Diffusion-weighted MR imaging including bi-exponential fitting for the detection of recurrent or residual tumour after (chemo)radiotherapy for laryngeal and hypopharyngeal cancers
Objectives To assess whether diffusion-weighted magnetic resonance imaging (DW-MRI) including bi-exponential fitting helps to detect residual/recurrent tumours after (chemo)radiotherapy of laryngeal and hypopharyngeal carcinoma. Methods Forty-six patients with newly-developed/worsening symptoms afte...
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| Veröffentlicht in: | European radiology 2013-02, Vol.23 (2), p.562-569 |
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| creator | Tshering Vogel, Dechen W. Zbaeren, Peter Geretschlaeger, Andreas Vermathen, Peter De Keyzer, Frederik Thoeny, Harriet C. |
| description | Objectives
To assess whether diffusion-weighted magnetic resonance imaging (DW-MRI) including bi-exponential fitting helps to detect residual/recurrent tumours after (chemo)radiotherapy of laryngeal and hypopharyngeal carcinoma.
Methods
Forty-six patients with newly-developed/worsening symptoms after (chemo)radiotherapy for laryngeal/hypopharyngeal cancers were prospectively imaged using conventional MRI and axial DW-MRI. Qualitative (visual assessment) and quantitative analysis (mono-exponentially: total apparent diffusion coefficient [ADC
T
], and bi-exponentially: perfusion fraction [F
P
] and true diffusion coefficient [ADC
D
]) were performed. Diffusion parameters of tumour versus post-therapeutic changes were compared, with final diagnosis based on histopathology and follow-up. Mann-Whitney
U
test was used for statistical analysis.
Results
Qualitative DW-MRI combined with morphological images allowed the detection of tumour with a sensitivity of 94% and specificity 100%. ADC
T
and ADC
D
values were lower in tumour with values 120 ± 49 × 10
−5
mm
2
/s and 113 ± 50 × 10
−5
mm
2
/s, respectively, compared with post-therapeutic changes with values 182 ± 41 × 10
−5
mm
2
/s (
P
|
| doi_str_mv | 10.1007/s00330-012-2596-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1273737412</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2867761101</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-4828a0e96cb4d92533e63126f58c21d098348f27585649c59408a13c928eab6a3</originalsourceid><addsrcrecordid>eNp1kcuKFDEUhoMoTtv6AG4k4GZcRHOrqmQp4xVGBNF1kU6ddGWoTsokhd3P5QuassdBBAkk4Zzv_3P5EXrK6EtGafcqUyoEJZRxwhvdkuM9tGFScMKokvfRhmqhSKe1vECPcr6hlGomu4fognPVNryjG_TzjXduyT4G8gP8fiww4E9fsD-YvQ977IOdlmHd7TyB4xwDhOLNhJ0vZS27mHAZAQ9QwJZqg6PDCeySUiVx7SbIfliqpCyHuCRsXIGEL-0Ih_gimcHHqk9mPv32mkw6hT1U3IQBj6c5zuNdyZpgIeXH6IEzU4Ynt-sWfXv39uvVB3L9-f3Hq9fXxErWFCIVV4aCbu1ODpo3QkArGG9doyxnA9VKSOV416imldo2WlJlmLCaKzC71ogtujz7zil-XyCX_uCzhWkyAeKSe8Y7UYdkvKLP_0Fv6ltDvd1KUSHpOm8RO1M2xZwTuH5O9afTqWe0XxPtz4n2NdF-TbQ_Vs2zW-dld4DhTvEnwgrwM5Brq_5T-uvo_7r-Aq_CrzA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1270340270</pqid></control><display><type>article</type><title>Diffusion-weighted MR imaging including bi-exponential fitting for the detection of recurrent or residual tumour after (chemo)radiotherapy for laryngeal and hypopharyngeal cancers</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Tshering Vogel, Dechen W. ; Zbaeren, Peter ; Geretschlaeger, Andreas ; Vermathen, Peter ; De Keyzer, Frederik ; Thoeny, Harriet C.</creator><creatorcontrib>Tshering Vogel, Dechen W. ; Zbaeren, Peter ; Geretschlaeger, Andreas ; Vermathen, Peter ; De Keyzer, Frederik ; Thoeny, Harriet C.</creatorcontrib><description>Objectives
To assess whether diffusion-weighted magnetic resonance imaging (DW-MRI) including bi-exponential fitting helps to detect residual/recurrent tumours after (chemo)radiotherapy of laryngeal and hypopharyngeal carcinoma.
