Number and sequence of preceding miscarriages and maternal age for the prediction of antiphospholipid syndrome in women with recurrent miscarriage
Objective To investigate the relationship between the number and sequence of preceding miscarriages and antiphospholipid syndrome (APS). Design Retrospective cohort study. Setting Recurrent miscarriage (RM) clinic. Patient(s) Women who attended the RM clinic from 1988 to 2006. Intervention(s) None....
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| Veröffentlicht in: | Fertility and sterility 2013, Vol.99 (1), p.188-192 |
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| creator | van den Boogaard, Emmy, M.D Cohn, Danny M., M.D., Ph.D Korevaar, Johanna C., Ph.D Dawood, Feroza, M.D., Ph.D Vissenberg, Rosa, M.D Middeldorp, Saskia, M.D., Ph.D Goddijn, Mariette, Ph.D Farquharson, Roy G., M.D |
| description | Objective To investigate the relationship between the number and sequence of preceding miscarriages and antiphospholipid syndrome (APS). Design Retrospective cohort study. Setting Recurrent miscarriage (RM) clinic. Patient(s) Women who attended the RM clinic from 1988 to 2006. Intervention(s) None. Main Outcome Measure(s) Number, type, and sequence of previous pregnancies were compared between women with APS and women with unexplained RM. Result(s) A total of 1,719 patients were included; 312 (18%) had APS, and 1,407 (82%) had unexplained RM. The mean maternal age (32.6 years) did not differ between women with and without APS. The median number of miscarriages was three in both groups. A total of 865 women (50%) had a history of at least one live birth, with no difference between the two groups. In both groups, 97% of the women had a history of consecutive miscarriages. Conclusion(s) The number of preceding miscarriage, type and sequence of previous pregnancies, and maternal age were not associated with APS in women with RM. There is no increased diagnostic yield for APS after three miscarriages rather than after two miscarriages and no increased diagnostic yield for APS after consecutive miscarriages rather than after nonconsecutive miscarriages. Therefore, APS testing should be considered for all women with two or more miscarriages. |
| doi_str_mv | 10.1016/j.fertnstert.2012.09.002 |
| format | Article |
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Design Retrospective cohort study. Setting Recurrent miscarriage (RM) clinic. Patient(s) Women who attended the RM clinic from 1988 to 2006. Intervention(s) None. Main Outcome Measure(s) Number, type, and sequence of previous pregnancies were compared between women with APS and women with unexplained RM. Result(s) A total of 1,719 patients were included; 312 (18%) had APS, and 1,407 (82%) had unexplained RM. The mean maternal age (32.6 years) did not differ between women with and without APS. The median number of miscarriages was three in both groups. A total of 865 women (50%) had a history of at least one live birth, with no difference between the two groups. In both groups, 97% of the women had a history of consecutive miscarriages. Conclusion(s) The number of preceding miscarriage, type and sequence of previous pregnancies, and maternal age were not associated with APS in women with RM. There is no increased diagnostic yield for APS after three miscarriages rather than after two miscarriages and no increased diagnostic yield for APS after consecutive miscarriages rather than after nonconsecutive miscarriages. Therefore, APS testing should be considered for all women with two or more miscarriages.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2012.09.002</identifier><identifier>PMID: 23043688</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>abortion (animals) ; Abortion, Habitual - epidemiology ; Adult ; Age Factors ; Antiphospholipid syndrome ; Antiphospholipid Syndrome - complications ; Antiphospholipid Syndrome - diagnosis ; Cohort Studies ; Female ; Humans ; Incidence ; Internal Medicine ; Mass Screening ; Maternal Age ; obstetric history ; Obstetrics and Gynecology ; patients ; prediction ; Predictive Value of Tests ; Pregnancy ; recurrent miscarriage ; Retrospective Studies ; Risk Factors ; women</subject><ispartof>Fertility and sterility, 2013, Vol.99 (1), p.188-192</ispartof><rights>American Society for Reproductive Medicine</rights><rights>2013 American Society for Reproductive