Asthma severity, polymorphisms in 20p13 and their interaction with tobacco smoke exposure

Background We investigated the association between genetic variation in chromosomal region 20p13‐p12 (ADAM33 and flanking genes ATRN, GFRA4, SIGLEC1 and HSPA12B) and asthma. Amongst asthmatics, we then investigated the association between genetic variants and asthma severity. We evaluated the effect...

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Veröffentlicht in:	Pediatric allergy and immunology 2013-02, Vol.24 (1), p.10-18
Hauptverfasser:	Bukvic, Blazenka Kljaic, Blekic, Mario, Simpson, Angela, Marinho, Susana, Curtin, John A., Hankinson, Jenny, Aberle, Neda, Custovic, Adnan
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - genetics ADAM33 Adolescent Asthma Asthma - genetics Asthma - physiopathology asthma severity Biological and medical sciences Case-Control Studies Child Child, Preschool children chromosome 20p13 Chromosomes, Human, Pair 20 - genetics Chronic obstructive pulmonary disease, asthma Environmental Exposure environmental tobacco smoke exposure Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gene-Environment Interaction General aspects Genetic diversity gene–environment interactions Humans Male Medical sciences Pneumology Polymorphism Polymorphism, Single Nucleotide - genetics Respiratory Function Tests Risk Factors Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Severity of Illness Index Smoking - genetics Tobacco smoke Tobacco Smoke Pollution - adverse effects
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