Proteome-wide study of endoplasmic reticulum stress induced by thapsigargin in N2a neuroblastoma cells

► Strong crosstalk between mitochondria and endoplasmic reticulum. ► Upregulated mitochondrial enzymes during endoplasmic reticulum stress. ► Potentially atypical functions of Grp78 in controlling endoplasmic reticulum stress. Disturbances in intraluminal endoplasmic reticulum (ER) Ca2+ concentratio...

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Veröffentlicht in:	Neurochemistry international 2013-01, Vol.62 (1), p.58-69
Hauptverfasser:	Földi, István, Tóth, Anikó M., Szabó, Zoltán, Mózes, Emese, Berkecz, Róbert, Datki, Zsolt L., Penke, Botond, Janáky, Tamás
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioenergetics Biological and medical sciences Blotting, Western Cell Line, Tumor Cell Survival - drug effects Cells, Cultured Electrophoresis, Gel, Two-Dimensional Endoplasmic reticulum stress Endoplasmic Reticulum Stress - drug effects Endoplasmic Reticulum Stress - genetics Energy Metabolism - drug effects Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Grp78 Heat-Shock Proteins - biosynthesis Heat-Shock Proteins - genetics Humans Image Processing, Computer-Assisted Mitochondria - drug effects Mitochondria - metabolism Molecular Chaperones - metabolism Neurites - drug effects Neuroblastoma - pathology Neurodegenerative disorder Proteome - genetics Proteomics Spectrum Analysis Thapsigargin Thapsigargin - pharmacology Two-dimensional electrophoresis Vertebrates: nervous system and sense organs
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