemia, 8 with n...
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| Veröffentlicht in: | European radiology 2013-02, Vol.23 (2), p.551-561 |
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| creator | Nishiguchi, Tomokazu Iwakiri, Takeshi Hayasaki, Kohji Ohsawa, Masahiko Yoneda, Tetuya Mitsuhashi, Yutaka Nishio, Akimasa Dousset, Vincent Miki, Yukio |
| description | Purpose
To investigate imaging characteristics of post-embolised meningioma and to determine if SW imaging can delineate tumour ischaemia.
Materials and methods
Sixteen patients were studied before and after preoperative embolisation therapy (8 histopathologically determined with ischaemia, 8 with non-ischaemia). In each patient, a slice-wise ROI for the entire tumour was established, and histogram variables (mean, SD, minimum, maximum, histogram width, mode, and peak height) of SW, ADC, CBV, CBF, MTT, and TTP maps were compared between ischaemic and non-ischaemic groups. Changes in SW histogram were correlated with histopathological characteristics.
Results
Signal intensity on the SW map tended to decrease in the ischaemic group and partially increased in the non-ischaemic group. A similar trend was observed on the ADC map. The PW histogram showed an MTT increase in ischaemic group; however, CBV did not show significant changes between ischaemic and non-ischaemic groups. Microhaemorrhage was slightly correlated with Δpeak height in the SW histogram.
Conclusion
Post-embolisation changes of intrinsic T2*-weighted MR contrasts on SW map are most likely associated with alterations in deoxyhaemoglobin levels and arterial blood flow.
Key Points
•
Endovascular embolisation is now accepted as an adjuvant therapy for intracranial meningioma.
•
Magnetic resonance imaging is used to assess the effects of embolisation.
•
Unenhanced susceptibility-weighted MRI can delineate ischaemic and non-ischaemic areas.
•
Signal changes at SW imaging are associated with diffusion and perfusion abnormalities.
•
Three-dimensional high-resolution SW imaging offers a new imaging biomarker in assessing ischaemia. |
| doi_str_mv | 10.1007/s00330-012-2618-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1273748135</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2867761231</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-b52c861bd247283677ed51ac9e8f59b6e9066eec13eb2c60c64400c13ad5341b3</originalsourceid><addsrcrecordid>eNp1kc1u1TAQhS0EoreFB2CDLLFhUcP4J4nDrqrKj1SpFZS15ThOrqvEDrYjdJ-SV8KXWyp0JVbWzHxnjsYHoVcU3lGA5n0C4BwIUEZYTSWRT9CGCs4IBSmeog20XJKmbcUJOk3pHgBaKprn6IRxoJRRukG_bkPKxM5dmFzS2QWP05qMXbLr3OTyDput9qNN2Hk8Ou0znq13fnRh1ukDntcpu0VHPdscncFbl3IYS4m119MuuYTXVHDsgycm-Bz13s-Xpcb2R17kp3XjNpf-7derb3c357h3w1D0Rfs40r7Hi43HbTfrsfi8QM8GPSX78uE9Q98_Xt1dfibXN5--XF5cEyO4zKSrmJE17XomGiZ53TS2r6g2rZVD1Xa1baGurTWU246ZGkwtBEApdV9xQTt-ht4e9i4x_Fhtymp25ZRp0t6GNSnKGt4ISXlV0DdH6H1YY_mdPxRwAUxCoeiBMjGkFO2gllhuijtFQe3TVoe0VUlb7dNWsmheP2xeu9n2j4q_8RaAHYBURiXF-I_1f7f-BlgCuyE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1270340280</pqid></control><display><type>article</type><title>Post-embolisation susceptibility changes in giant meningiomas: multiparametric histogram analysis using non-contrast-enhanced susceptibility-weighted PRESTO, diffusion-weighted and perfusion-weighted imaging</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Nishiguchi, Tomokazu ; Iwakiri, Takeshi ; Hayasaki, Kohji ; Ohsawa, Masahiko ; Yoneda, Tetuya ; Mitsuhashi, Yutaka ; Nishio, Akimasa ; Dousset, Vincent ; Miki, Yukio</creator><creatorcontrib>Nishiguchi, Tomokazu ; Iwakiri, Takeshi ; Hayasaki, Kohji ; Ohsawa, Masahiko ; Yoneda, Tetuya ; Mitsuhashi, Yutaka ; Nishio, Akimasa ; Dousset, Vincent ; Miki, Yukio</creatorcontrib><description>Purpose
To investigate imaging characteristics of post-embolised meningioma and to determine if SW imaging can delineate tumour ischaemia.
