Do SNPs of DRD4 gene predict adult persistence of ADHD in a Chinese sample?
Abstract The dopamine D4 receptor (DRD4) gene has been frequently studied in relation to attention deficit hyperactivity disorder (ADHD) but little is known about the contribution of single nucleotide polymorphisms (SNPs) of the DRD4 gene to the development and persistence of ADHD. In the present st...
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| Veröffentlicht in: | Psychiatry research 2013-01, Vol.205 (1), p.143-150 |
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| creator | Li, Yueling Baker-Ericzen, Mary Ji, Ning Chang, Weili Guan, Lili Qian, Qiujin Zhang, Yujuan Faraone, Stephen V Wang, Yufeng |
| description | Abstract The dopamine D4 receptor (DRD4) gene has been frequently studied in relation to attention deficit hyperactivity disorder (ADHD) but little is known about the contribution of single nucleotide polymorphisms (SNPs) of the DRD4 gene to the development and persistence of ADHD. In the present study, we examined the association between two SNPs in DRD4 (rs1800955, rs916455) and adult ADHD persistence in a Chinese sample. Subjects ( n =193) were diagnosed with ADHD in childhood and reassessed in young adulthood at an affiliated clinic of Peking University Sixth Hospital. Kaplan-Meier survival analyses and Cox proportional hazard models were used to test the association between ADHD remission and alleles of the two SNPs. DRD4 rs916455 C allele carriers were more likely to have persistent ADHD symptoms in adulthood. No significant association was found between rs1800955 allele and the course of ADHD. These newly detected associations between DRD4 polymorphisms and ADHD prognosis in adulthood may help to predict the persistence of childhood ADHD into adulthood. |
| doi_str_mv | 10.1016/j.psychres.2012.08.016 |
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In the present study, we examined the association between two SNPs in DRD4 (rs1800955, rs916455) and adult ADHD persistence in a Chinese sample. Subjects ( n =193) were diagnosed with ADHD in childhood and reassessed in young adulthood at an affiliated clinic of Peking University Sixth Hospital. Kaplan-Meier survival analyses and Cox proportional hazard models were used to test the association between ADHD remission and alleles of the two SNPs. DRD4 rs916455 C allele carriers were more likely to have persistent ADHD symptoms in adulthood. No significant association was found between rs1800955 allele and the course of ADHD. These newly detected associations between DRD4 polymorphisms and ADHD prognosis in adulthood may help to predict the persistence of childhood ADHD into adulthood.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/j.psychres.2012.08.016</identifier><identifier>PMID: 23031802</identifier><identifier>CODEN: PSRSDR</identifier><language>eng</language><publisher>Kidlington: Elsevier Ireland Ltd</publisher><subject>Adolescent ; Adult ADHD ; Asian Continental Ancestry Group - genetics ; Asian Continental Ancestry Group - psychology ; Attention Deficit Disorder with Hyperactivity - ethnology ; Attention Deficit Disorder with Hyperactivity - genetics ; Attention deficit disorders. Hyperactivity ; Attention-deficit/hyperactivity disorder (ADHD) ; Biological and medical sciences ; Child ; Child clinical studies ; Disease Progression ; Dopamine D4 receptor (DRD4) ; Female ; Gene Frequency ; Han Chinese ; Humans ; Kaplan-Meier Estimate ; Longitudinal ; Longitudinal Studies ; Male ; Medical sciences ; Polymorphism, Single Nucleotide ; Prognosis ; Proportional Hazards Models ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Receptors, Dopamine D4 - genetics ; Young Adult</subject><ispartof>Psychiatry research, 2013-01, Vol.205 (1), p.143-150</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2012 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-8bc497df6da7c1de9009305d349a7c7f1bea4e68da5ae2ce46b3b2473de601603</citedby><cites>FETCH-LOGICAL-c453t-8bc497df6da7c1de9009305d349a7c7f1bea4e68da5ae2ce46b3b2473de601603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.psychres.2012.08.