Fascin-1 expression in canine cutaneous and oral melanocytic tumours
Fascin‐1 expression was examined in 9 cutaneous melanocytomas and 47 oral melanomas. The cases were scored on the basis of extent and intensity of staining, and combined scores were calculated. Fascin‐1 expression was observed in 5/9 (56%) melanocytomas and 46/47 (98%) melanomas. The combined score...
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| Veröffentlicht in: | Veterinary & comparative oncology 2012-12, Vol.10 (4), p.303-311 |
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| creator | Yamada, N. Mori, T. Murakami, M. Noguchi, S. Sakai, H. Akao, Y. Maruo, K. |
| description | Fascin‐1 expression was examined in 9 cutaneous melanocytomas and 47 oral melanomas. The cases were scored on the basis of extent and intensity of staining, and combined scores were calculated. Fascin‐1 expression was observed in 5/9 (56%) melanocytomas and 46/47 (98%) melanomas. The combined score for fascin‐1 was significantly greater in stage III/IV melanomas than in stage I/II melanomas (P < 0.05). In addition, strong fascin‐1 staining was associated with a significantly shortened survival time (P < 0.05). The results of this study suggest that fascin‐1 overexpression correlates with the malignancy of canine melanoma and has the potential to be a new immunohistochemical marker to predict the clinical course of canine melanoma. In addition, targeted therapy for fascin‐1 may represent a new strategy for the treatment of canine melanoma. |
| doi_str_mv | 10.1111/j.1476-5829.2011.00300.x |
| format | Article |
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The cases were scored on the basis of extent and intensity of staining, and combined scores were calculated. Fascin‐1 expression was observed in 5/9 (56%) melanocytomas and 46/47 (98%) melanomas. The combined score for fascin‐1 was significantly greater in stage III/IV melanomas than in stage I/II melanomas (P < 0.05). In addition, strong fascin‐1 staining was associated with a significantly shortened survival time (P < 0.05). The results of this study suggest that fascin‐1 overexpression correlates with the malignancy of canine melanoma and has the potential to be a new immunohistochemical marker to predict the clinical course of canine melanoma. 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The cases were scored on the basis of extent and intensity of staining, and combined scores were calculated. Fascin‐1 expression was observed in 5/9 (56%) melanocytomas and 46/47 (98%) melanomas. The combined score for fascin‐1 was significantly greater in stage III/IV melanomas than in stage I/II melanomas (P < 0.05). In addition, strong fascin‐1 staining was associated with a significantly shortened survival time (P < 0.05). The results of this study suggest that fascin‐1 overexpression correlates with the malignancy of canine melanoma and has the potential to be a new immunohistochemical marker to predict the clinical course of canine melanoma. In addition, targeted therapy for fascin‐1 may represent a new strategy for the treatment of canine melanoma.</description><subject>Animals</subject><subject>Biomarkers, Tumor</subject><subject>canine</subject><subject>Dog Diseases - metabolism</subject><subject>Dogs</subject><subject>fascin-1</subject><subject>Gene Expression Regulation, Neoplastic - physiology</subject><subject>immunohistochemistry</subject><subject>invasion</subject><subject>melanoma</subject><subject>Melanoma - classification</subject><subject>Melanoma - metabolism</subject><subject>Melanoma - veterinary</subject><subject>metastasis</subject><subject>Microfilament Proteins - genetics</subject><subject>Microfilament Proteins - metabolism</subject><subject>Mouth Neoplasms - metabolism</subject><subject>Mouth Neoplasms - veterinary</subject><subject>Retrospective Studies</subject><subject>Skin Neoplasms - metabolism</subject><subject>Skin Neoplasms - veterinary</subject><issn>1476-5810</issn><issn>1476-5829</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtLxDAQx4Movr-C5OilNY-2acGLrO4qLAq-byGbTiBrH2vSYvfb21rt2bnMQP6_yfBDCFMS0r4u1iGNRBLEKctCRigNCeGEhN0OOpwedqeZkgN05P2aEMYizvbRAWOMJzyOD9H1XHltq4Bi6DYOvLd1hW2FtapsBVi3jaqgbj1WVY5rpwpcQqGqWm8bq3HTlnXr_AnaM6rwcPrbj9HL_OZ5dhssHxZ3s6tloCOSkECkeQ5pBswYmqlMGx1xbYigRGd5YiJDU9CG5bBKI5YJkUVJriFe8QS4UILxY3Q-7t24-rMF38jSeg1FMd4oKRNckFjQqI-mY1S72nsHRm6cLZXbSkrk4FCu5aBHDqrk4FD-OJRdj579_tKuSsgn8E9aH7gcA1-2gO2_F8vX2UM_9Hgw4tY30E24ch8y6e-P5dv9Qr49PT49zx9n8p1_A9kfj1U</recordid><startdate>201212</startdate><enddate>201212</enddate><creator>Yamada, N.