Materials and methods
Sixteen patients were studied before and after preoperative embolisation therapy (8 histopathologically determined with ischaemia, 8 with non-ischaemia). In each patient, a slice-wise ROI for the entire tumour was established, and histogram variables (mean, SD, minimum, maximum, histogram width, mode, and peak height) of SW, ADC, CBV, CBF, MTT, and TTP maps were compared between ischaemic and non-ischaemic groups. Changes in SW histogram were correlated with histopathological characteristics.
Results
Signal intensity on the SW map tended to decrease in the ischaemic group and partially increased in the non-ischaemic group. A similar trend was observed on the ADC map. The PW histogram showed an MTT increase in ischaemic group; however, CBV did not show significant changes between ischaemic and non-ischaemic groups. Microhaemorrhage was slightly correlated with Δpeak height in the SW histogram.
Conclusion
Post-embolisation changes of intrinsic T2*-weighted MR contrasts on SW map are most likely associated with alterations in deoxyhaemoglobin levels and arterial blood flow.
Key Points
•
Endovascular embolisation is now accepted as an adjuvant therapy for intracranial meningioma.
•
Magnetic resonance imaging is used to assess the effects of embolisation.
•
Unenhanced susceptibility-weighted MRI can delineate ischaemic and non-ischaemic areas.
•
Signal changes at SW imaging are associated with diffusion and perfusion abnormalities.
•
Three-dimensional high-resolution SW imaging offers a new imaging biomarker in assessing ischaemia.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-012-2618-8</identifier><identifier>PMID: 23011211</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Aged ; Biopsy, Needle ; Brain Mapping - methods ; Combined Modality Therapy ; Contrast Media ; Diagnostic Radiology ; Diffusion Magnetic Resonance Imaging - methods ; Embolization ; Embolization, Therapeutic - adverse effects ; Embolization, Therapeutic - methods ; Evaluation Studies as Topic ; Female ; Follow-Up Studies ; Humans ; Hypoxia ; Image Interpretation, Computer-Assisted ; Imaging ; Immunohistochemistry ; Internal Medicine ; Interventional Radiology ; Ischemia ; Male ; Medical imaging ; Medicine ; Medicine & Public Health ; Meningeal Neoplasms - diagnosis ; Meningeal Neoplasms - pathology ; Meningeal Neoplasms - therapy ; Meningioma - diagnosis ; Meningioma - pathology ; Meningioma - therapy ; Middle Aged ; Neoplasm Staging ; Neuro ; Neuroradiology ; Neurosurgical Procedures - methods ; Normal Distribution ; Preoperative Care - methods ; Radiology ; Risk Factors ; Sampling Studies ; Surgery ; Treatment Outcome ; Tumors ; Ultrasound ; University graduates</subject><ispartof>European radiology, 2013-02, Vol.23 (2), p.551-561</ispartof><rights>European Society of Radiology 2012</rights><rights>European Society of Radiology 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-b52c861bd247283677ed51ac9e8f59b6e9066eec13eb2c60c64400c13ad5341b3</citedby><cites>FETCH-LOGICAL-c438t-b52c861bd247283677ed51ac9e8f59b6e9066eec13eb2c60c64400c13ad5341b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-012-2618-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-012-2618-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23011211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nishiguchi, Tomokazu</creatorcontrib><creatorcontrib>Iwakiri, Takeshi</creatorcontrib><creatorcontrib>Hayasaki, Kohji</creatorcontrib><creatorcontrib>Ohsawa, Masahiko</creatorcontrib><creatorcontrib>Yoneda, Tetuya</creatorcontrib><creatorcontrib>Mitsuhashi, Yutaka</creatorcontrib><creatorcontrib>Nishio, Akimasa</creatorcontrib><creatorcontrib>Dousset, Vincent</creatorcontrib><creatorcontrib>Miki, Yukio</creatorcontrib><title>Post-embolisation susceptibility changes in giant meningiomas: multiparametric histogram analysis using non-contrast-enhanced susceptibility-weighted PRESTO, diffusion-weighted and perfusion-weighted imaging</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Purpose
To investigate imaging characteristics of post-embolised meningioma and to determine if SW imaging can delineate tumour ischaemia.
Materials and methods
Sixteen patients were studied before and after preoperative embolisation therapy (8 histopathologically determined with ischaemia, 8 with non-ischaemia). In each patient, a slice-wise ROI for the entire tumour was established, and histogram variables (mean, SD, minimum, maximum, histogram width, mode, and peak height) of SW, ADC, CBV, CBF, MTT, and TTP maps were compared between ischaemic and non-ischaemic groups. Changes in SW histogram were correlated with histopathological characteristics.
Results
Signal intensity on the SW map tended to decrease in the ischaemic group and partially increased in the non-ischaemic group. A similar trend was observed on the ADC map. The PW histogram showed an MTT increase in ischaemic group; however, CBV did not show significant changes between ischaemic and non-ischaemic groups. Microhaemorrhage was slightly correlated with Δpeak height in the SW histogram.