Medicine</rights><rights>Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-f50225981a040b1a0aec595a9accd0fca6fbac65c6f753778f6b15852bc00f483</citedby><cites>FETCH-LOGICAL-c503t-f50225981a040b1a0aec595a9accd0fca6fbac65c6f753778f6b15852bc00f483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fertnstert.2012.09.002$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23043688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van den Boogaard, Emmy, M.D</creatorcontrib><creatorcontrib>Cohn, Danny M., M.D., Ph.D</creatorcontrib><creatorcontrib>Korevaar, Johanna C., Ph.D</creatorcontrib><creatorcontrib>Dawood, Feroza, M.D., Ph.D</creatorcontrib><creatorcontrib>Vissenberg, Rosa, M.D</creatorcontrib><creatorcontrib>Middeldorp, Saskia, M.D., Ph.D</creatorcontrib><creatorcontrib>Goddijn, Mariette, Ph.D</creatorcontrib><creatorcontrib>Farquharson, Roy G., M.D</creatorcontrib><title>Number and sequence of preceding miscarriages and maternal age for the prediction of antiphospholipid syndrome in women with recurrent miscarriage</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective To investigate the relationship between the number and sequence of preceding miscarriages and antiphospholipid syndrome (APS). Design Retrospective cohort study. Setting Recurrent miscarriage (RM) clinic. Patient(s) Women who attended the RM clinic from 1988 to 2006. Intervention(s) None. Main Outcome Measure(s) Number, type, and sequence of previous pregnancies were compared between women with APS and women with unexplained RM. Result(s) A total of 1,719 patients were included; 312 (18%) had APS, and 1,407 (82%) had unexplained RM. The mean maternal age (32.6 years) did not differ between women with and without APS. The median number of miscarriages was three in both groups. A total of 865 women (50%) had a history of at least one live birth, with no difference between the two groups. In both groups, 97% of the women had a history of consecutive miscarriages. Conclusion(s) The number of preceding miscarriage, type and sequence of previous pregnancies, and maternal age were not associated with APS in women with RM. There is no increased diagnostic yield for APS after three miscarriages rather than after two miscarriages and no increased diagnostic yield for APS after consecutive miscarriages rather than after nonconsecutive miscarriages. Therefore, APS testing should be considered for all women with two or more miscarriages.</description><subject>abortion (animals)</subject><subject>Abortion, Habitual - epidemiology</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Antiphospholipid syndrome</subject><subject>Antiphospholipid Syndrome - complications</subject><subject>Antiphospholipid Syndrome - diagnosis</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Internal Medicine</subject><subject>Mass Screening</subject><subject>Maternal Age</subject><subject>obstetric history</subject><subject>Obstetrics and Gynecology</subject><subject>patients</subject><subject>prediction</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>recurrent miscarriage</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>women</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUk2P1DAMrRCInV34C5AjlxYnnfTjggQrWJBWcFj2HKWpM5OhTUrSLpq_wS_GZZYPceIQW4qe37P9nGWMQ8GBVy8PhcU4-zRTLARwUUBbAIgH2YZLWeWykuXDbAPAZQ6iEWfZeUoHAKh4LR5nZ6KEbVk1zSb7_nEZO4xM-54l_LqgN8iCZVNEg73zOza6ZHSMTu8w_YSNmmS9Hhj9MBsim_e44ntnZhf8Wq397KZ9SPQGNzmiPvo-hhGZ8-wbZYpu3jMSWWJEP_-t8iR7ZPWQ8Ol9vshu3739fPk-v_509eHy9XVuJJRzbiUIIduGa9hCR1Gjka3UrTamB2t0ZTttKmkqW8uyrhtbdVw2UnQGwG6b8iJ7ceKdYqDB06zWJnAYtMewJMVFXdbbUpacoM0JamJIKaJVU3SjjkfFQa2OqIP644haHVHQKnKESp_dqyzdiP3vwl8WEOD5CWB1UHoXXVK3N8QgyT3R1LwkxJsTAmkbdw6jSsatRvWOFjirPrj_6ePVPyRmcN4ZPXzBI6ZDWFZPaWqVqEbdrLezng4XIHhDBD8AUlPEJw</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>van den Boogaard, Emmy, M.D</creator><creator>Cohn, Danny M., M.D., Ph.D</creator><creator>Korevaar, Johanna C., Ph.D</creator><creator>Dawood, Feroza, M.D., Ph.D</creator><creator>Vissenberg, Rosa, M.D</creator><creator>Middeldorp, Saskia, M.D., Ph.D</creator><creator>Goddijn, Mariette, Ph.D</creator><creator>Farquharson, Roy G., M.D</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2013</creationdate><title>Number and sequence of preceding miscarriages and maternal age for the prediction of antiphospholipid syndrome in women with recurrent