</creator><creator>Mori, T.</creator><creator>Murakami, M.</creator><creator>Noguchi, S.</creator><creator>Sakai, H.</creator><creator>Akao, Y.</creator><creator>Maruo, K.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201212</creationdate><title>Fascin-1 expression in canine cutaneous and oral melanocytic tumours</title><author>Yamada, N. ; Mori, T. ; Murakami, M. ; Noguchi, S. ; Sakai, H. ; Akao, Y. ; Maruo, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4060-78dde89e2ff19a9cfc43cf0710c9d6f4f18ecf2deb842977946dce5b36e37a723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Biomarkers, Tumor</topic><topic>canine</topic><topic>Dog Diseases - metabolism</topic><topic>Dogs</topic><topic>fascin-1</topic><topic>Gene Expression Regulation, Neoplastic - physiology</topic><topic>immunohistochemistry</topic><topic>invasion</topic><topic>melanoma</topic><topic>Melanoma - classification</topic><topic>Melanoma - metabolism</topic><topic>Melanoma - veterinary</topic><topic>metastasis</topic><topic>Microfilament Proteins - genetics</topic><topic>Microfilament Proteins - metabolism</topic><topic>Mouth Neoplasms - metabolism</topic><topic>Mouth Neoplasms - veterinary</topic><topic>Retrospective Studies</topic><topic>Skin Neoplasms - metabolism</topic><topic>Skin Neoplasms - veterinary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamada, N.</creatorcontrib><creatorcontrib>Mori, T.</creatorcontrib><creatorcontrib>Murakami, M.</creatorcontrib><creatorcontrib>Noguchi, S.</creatorcontrib><creatorcontrib>Sakai, H.</creatorcontrib><creatorcontrib>Akao, Y.</creatorcontrib><creatorcontrib>Maruo, K.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary & comparative oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamada, N.</au><au>Mori, T.</au><au>Murakami, M.</au><au>Noguchi, S.</au><au>Sakai, H.</au><au>Akao, Y.</au><au>Maruo, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fascin-1 expression in canine cutaneous and oral melanocytic tumours</atitle><jtitle>Veterinary & comparative oncology</jtitle><addtitle>Vet Comp Oncol</addtitle><date>2012-12</date><risdate>2012</risdate><volume>10</volume><issue>4</issue><spage>303</spage><epage>311</epage><pages>303-311</pages><issn>1476-5810</issn><eissn>1476-5829</eissn><abstract>Fascin‐1 expression was examined in 9 cutaneous melanocytomas and 47 oral melanomas. The cases were scored on the basis of extent and intensity of staining, and combined scores were calculated. Fascin‐1 expression was observed in 5/9 (56%) melanocytomas and 46/47 (98%) melanomas. The combined score for fascin‐1 was significantly greater in stage III/IV melanomas than in stage I/II melanomas (P < 0.05). In addition, strong fascin‐1 staining was associated with a significantly shortened survival time (P < 0.05). The results of this study suggest that fascin‐1 overexpression correlates with the malignancy of canine melanoma and has the potential to be a new immunohistochemical marker to predict the clinical course of canine melanoma. In addition, targeted therapy for fascin‐1 may represent a new strategy for the treatment of canine melanoma.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22236355</pmid><doi>10.1111/j.1476-5829.2011.00300.x</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Biomarkers, Tumor canine Dog Diseases - metabolism Dogs fascin-1 Gene Expression Regulation, Neoplastic - physiology immunohistochemistry invasion melanoma Melanoma - classification Melanoma - metabolism Melanoma - veterinary metastasis Microfilament Proteins - genetics Microfilament Proteins - metabolism Mouth Neoplasms - metabolism Mouth Neoplasms - veterinary Retrospective Studies Skin Neoplasms - metabolism Skin Neoplasms - veterinary |
| title | Fascin-1 expression in canine cutaneous and oral melanocytic tumours |
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