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26850673$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23031802$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Yueling</creatorcontrib><creatorcontrib>Baker-Ericzen, Mary</creatorcontrib><creatorcontrib>Ji, Ning</creatorcontrib><creatorcontrib>Chang, Weili</creatorcontrib><creatorcontrib>Guan, Lili</creatorcontrib><creatorcontrib>Qian, Qiujin</creatorcontrib><creatorcontrib>Zhang, Yujuan</creatorcontrib><creatorcontrib>Faraone, Stephen V</creatorcontrib><creatorcontrib>Wang, Yufeng</creatorcontrib><title>Do SNPs of DRD4 gene predict adult persistence of ADHD in a Chinese sample?</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>Abstract The dopamine D4 receptor (DRD4) gene has been frequently studied in relation to attention deficit hyperactivity disorder (ADHD) but little is known about the contribution of single nucleotide polymorphisms (SNPs) of the DRD4 gene to the development and persistence of ADHD. In the present study, we examined the association between two SNPs in DRD4 (rs1800955, rs916455) and adult ADHD persistence in a Chinese sample. Subjects ( n =193) were diagnosed with ADHD in childhood and reassessed in young adulthood at an affiliated clinic of Peking University Sixth Hospital. Kaplan-Meier survival analyses and Cox proportional hazard models were used to test the association between ADHD remission and alleles of the two SNPs. DRD4 rs916455 C allele carriers were more likely to have persistent ADHD symptoms in adulthood. No significant association was found between rs1800955 allele and the course of ADHD. These newly detected associations between DRD4 polymorphisms and ADHD prognosis in adulthood may help to predict the persistence of childhood ADHD into adulthood.</description><subject>Adolescent</subject><subject>Adult ADHD</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Asian Continental Ancestry Group - psychology</subject><subject>Attention Deficit Disorder with Hyperactivity - ethnology</subject><subject>Attention Deficit Disorder with Hyperactivity - genetics</subject><subject>Attention deficit disorders. Hyperactivity</subject><subject>Attention-deficit/hyperactivity disorder (ADHD)</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child clinical studies</subject><subject>Disease Progression</subject><subject>Dopamine D4 receptor (DRD4)</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Han Chinese</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Longitudinal</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Receptors, Dopamine D4 - genetics</subject><subject>Young Adult</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhiMEokvhL1S-IHFJGH8kdi5AtQGKqABROFuOPaFesklqJ0j773G0W5C4cLL06pkZzzNZdkGhoECrl7tiigd7GzAWDCgrQBUpfpBtqJIsl5Txh9kmJWVOpaJn2ZMYdwDAaF0_zs4YB04VsE32sRnJzacvkYwdab42gvzAAckU0Hk7E-OWfiYThujjjIPFFbtsrhriB2LI9tYPGJFEs596fP00e9SZPuKz03uefX_39tv2Kr_-_P7D9vI6t6Lkc65aK2rpusoZaanDGqDmUDou6hTIjrZoBFbKmdIgsyiqlrdMSO6wShsBP89eHPtOYbxbMM5676PFvjcDjkvUlEkuQQCohFZH1IYxxoCdnoLfm3DQFPQqUu_0vUi9itSgdIpT4cVpxtLu0f0puzeXgOcnwERr-i6Ywfr4l6tUCZXkiXtz5DAZ-eUx6Gj9qtL5gHbWbvT__8urf1rY3g8-Tf2JB4y7cQlD8q2pjqlG36xnX69OGYAQqua_AdzIp10</recordid><startdate>20130130</startdate><enddate>20130130</enddate><creator>Li, Yueling</creator><creator>Baker-Ericzen, Mary</creator><creator>Ji, Ning</creator><creator>Chang, Weili</creator><creator>Guan, Lili</creator><creator>Qian, Qiujin</creator><creator>Zhang, Yujuan</creator><creator>Faraone, Stephen V</creator><creator>Wang, Yufeng</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130130</creationdate><title>Do SNPs of DRD4 gene predict adult persistence of ADHD in a Chinese sample?