Methods
Forty-six patients with newly-developed/worsening symptoms after (chemo)radiotherapy for laryngeal/hypopharyngeal cancers were prospectively imaged using conventional MRI and axial DW-MRI. Qualitative (visual assessment) and quantitative analysis (mono-exponentially: total apparent diffusion coefficient [ADC
T
], and bi-exponentially: perfusion fraction [F
P
] and true diffusion coefficient [ADC
D
]) were performed. Diffusion parameters of tumour versus post-therapeutic changes were compared, with final diagnosis based on histopathology and follow-up. Mann-Whitney
U
test was used for statistical analysis.
Results
Qualitative DW-MRI combined with morphological images allowed the detection of tumour with a sensitivity of 94% and specificity 100%. ADC
T
and ADC
D
values were lower in tumour with values 120 ± 49 × 10
−5
mm
2
/s and 113 ± 50 × 10
−5
mm
2
/s, respectively, compared with post-therapeutic changes with values 182 ± 41 × 10
−5
mm
2
/s (
P
< 0.0002) and 160 ± 47 × 10
−5
mm
2
/s (
P
< 0.003), respectively. F
P
values were significantly lower in tumours than in non-tumours (13 ± 9% versus 31 ± 16%,
P
< 0.0002), with F
P
being the best quantitative parameter for differentiation between post-therapeutic changes and recurrence.
Conclusions
DW-MRI in combination with conventional MRI substantially improves detection and exclusion of tumour in patients with laryngeal and hypopharyngeal cancers after treatment with (chemo)radiotherapy on both qualitative and quantitative analysis, with F
P
being the best quantitative parameter in this context.
Key Points
•
DW-MRI is increasingly used to detect tumour recurrence.
•
DW-MRI allows accurate post-treatment recurrence detection in laryngeal or hypopharyngeal cancer
•
ADC values in recurrent tumour are lower than in benign tissue alterations
•
Both qualitative and quantitative DW-MRI approaches allow detection of recurrence
•
DW-MRI can easily be added to daily clinical routine imaging</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-012-2596-x</identifier><identifier>PMID: 22865270</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Aged ; Aged, 80 and over ; Biopsy ; Biopsy, Needle ; Cancer therapies ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - therapy ; Chemoradiotherapy - methods ; Cohort Studies ; Diagnostic Radiology ; Diffusion Magnetic Resonance Imaging - methods ; Edema ; Female ; Head and Neck ; Head and Neck Neoplasms - diagnosis ; Head and Neck Neoplasms - mortality ; Head and Neck Neoplasms - therapy ; Humans ; Hypopharyngeal Neoplasms - diagnosis ; Hypopharyngeal Neoplasms - mortality ; Hypopharyngeal Neoplasms - therapy ; Imaging ; Immunohistochemistry ; Internal Medicine ; Interventional Radiology ; Laryngeal Neoplasms - diagnosis ; Laryngeal Neoplasms - mortality ; Laryngeal Neoplasms - therapy ; Laryngoscopy ; Larynx ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Recurrence, Local - diagnosis ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - pathology ; Neoplasm, Residual - diagnosis ; Neoplasm, Residual - mortality ; Neoplasm, Residual - pathology ; Neuroradiology ; Patients ; Prognosis ; Prospective Studies ; Quality of life ; Quantitative analysis ; Radiation therapy ; Radiology ; Risk Assessment ; ROC Curve ; Squamous Cell Carcinoma of Head and Neck ; Statistics, Nonparametric ; Surgery ; Survival Rate ; Tumors ; Ultrasound</subject><ispartof>European radiology, 2013-02, Vol.23 (2), p.562-569</ispartof><rights>European Society of Radiology 2012</rights><rights>European Society of Radiology 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-4828a0e96cb4d92533e63126f58c21d098348f27585649c59408a13c928eab6a3</citedby><cites>FETCH-LOGICAL-c415t-4828a0e96cb4d92533e63126f58c21d098348f27585649c59408a13c928eab6a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-012-2596-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-012-2596-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22865270$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tshering Vogel, Dechen W.</creatorcontrib><creatorcontrib>Zbaeren, Peter</creatorcontrib><creatorcontrib>Geretschlaeger, Andreas</creatorcontrib><creatorcontrib>Vermathen, Peter</creatorcontrib><creatorcontrib>De Keyzer, Frederik</creatorcontrib><creatorcontrib>Thoeny, Harriet C.</creatorcontrib><title>Diffusion-weighted MR imaging including bi-exponential fitting for the detection of recurrent or residual tumour after (chemo)radiotherapy for laryngeal and hypopharyngeal cancers</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objectives
To assess whether diffusion-weighted magnetic resonance imaging (DW-MRI) including bi-exponential fitting helps to detect residual/recurrent tumours after (chemo)radiotherapy of laryngeal and hypopharyngeal carcinoma.
