Effects of dexamethasone and pheniramine hydrogen maleate on stress response in patients undergoing elective laparoscopic cholecystectomy
Abstract Background Laparoscopic cholecystectomy (LC) still leads to significant postoperative nausea and vomiting (PONV) and pain. Our aim was to evaluate the efficacy of dexamethasone or pheniramine hydrogen maleate, either alone or combined, in reducing the stress response and symptoms after LC....
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| creator | Karaman, Kerem, M.D Bostanci, Erdal Birol, M.D Aksoy, Erol, M.D Ulas, Murat, M.D Yigit, Tuba, M.D Erdemli, Mehmet Ozcan, M.D Ercin, Ugur, M.D Bilgihan, Ayse, M.D Saydam, Gul, M.D Akoglu, Musa, M.D |
| description | Abstract Background Laparoscopic cholecystectomy (LC) still leads to significant postoperative nausea and vomiting (PONV) and pain. Our aim was to evaluate the efficacy of dexamethasone or pheniramine hydrogen maleate, either alone or combined, in reducing the stress response and symptoms after LC. Methods Patients were randomly assigned to 1 of 4 groups, each consisting of 20 patients: control, dexamethasone (8 mg/2 mL), pheniramine hydrogen maleate (45.5 mg/2 mL), and the combined group. The drugs were given before anesthesia induction. Results C-reactive protein levels (CRP) and visual analog scale (VAS) scores were significantly less in the dexamethasone ( P = .003) and combined groups ( P < .001). Both dexamethasone ( P < .001) and pheniramine hydrogen maleate ( P = .005) significantly reduced PONV. Conclusions Dexamethasone significantly reduced postoperative pain and the systemic acute-phase response, whereas these effects were only partially attained with pheniramine hydrogen maleate. Both dexamethasone and pheniramine hydrogen maleate significantly reduced PONV. An additive effect seemed to occur if these drugs were used in combination. |
| doi_str_mv | 10.1016/j.amjsurg.2012.05.010 |
| format | Article |
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Our aim was to evaluate the efficacy of dexamethasone or pheniramine hydrogen maleate, either alone or combined, in reducing the stress response and symptoms after LC. Methods Patients were randomly assigned to 1 of 4 groups, each consisting of 20 patients: control, dexamethasone (8 mg/2 mL), pheniramine hydrogen maleate (45.5 mg/2 mL), and the combined group. The drugs were given before anesthesia induction. Results C-reactive protein levels (CRP) and visual analog scale (VAS) scores were significantly less in the dexamethasone ( P = .003) and combined groups ( P < .001). Both dexamethasone ( P < .001) and pheniramine hydrogen maleate ( P = .005) significantly reduced PONV. Conclusions Dexamethasone significantly reduced postoperative pain and the systemic acute-phase response, whereas these effects were only partially attained with pheniramine hydrogen maleate. Both dexamethasone and pheniramine hydrogen maleate significantly reduced PONV. An additive effect seemed to occur if these drugs were used in combination.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2012.05.010</identifier><identifier>PMID: 22944391</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject><![CDATA[Adult ; Aged ; Analgesics ; Analgesics - administration & dosage ; Analgesics - therapeutic use ; Anesthesia ; Antiemetics - administration & dosage ; Antiemetics - therapeutic use ; Blood ; C-Reactive Protein - metabolism ; Cholecystectomy, Laparoscopic ; Cytokines ; Dexamethasone ; Dexamethasone - administration & dosage ; Dexamethasone - therapeutic use ; Drug Administration Schedule ; Drug dosages ; Drug Synergism ; Drug Therapy, Combination ; Elective Surgical Procedures ; Female ; Hospitals, Teaching ; Humans ; Laparoscopic cholecystectomy ; Male ; Middle Aged ; Pain Measurement ; Pain, Postoperative - etiology ; Pain, Postoperative - prevention & control ; Pheniramine - administration & dosage ; Pheniramine - therapeutic use ; Pheniramine hydrogen maleate ; Postoperative Nausea and Vomiting - etiology ; Postoperative Nausea and Vomiting - prevention & control ; Postoperative period ; Prospective Studies ; Stress response ; Stress, Physiological - drug effects ; Studies ; Surgery ; Treatment Outcome ; Turkey]]></subject><ispartof>The American journal of surgery, 2013-02, Vol.205 (2), p.213-219</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-c6f27f764c6fbff56e512173b0b247fa749a44e10fe742945fdbb25ab4a81a8e3</citedby><cites>FETCH-LOGICAL-c448t-c6f27f764c6fbff56e512173b0b247fa749a44e10fe742945fdbb25ab4a81a8e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S000296101200414X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22944391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karaman, Kerem, M.D</creatorcontrib><creatorcontrib>Bostanci, Erdal Birol, M.D</creatorcontrib><creatorcontrib>Aksoy, Erol, M.D</creatorcontrib><creatorcontrib>Ulas, Murat, M.D</creatorcontrib><creatorcontrib>Yigit, Tuba, M.D</creatorcontrib><creatorcontrib>Erdemli, Mehmet Ozcan, M.D</creatorcontrib><creatorcontrib>Ercin, Ugur, M.D</creatorcontrib><creatorcontrib>Bilgihan, Ayse, M.D</creatorcontrib><creatorcontrib>Saydam, Gul, M.D</creatorcontrib><creatorcontrib>Akoglu, Musa, M.D</creatorcontrib><title>Effects of dexamethasone and pheniramine hydrogen maleate on stress response in patients undergoing elective laparoscopic cholecystectomy</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Abstract Background Laparoscopic cholecystectomy (LC) still leads to significant postoperative nausea and vomiting (PONV) and pain. Our aim was to evaluate the efficacy of dexamethasone or pheniramine hydrogen maleate, either alone or combined, in reducing the stress response and symptoms after LC. Methods Patients were randomly assigned to 1 of 4 groups, each consisting of 20 patients: control, dexamethasone (8 mg/2 mL), pheniramine hydrogen maleate (45.5 mg/2 mL), and the combined group. The drugs were given before anesthesia induction. Results C-reactive protein levels (CRP) and visual analog scale (VAS) scores were significantly less in the dexamethasone ( P = .003) and combined groups ( P < .001). Both dexamethasone ( P < .001) and pheniramine hydrogen maleate ( P = .005) significantly reduced PONV. Conclusions Dexamethasone significantly reduced postoperative pain and the systemic acute-phase response, whereas these effects were only partially attained with pheniramine hydrogen maleate. Both dexamethasone and pheniramine hydrogen maleate significantly reduced PONV. An additive effect seemed to occur if these drugs were used in combination.</description><subject>Adult</subject><subject>Aged</subject><subject>Analgesics</subject><subject>Analgesics - administration & dosage</subject><subject>Analgesics - therapeutic use</subject><subject>Anesthesia</subject><subject>Antiemetics - administration & dosage</subject><subject>Antiemetics - therapeutic use</subject><subject>Blood</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cholecystectomy, Laparoscopic</subject><subject>Cytokines</subject><subject>Dexamethasone</subject><subject>Dexamethasone - administration & dosage</subject><subject>Dexamethasone - therapeutic use</subject><subject>Drug Administration Schedule</subject><subject>Drug dosages</subject><subject>Drug Synergism</subject><subject>Drug Therapy, Combination</subject><subject>Elective Surgical Procedures</subject><subject>Female</subject><subject>Hospitals, Teaching</subject><subject>Humans</subject><subject>Laparoscopic cholecystectomy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pain Measurement</subject><subject>Pain, Postoperative - etiology</subject><subject>Pain, Postoperative - prevention & control</subject><subject>Pheniramine - administration & dosage</subject><subject>Pheniramine - therapeutic use</subject><subject>Pheniramine hydrogen maleate</subject><subject>Postoperative Nausea and Vomiting - etiology</subject><subject>Postoperative Nausea and Vomiting - prevention & control</subject><subject>Postoperative period</subject><subject>Prospective Studies</subject><subject>Stress response</subject><subject>Stress, Physiological - drug effects</subject><subject>Studies</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Turkey</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFUsuO1DAQtBCIHRY-AWSJC5cE23FeF9BqtTyklTgAEjfLcdozDokd7GRFPoG_pkczgLQXLrbbrqp2dzUhzznLOePV6yHX05DWuM8F4yJnZc44e0B2vKnbjDdN8ZDsGGMiayvOLsiTlAYMOZfFY3IhRCtl0fId-XVjLZgl0WBpDz_1BMtBp-CBat_T-QDeRT05jA9bH8MePJ30CHoBGjxNS4SUKC5z8Amo83TWiwOPgqvvIe6D83sKI6Zwd0BHPesYkgmzM9QcAt5vacHHMG1PySOrxwTPzvsl-fru5sv1h-z20_uP11e3mZGyWTJTWVHbupJ46KwtKyi54HXRsU7I2upatlpK4MxCLbHM0vZdJ0rdSd1w3UBxSV6ddOcYfqyQFjW5ZGActYewJsVFXVRtWRcSoS_vQYewRo-_Q1RTVW3LRImo8oQyWFqKYNUc3aTjpjhTR6_UoM5eqaNXipUKvULei7P62k3Q_2X9MQcBb08AwHbcOYgqGeytgd5F7Jnqg_tvijf3FMzovDN6_A4bpH_VqIQc9fk4MMd54YIxyeW34jewCMCE</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Karaman, Kerem, M.D</creator><creator>Bostanci, Erdal Birol, M.D</creator><creator>Aksoy, Erol, M.D</creator><creator>Ulas, Murat, M.D</creator><creator>Yigit, Tuba, M.D</creator><creator>Erdemli, Mehmet