Conclusion
Post-embolisation changes of intrinsic T2*-weighted MR contrasts on SW map are most likely associated with alterations in deoxyhaemoglobin levels and arterial blood flow.
Key Points
•
Endovascular embolisation is now accepted as an adjuvant therapy for intracranial meningioma.
•
Magnetic resonance imaging is used to assess the effects of embolisation.
•
Unenhanced susceptibility-weighted MRI can delineate ischaemic and non-ischaemic areas.
•
Signal changes at SW imaging are associated with diffusion and perfusion abnormalities.
•
Three-dimensional high-resolution SW imaging offers a new imaging biomarker in assessing ischaemia.</description><subject>Adult</subject><subject>Aged</subject><subject>Biopsy, Needle</subject><subject>Brain Mapping - methods</subject><subject>Combined Modality Therapy</subject><subject>Contrast Media</subject><subject>Diagnostic Radiology</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>Embolization</subject><subject>Embolization, Therapeutic - adverse effects</subject><subject>Embolization, Therapeutic - methods</subject><subject>Evaluation Studies as Topic</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Imaging</subject><subject>Immunohistochemistry</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Ischemia</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meningeal Neoplasms - diagnosis</subject><subject>Meningeal Neoplasms - pathology</subject><subject>Meningeal Neoplasms - therapy</subject><subject>Meningioma - diagnosis</subject><subject>Meningioma - pathology</subject><subject>Meningioma - therapy</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Neuro</subject><subject>Neuroradiology</subject><subject>Neurosurgical Procedures - methods</subject><subject>Normal Distribution</subject><subject>Preoperative Care - methods</subject><subject>Radiology</subject><subject>Risk Factors</subject><subject>Sampling Studies</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Ultrasound</subject><subject>University graduates</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc1u1TAQhS0EoreFB2CDLLFhUcP4J4nDrqrKj1SpFZS15ThOrqvEDrYjdJ-SV8KXWyp0JVbWzHxnjsYHoVcU3lGA5n0C4BwIUEZYTSWRT9CGCs4IBSmeog20XJKmbcUJOk3pHgBaKprn6IRxoJRRukG_bkPKxM5dmFzS2QWP05qMXbLr3OTyDput9qNN2Hk8Ou0znq13fnRh1ukDntcpu0VHPdscncFbl3IYS4m119MuuYTXVHDsgycm-Bz13s-Xpcb2R17kp3XjNpf-7derb3c357h3w1D0Rfs40r7Hi43HbTfrsfi8QM8GPSX78uE9Q98_Xt1dfibXN5--XF5cEyO4zKSrmJE17XomGiZ53TS2r6g2rZVD1Xa1baGurTWU246ZGkwtBEApdV9xQTt-ht4e9i4x_Fhtymp25ZRp0t6GNSnKGt4ISXlV0DdH6H1YY_mdPxRwAUxCoeiBMjGkFO2gllhuijtFQe3TVoe0VUlb7dNWsmheP2xeu9n2j4q_8RaAHYBURiXF-I_1f7f-BlgCuyE</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Nishiguchi, Tomokazu</creator><creator>Iwakiri, Takeshi</creator><creator>Hayasaki, Kohji</creator><creator>Ohsawa, Masahiko</creator><creator>Yoneda, Tetuya</creator><creator>Mitsuhashi, Yutaka</creator><creator>Nishio, Akimasa</creator><creator>Dousset, Vincent</creator><creator>Miki, Yukio</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20130201</creationdate><title>Post-embolisation susceptibility changes in giant meningiomas: multiparametric histogram analysis using non-contrast-enhanced susceptibility-weighted PRESTO, diffusion-weighted and perfusion-weighted imaging</title><author>Nishiguchi, Tomokazu ; Iwakiri, Takeshi ; Hayasaki, Kohji ; Ohsawa, Masahiko ; Yoneda, Tetuya ; Mitsuhashi, Yutaka ; Nishio, Akimasa ; Dousset, Vincent ; Miki, Yukio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-b52c861bd247283677ed51ac9e8f59b6e9066eec13eb2c60c64400c13ad5341b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biopsy, Needle</topic><topic>Brain Mapping - methods</topic><topic>Combined Modality Therapy</topic><topic>Contrast Media</topic><topic>Diagnostic Radiology</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>Embolization</topic><topic>Embolization, Therapeutic - adverse effects</topic><topic>Embolization, Therapeutic - methods</topic><topic>Evaluation Studies as Topic</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Imaging</topic><topic>Immunohistochemistry</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Ischemia</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meningeal Neoplasms - diagnosis</topic><topic>Meningeal Neoplasms - pathology</topic><topic>Meningeal Neoplasms - therapy</topic><topic>Meningioma - diagnosis</topic><topic>Meningioma - pathology</topic><topic>Meningioma - therapy</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Neuro</topic><topic>Neuroradiology</topic><topic>Neurosurgical Procedures - methods</topic><topic>Normal Distribution</topic><topic>Preoperative