Methods
Forty-six patients with newly-developed/worsening symptoms after (chemo)radiotherapy for laryngeal/hypopharyngeal cancers were prospectively imaged using conventional MRI and axial DW-MRI. Qualitative (visual assessment) and quantitative analysis (mono-exponentially: total apparent diffusion coefficient [ADC
T
], and bi-exponentially: perfusion fraction [F
P
] and true diffusion coefficient [ADC
D
]) were performed. Diffusion parameters of tumour versus post-therapeutic changes were compared, with final diagnosis based on histopathology and follow-up. Mann-Whitney
U
test was used for statistical analysis.
Results
Qualitative DW-MRI combined with morphological images allowed the detection of tumour with a sensitivity of 94% and specificity 100%. ADC
T
and ADC
D
values were lower in tumour with values 120 ± 49 × 10
−5
mm
2
/s and 113 ± 50 × 10
−5
mm
2
/s, respectively, compared with post-therapeutic changes with values 182 ± 41 × 10
−5
mm
2
/s (
P
< 0.0002) and 160 ± 47 × 10
−5
mm
2
/s (
P
< 0.003), respectively. F
P
values were significantly lower in tumours than in non-tumours (13 ± 9% versus 31 ± 16%,
P
< 0.0002), with F
P
being the best quantitative parameter for differentiation between post-therapeutic changes and recurrence.
Conclusions
DW-MRI in combination with conventional MRI substantially improves detection and exclusion of tumour in patients with laryngeal and hypopharyngeal cancers after treatment with (chemo)radiotherapy on both qualitative and quantitative analysis, with F
P
being the best quantitative parameter in this context.
Key Points
•
DW-MRI is increasingly used to detect tumour recurrence.
•
DW-MRI allows accurate post-treatment recurrence detection in laryngeal or hypopharyngeal cancer
•
ADC values in recurrent tumour are lower than in benign tissue alterations
•
Both qualitative and quantitative DW-MRI approaches allow detection of recurrence
•
DW-MRI can easily be added to daily clinical routine imaging</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biopsy</subject><subject>Biopsy, Needle</subject><subject>Cancer therapies</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Chemoradiotherapy - methods</subject><subject>Cohort Studies</subject><subject>Diagnostic Radiology</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>Edema</subject><subject>Female</subject><subject>Head and Neck</subject><subject>Head and Neck Neoplasms - diagnosis</subject><subject>Head and Neck Neoplasms - mortality</subject><subject>Head and Neck Neoplasms - therapy</subject><subject>Humans</subject><subject>Hypopharyngeal Neoplasms - diagnosis</subject><subject>Hypopharyngeal Neoplasms - mortality</subject><subject>Hypopharyngeal Neoplasms - therapy</subject><subject>Imaging</subject><subject>Immunohistochemistry</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Laryngeal Neoplasms - diagnosis</subject><subject>Laryngeal Neoplasms - mortality</subject><subject>Laryngeal Neoplasms - therapy</subject><subject>Laryngoscopy</subject><subject>Larynx</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - diagnosis</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm, Residual - diagnosis</subject><subject>Neoplasm, Residual - mortality</subject><subject>Neoplasm, Residual - pathology</subject><subject>Neuroradiology</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Quality of life</subject><subject>Quantitative analysis</subject><subject>Radiation therapy</subject><subject>Radiology</subject><subject>Risk Assessment</subject><subject>ROC Curve</subject><subject>Squamous Cell Carcinoma of Head and Neck</subject><subject>Statistics, Nonparametric</subject><subject>Surgery</subject><subject>Survival Rate</subject><subject>Tumors</subject><subject>Ultrasound</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kcuKFDEUhoMoTtv6AG4k4GZcRHOrqmQp4xVGBNF1kU6ddGWoTsokhd3P5QuassdBBAkk4Zzv_3P5EXrK6EtGafcqUyoEJZRxwhvdkuM9tGFScMKokvfRhmqhSKe1vECPcr6hlGomu4fognPVNryjG_TzjXduyT4G8gP8fiww4E9fsD-YvQ977IOdlmHd7TyB4xwDhOLNhJ0vZS27mHAZAQ9QwJZqg6PDCeySUiVx7SbIfliqpCyHuCRsXIGEL-0Ih_gimcHHqk9mPv32mkw6hT1U3IQBj6c5zuNdyZpgIeXH6IEzU4Ynt-sWfXv39uvVB3L9-f3Hq9fXxErWFCIVV4aCbu1ODpo3QkArGG9doyxnA9VKSOV416imldo2WlJlmLCaKzC71ogtujz7zil-XyCX_uCzhWkyAeKSe8Y7UYdkvKLP_0Fv6ltDvd1KUSHpOm8RO1M2xZwTuH5O9afTqWe0XxPtz4n2NdF-TbQ_Vs2zW-dld4DhTvEnwgrwM5Brq_5T-uvo_7r-Aq_CrzA</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Tshering Vogel, Dechen W.