Shared Gene Regulation during Human Somatic Cell Reprogramming

Human induced pluripotent stem (iPS) cells have the ability to differentiate into all somatic cells and to maintain unlimited self-renewal. Therefore, they have great potential in both basic research and clinical therapy for many diseases. To identify potentially universal mechanisms of human somati...

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Veröffentlicht in:	Journal of genetics and genomics 2012-12, Vol.39 (12), p.613-623
Hauptverfasser:	Wang, Xiang, Chen, Xuesong, Zhang, Huijun, Qin, Wenyi, Xue, Yan, Zeng, Fanyi
Format:	Artikel
Sprache:	eng
Schlagworte:	Cluster Analysis Embryonic Stem Cells - metabolism Embryos Fetal Blood - cytology Fetal Blood - metabolism Fibroblasts - cytology Fibroblasts - metabolism Gene expression profile Gene Expression Profiling gene expression regulation Gene regulation Gene Regulatory Networks genes Human iPS cells Humans Induced Pluripotent Stem Cells - metabolism Keratinocytes - cytology Keratinocytes - metabolism microRNA MicroRNAs - genetics miRNA Network analysis Oct-4 protein Oligonucleotide Array Sequence Analysis Pluripotent Stem Cells - metabolism proteins Somatic cell reprogramming Somatic cells Stem cells 人类体细胞共享基因调控多能干细胞编程过程蛋白质相互作用
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