Care - methods</topic><topic>Radiology</topic><topic>Risk Factors</topic><topic>Sampling Studies</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Ultrasound</topic><topic>University graduates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishiguchi, Tomokazu</creatorcontrib><creatorcontrib>Iwakiri, Takeshi</creatorcontrib><creatorcontrib>Hayasaki, Kohji</creatorcontrib><creatorcontrib>Ohsawa, Masahiko</creatorcontrib><creatorcontrib>Yoneda, Tetuya</creatorcontrib><creatorcontrib>Mitsuhashi, Yutaka</creatorcontrib><creatorcontrib>Nishio, Akimasa</creatorcontrib><creatorcontrib>Dousset, Vincent</creatorcontrib><creatorcontrib>Miki, Yukio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishiguchi, Tomokazu</au><au>Iwakiri, Takeshi</au><au>Hayasaki, Kohji</au><au>Ohsawa, Masahiko</au><au>Yoneda, Tetuya</au><au>Mitsuhashi, Yutaka</au><au>Nishio, Akimasa</au><au>Dousset, Vincent</au><au>Miki, Yukio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-embolisation susceptibility changes in giant meningiomas: multiparametric histogram analysis using non-contrast-enhanced susceptibility-weighted PRESTO, diffusion-weighted and perfusion-weighted imaging</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>23</volume><issue>2</issue><spage>551</spage><epage>561</epage><pages>551-561</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Purpose
To investigate imaging characteristics of post-embolised meningioma and to determine if SW imaging can delineate tumour ischaemia.
Materials and methods
Sixteen patients were studied before and after preoperative embolisation therapy (8 histopathologically determined with ischaemia, 8 with non-ischaemia). In each patient, a slice-wise ROI for the entire tumour was established, and histogram variables (mean, SD, minimum, maximum, histogram width, mode, and peak height) of SW, ADC, CBV, CBF, MTT, and TTP maps were compared between ischaemic and non-ischaemic groups. Changes in SW histogram were correlated with histopathological characteristics.
Results
Signal intensity on the SW map tended to decrease in the ischaemic group and partially increased in the non-ischaemic group. A similar trend was observed on the ADC map. The PW histogram showed an MTT increase in ischaemic group; however, CBV did not show significant changes between ischaemic and non-ischaemic groups. Microhaemorrhage was slightly correlated with Δpeak height in the SW histogram.
Conclusion
Post-embolisation changes of intrinsic T2*-weighted MR contrasts on SW map are most likely associated with alterations in deoxyhaemoglobin levels and arterial blood flow.
Key Points
•
Endovascular embolisation is now accepted as an adjuvant therapy for intracranial meningioma.
•
Magnetic resonance imaging is used to assess the effects of embolisation.
•
Unenhanced susceptibility-weighted MRI can delineate ischaemic and non-ischaemic areas.
•
Signal changes at SW imaging are associated with diffusion and perfusion abnormalities.
•
Three-dimensional high-resolution SW imaging offers a new imaging biomarker in assessing ischaemia.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>23011211</pmid><doi>10.1007/s00330-012-2618-8</doi><tpages>11</tpages></addata></record> |
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| ispartof | European radiology, 2013-02, Vol.23 (2), p.551-561 |
| issn | 0938-7994 1432-1084 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Biopsy, Needle Brain Mapping - methods Combined Modality Therapy Contrast Media Diagnostic Radiology Diffusion Magnetic Resonance Imaging - methods Embolization Embolization, Therapeutic - adverse effects Embolization, Therapeutic - methods Evaluation Studies as Topic Female Follow-Up Studies Humans Hypoxia Image Interpretation, Computer-Assisted Imaging Immunohistochemistry Internal Medicine Interventional Radiology Ischemia Male Medical imaging Medicine Medicine & Public Health Meningeal Neoplasms - diagnosis Meningeal Neoplasms - pathology Meningeal Neoplasms - therapy Meningioma - diagnosis Meningioma - pathology Meningioma - therapy Middle Aged Neoplasm Staging Neuro Neuroradiology Neurosurgical Procedures - methods Normal Distribution Preoperative Care - methods Radiology Risk Factors Sampling Studies Surgery Treatment Outcome Tumors Ultrasound University graduates |
| title | Post-embolisation susceptibility changes in giant meningiomas: multiparametric histogram analysis using non-contrast-enhanced susceptibility-weighted PRESTO, diffusion-weighted and perfusion-weighted imaging |
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