</creator><creator>Zbaeren, Peter</creator><creator>Geretschlaeger, Andreas</creator><creator>Vermathen, Peter</creator><creator>De Keyzer, Frederik</creator><creator>Thoeny, Harriet C.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20130201</creationdate><title>Diffusion-weighted MR imaging including bi-exponential fitting for the detection of recurrent or residual tumour after (chemo)radiotherapy for laryngeal and hypopharyngeal cancers</title><author>Tshering Vogel, Dechen W. ; Zbaeren, Peter ; Geretschlaeger, Andreas ; Vermathen, Peter ; De Keyzer, Frederik ; Thoeny, Harriet C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-4828a0e96cb4d92533e63126f58c21d098348f27585649c59408a13c928eab6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biopsy</topic><topic>Biopsy, Needle</topic><topic>Cancer therapies</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Chemoradiotherapy - methods</topic><topic>Cohort Studies</topic><topic>Diagnostic Radiology</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>Edema</topic><topic>Female</topic><topic>Head and Neck</topic><topic>Head and Neck Neoplasms - diagnosis</topic><topic>Head and Neck Neoplasms - mortality</topic><topic>Head and Neck Neoplasms - therapy</topic><topic>Humans</topic><topic>Hypopharyngeal Neoplasms - diagnosis</topic><topic>Hypopharyngeal Neoplasms - mortality</topic><topic>Hypopharyngeal Neoplasms - therapy</topic><topic>Imaging</topic><topic>Immunohistochemistry</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Laryngeal Neoplasms - diagnosis</topic><topic>Laryngeal Neoplasms - mortality</topic><topic>Laryngeal Neoplasms - therapy</topic><topic>Laryngoscopy</topic><topic>Larynx</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - diagnosis</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm, Residual - diagnosis</topic><topic>Neoplasm, Residual - mortality</topic><topic>Neoplasm, Residual - pathology</topic><topic>Neuroradiology</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Quality of life</topic><topic>Quantitative analysis</topic><topic>Radiation therapy</topic><topic>Radiology</topic><topic>Risk Assessment</topic><topic>ROC Curve</topic><topic>Squamous Cell Carcinoma of Head and Neck</topic><topic>Statistics, Nonparametric</topic><topic>Surgery</topic><topic>Survival Rate</topic><topic>Tumors</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tshering Vogel, Dechen W.</creatorcontrib><creatorcontrib>Zbaeren, Peter</creatorcontrib><creatorcontrib>Geretschlaeger, Andreas</creatorcontrib><creatorcontrib>Vermathen, Peter</creatorcontrib><creatorcontrib>De Keyzer, Frederik</creatorcontrib><creatorcontrib>Thoeny, Harriet C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tshering Vogel, Dechen W.</au><au>Zbaeren, Peter</au><au>Geretschlaeger, Andreas</au><au>Vermathen, Peter</au><au>De Keyzer, Frederik</au><au>Thoeny, Harriet C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diffusion-weighted MR imaging including bi-exponential fitting for the detection of recurrent or residual tumour after (chemo)radiotherapy for laryngeal and hypopharyngeal cancers</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>23</volume><issue>2</issue><spage>562</spage><epage>569</epage><pages>562-569</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objectives
To assess whether diffusion-weighted magnetic resonance imaging (DW-MRI) including bi-exponential fitting helps to detect residual/recurrent tumours after (chemo)radiotherapy of laryngeal and hypopharyngeal carcinoma.