miscarriage</title><author>van den Boogaard, Emmy, M.D ; Cohn, Danny M., M.D., Ph.D ; Korevaar, Johanna C., Ph.D ; Dawood, Feroza, M.D., Ph.D ; Vissenberg, Rosa, M.D ; Middeldorp, Saskia, M.D., Ph.D ; Goddijn, Mariette, Ph.D ; Farquharson, Roy G., M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-f50225981a040b1a0aec595a9accd0fca6fbac65c6f753778f6b15852bc00f483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>abortion (animals)</topic><topic>Abortion, Habitual - epidemiology</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Antiphospholipid syndrome</topic><topic>Antiphospholipid Syndrome - complications</topic><topic>Antiphospholipid Syndrome - diagnosis</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Internal Medicine</topic><topic>Mass Screening</topic><topic>Maternal Age</topic><topic>obstetric history</topic><topic>Obstetrics and Gynecology</topic><topic>patients</topic><topic>prediction</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>recurrent miscarriage</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van den Boogaard, Emmy, M.D</creatorcontrib><creatorcontrib>Cohn, Danny M., M.D., Ph.D</creatorcontrib><creatorcontrib>Korevaar, Johanna C., Ph.D</creatorcontrib><creatorcontrib>Dawood, Feroza, M.D., Ph.D</creatorcontrib><creatorcontrib>Vissenberg, Rosa, M.D</creatorcontrib><creatorcontrib>Middeldorp, Saskia, M.D., Ph.D</creatorcontrib><creatorcontrib>Goddijn, Mariette, Ph.D</creatorcontrib><creatorcontrib>Farquharson, Roy G., M.D</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van den Boogaard, Emmy, M.D</au><au>Cohn, Danny M., M.D., Ph.D</au><au>Korevaar, Johanna C., Ph.D</au><au>Dawood, Feroza, M.D., Ph.D</au><au>Vissenberg, Rosa, M.D</au><au>Middeldorp, Saskia, M.D., Ph.D</au><au>Goddijn, Mariette, Ph.D</au><au>Farquharson, Roy G., M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Number and sequence of preceding miscarriages and maternal age for the prediction of antiphospholipid syndrome in women with recurrent miscarriage</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2013</date><risdate>2013</risdate><volume>99</volume><issue>1</issue><spage>188</spage><epage>192</epage><pages>188-192</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><abstract>Objective To investigate the relationship between the number and sequence of preceding miscarriages and antiphospholipid syndrome (APS). Design Retrospective cohort study. Setting Recurrent miscarriage (RM) clinic. Patient(s) Women who attended the RM clinic from 1988 to 2006. Intervention(s) None. Main Outcome Measure(s) Number, type, and sequence of previous pregnancies were compared between women with APS and women with unexplained RM. Result(s) A total of 1,719 patients were included; 312 (18%) had APS, and 1,407 (82%) had unexplained RM. The mean maternal age (32.6 years) did not differ between women with and without APS. The median number of miscarriages was three in both groups. A total of 865 women (50%) had a history of at least one live birth, with no difference between the two groups. In both groups, 97% of the women had a history of consecutive miscarriages. Conclusion(s) The number of preceding miscarriage, type and sequence of previous pregnancies, and maternal age were not associated with APS in women with RM. There is no increased diagnostic yield for APS after three miscarriages rather than after two miscarriages and no increased diagnostic yield for APS after consecutive miscarriages rather than after nonconsecutive miscarriages. Therefore, APS testing should be considered for all women with two or more miscarriages.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23043688</pmid><doi>10.1016/j.fertnstert.2012.09.002</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | abortion (animals) Abortion, Habitual - epidemiology Adult Age Factors Antiphospholipid syndrome Antiphospholipid Syndrome - complications Antiphospholipid Syndrome - diagnosis Cohort Studies Female Humans Incidence Internal Medicine Mass Screening Maternal Age obstetric history Obstetrics and Gynecology patients prediction Predictive Value of Tests Pregnancy recurrent miscarriage Retrospective Studies Risk Factors women |
| title | Number and sequence of preceding miscarriages and maternal age for the prediction of antiphospholipid syndrome in women with recurrent miscarriage |
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