</title><author>Li, Yueling ; Baker-Ericzen, Mary ; Ji, Ning ; Chang, Weili ; Guan, Lili ; Qian, Qiujin ; Zhang, Yujuan ; Faraone, Stephen V ; Wang, Yufeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-8bc497df6da7c1de9009305d349a7c7f1bea4e68da5ae2ce46b3b2473de601603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult ADHD</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Asian Continental Ancestry Group - psychology</topic><topic>Attention Deficit Disorder with Hyperactivity - ethnology</topic><topic>Attention Deficit Disorder with Hyperactivity - genetics</topic><topic>Attention deficit disorders. Hyperactivity</topic><topic>Attention-deficit/hyperactivity disorder (ADHD)</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child clinical studies</topic><topic>Disease Progression</topic><topic>Dopamine D4 receptor (DRD4)</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Han Chinese</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Longitudinal</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Receptors, Dopamine D4 - genetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Yueling</creatorcontrib><creatorcontrib>Baker-Ericzen, Mary</creatorcontrib><creatorcontrib>Ji, Ning</creatorcontrib><creatorcontrib>Chang, Weili</creatorcontrib><creatorcontrib>Guan, Lili</creatorcontrib><creatorcontrib>Qian, Qiujin</creatorcontrib><creatorcontrib>Zhang, Yujuan</creatorcontrib><creatorcontrib>Faraone, Stephen V</creatorcontrib><creatorcontrib>Wang, Yufeng</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yueling</au><au>Baker-Ericzen, Mary</au><au>Ji, Ning</au><au>Chang, Weili</au><au>Guan, Lili</au><au>Qian, Qiujin</au><au>Zhang, Yujuan</au><au>Faraone, Stephen V</au><au>Wang, Yufeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Do SNPs of DRD4 gene predict adult persistence of ADHD in a Chinese sample?</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>2013-01-30</date><risdate>2013</risdate><volume>205</volume><issue>1</issue><spage>143</spage><epage>150</epage><pages>143-150</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><coden>PSRSDR</coden><abstract>Abstract The dopamine D4 receptor (DRD4) gene has been frequently studied in relation to attention deficit hyperactivity disorder (ADHD) but little is known about the contribution of single nucleotide polymorphisms (SNPs) of the DRD4 gene to the development and persistence of ADHD. In the present study, we examined the association between two SNPs in DRD4 (rs1800955, rs916455) and adult ADHD persistence in a Chinese sample. Subjects ( n =193) were diagnosed with ADHD in childhood and reassessed in young adulthood at an affiliated clinic of Peking University Sixth Hospital. Kaplan-Meier survival analyses and Cox proportional hazard models were used to test the association between ADHD remission and alleles of the two SNPs. DRD4 rs916455 C allele carriers were more likely to have persistent ADHD symptoms in adulthood. No significant association was found between rs1800955 allele and the course of ADHD. These newly detected associations between DRD4 polymorphisms and ADHD prognosis in adulthood may help to predict the persistence of childhood ADHD into adulthood.</abstract><cop>Kidlington</cop><pub>Elsevier Ireland Ltd</pub><pmid>23031802</pmid><doi>10.1016/j.psychres.2012.08.016</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Adult ADHD Asian Continental Ancestry Group - genetics Asian Continental Ancestry Group - psychology Attention Deficit Disorder with Hyperactivity - ethnology Attention Deficit Disorder with Hyperactivity - genetics Attention deficit disorders. Hyperactivity Attention-deficit/hyperactivity disorder (ADHD) Biological and medical sciences Child Child clinical studies Disease Progression Dopamine D4 receptor (DRD4) Female Gene Frequency Han Chinese Humans Kaplan-Meier Estimate Longitudinal Longitudinal Studies Male Medical sciences Polymorphism, Single Nucleotide Prognosis Proportional Hazards Models Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, Dopamine D4 - genetics Young Adult |
| title | Do SNPs of DRD4 gene predict adult persistence of ADHD in a Chinese sample? |
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