Methods
Forty-six patients with newly-developed/worsening symptoms after (chemo)radiotherapy for laryngeal/hypopharyngeal cancers were prospectively imaged using conventional MRI and axial DW-MRI. Qualitative (visual assessment) and quantitative analysis (mono-exponentially: total apparent diffusion coefficient [ADC
T
], and bi-exponentially: perfusion fraction [F
P
] and true diffusion coefficient [ADC
D
]) were performed. Diffusion parameters of tumour versus post-therapeutic changes were compared, with final diagnosis based on histopathology and follow-up. Mann-Whitney
U
test was used for statistical analysis.
Results
Qualitative DW-MRI combined with morphological images allowed the detection of tumour with a sensitivity of 94% and specificity 100%. ADC
T
and ADC
D
values were lower in tumour with values 120 ± 49 × 10
−5
mm
2
/s and 113 ± 50 × 10
−5
mm
2
/s, respectively, compared with post-therapeutic changes with values 182 ± 41 × 10
−5
mm
2
/s (
P
< 0.0002) and 160 ± 47 × 10
−5
mm
2
/s (
P
< 0.003), respectively. F
P
values were significantly lower in tumours than in non-tumours (13 ± 9% versus 31 ± 16%,
P
< 0.0002), with F
P
being the best quantitative parameter for differentiation between post-therapeutic changes and recurrence.
Conclusions
DW-MRI in combination with conventional MRI substantially improves detection and exclusion of tumour in patients with laryngeal and hypopharyngeal cancers after treatment with (chemo)radiotherapy on both qualitative and quantitative analysis, with F
P
being the best quantitative parameter in this context.
Key Points
•
DW-MRI is increasingly used to detect tumour recurrence.
•
DW-MRI allows accurate post-treatment recurrence detection in laryngeal or hypopharyngeal cancer
•
ADC values in recurrent tumour are lower than in benign tissue alterations
•
Both qualitative and quantitative DW-MRI approaches allow detection of recurrence
•
DW-MRI can easily be added to daily clinical routine imaging</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22865270</pmid><doi>10.1007/s00330-012-2596-x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0938-7994 |
| ispartof | European radiology, 2013-02, Vol.23 (2), p.562-569 |
| issn | 0938-7994 1432-1084 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1273737412 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Aged, 80 and over Biopsy Biopsy, Needle Cancer therapies Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - therapy Chemoradiotherapy - methods Cohort Studies Diagnostic Radiology Diffusion Magnetic Resonance Imaging - methods Edema Female Head and Neck Head and Neck Neoplasms - diagnosis Head and Neck Neoplasms - mortality Head and Neck Neoplasms - therapy Humans Hypopharyngeal Neoplasms - diagnosis Hypopharyngeal Neoplasms - mortality Hypopharyngeal Neoplasms - therapy Imaging Immunohistochemistry Internal Medicine Interventional Radiology Laryngeal Neoplasms - diagnosis Laryngeal Neoplasms - mortality Laryngeal Neoplasms - therapy Laryngoscopy Larynx Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medicine Medicine & Public Health Middle Aged Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Neoplasm, Residual - diagnosis Neoplasm, Residual - mortality Neoplasm, Residual - pathology Neuroradiology Patients Prognosis Prospective Studies Quality of life Quantitative analysis Radiation therapy Radiology Risk Assessment ROC Curve Squamous Cell Carcinoma of Head and Neck Statistics, Nonparametric Surgery Survival Rate Tumors Ultrasound |
| title | Diffusion-weighted MR imaging including bi-exponential fitting for the detection of recurrent or residual tumour after (chemo)radiotherapy for laryngeal and hypopharyngeal cancers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T21%3A18%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Diffusion-weighted%20MR%20imaging%20including%20bi-exponential%20fitting%20for%20the%20detection%20of%20recurrent%20or%20residual%20tumour%20after%20(chemo)radiotherapy%20for%20laryngeal%20and%20hypopharyngeal%20cancers&rft.jtitle=European%20radiology&rft.au=Tshering%20Vogel,%20Dechen%20W.&rft.date=2013-02-01&rft.volume=23&rft.issue=2&rft.spage=562&rft.epage=569&rft.pages=562-569&rft.issn=0938-7994&rft.eissn=1432-1084&rft_id=info:doi/10.1007/s00330-012-2596-x&rft_dat=%3Cproquest_cross%3E2867761101%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1270340270&rft_id=info:pmid/22865270&rfr_iscdi=true |