Ozcan, M.D</creator><creator>Ercin, Ugur, M.D</creator><creator>Bilgihan, Ayse, M.D</creator><creator>Saydam, Gul, M.D</creator><creator>Akoglu, Musa, M.D</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20130201</creationdate><title>Effects of dexamethasone and pheniramine hydrogen maleate on stress response in patients undergoing elective laparoscopic cholecystectomy</title><author>Karaman, Kerem, M.D ; Bostanci, Erdal Birol, M.D ; Aksoy, Erol, M.D ; Ulas, Murat, M.D ; Yigit, Tuba, M.D ; Erdemli, Mehmet Ozcan, M.D ; Ercin, Ugur, M.D ; Bilgihan, Ayse, M.D ; Saydam, Gul, M.D ; Akoglu, Musa, M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-c6f27f764c6fbff56e512173b0b247fa749a44e10fe742945fdbb25ab4a81a8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analgesics</topic><topic>Analgesics - administration & dosage</topic><topic>Analgesics - therapeutic use</topic><topic>Anesthesia</topic><topic>Antiemetics - administration & dosage</topic><topic>Antiemetics - therapeutic use</topic><topic>Blood</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cholecystectomy, Laparoscopic</topic><topic>Cytokines</topic><topic>Dexamethasone</topic><topic>Dexamethasone - administration & dosage</topic><topic>Dexamethasone - therapeutic use</topic><topic>Drug Administration Schedule</topic><topic>Drug dosages</topic><topic>Drug Synergism</topic><topic>Drug Therapy, Combination</topic><topic>Elective Surgical Procedures</topic><topic>Female</topic><topic>Hospitals, Teaching</topic><topic>Humans</topic><topic>Laparoscopic cholecystectomy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pain Measurement</topic><topic>Pain, Postoperative - etiology</topic><topic>Pain, Postoperative - prevention & control</topic><topic>Pheniramine - administration & dosage</topic><topic>Pheniramine - therapeutic use</topic><topic>Pheniramine hydrogen maleate</topic><topic>Postoperative Nausea and Vomiting - etiology</topic><topic>Postoperative Nausea and Vomiting - prevention & control</topic><topic>Postoperative period</topic><topic>Prospective Studies</topic><topic>Stress response</topic><topic>Stress, Physiological - drug effects</topic><topic>Studies</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><topic>Turkey</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karaman, Kerem, M.D</creatorcontrib><creatorcontrib>Bostanci, Erdal Birol, M.D</creatorcontrib><creatorcontrib>Aksoy, Erol, M.D</creatorcontrib><creatorcontrib>Ulas, Murat, M.D</creatorcontrib><creatorcontrib>Yigit, Tuba, M.D</creatorcontrib><creatorcontrib>Erdemli, Mehmet Ozcan, M.D</creatorcontrib><creatorcontrib>Ercin, Ugur, M.D</creatorcontrib><creatorcontrib>Bilgihan, Ayse, M.D</creatorcontrib><creatorcontrib>Saydam, Gul, M.D</creatorcontrib><creatorcontrib>Akoglu, Musa, M.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karaman, Kerem, M.D</au><au>Bostanci, Erdal Birol, M.D</au><au>Aksoy, Erol, M.D</au><au>Ulas, Murat, M.D</au><au>Yigit, Tuba, M.D</au><au>Erdemli, Mehmet Ozcan, M.D</au><au>Ercin, Ugur, M.D</au><au>Bilgihan, Ayse, M.D</au><au>Saydam, Gul, M.D</au><au>Akoglu, Musa, M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of dexamethasone and pheniramine hydrogen maleate on stress response in patients undergoing elective laparoscopic cholecystectomy</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>205</volume><issue>2</issue><spage>213</spage><epage>219</epage><pages>213-219</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><abstract>Abstract Background Laparoscopic cholecystectomy (LC) still leads to significant postoperative nausea and vomiting (PONV) and pain. Our aim was to evaluate the efficacy of dexamethasone or pheniramine hydrogen maleate, either alone or combined, in reducing the stress response and symptoms after LC. Methods Patients were randomly assigned to 1 of 4 groups, each consisting of 20 patients: control, dexamethasone (8 mg/2 mL), pheniramine hydrogen maleate (45.5 mg/2 mL), and the combined group. The drugs were given before anesthesia induction. Results C-reactive protein levels (CRP) and visual analog scale (VAS) scores were significantly less in the dexamethasone ( P = .003) and combined groups ( P < .001). Both dexamethasone ( P < .001) and pheniramine hydrogen maleate ( P = .005) significantly reduced PONV. Conclusions Dexamethasone significantly reduced postoperative pain and the systemic acute-phase response, whereas these effects were only partially attained with pheniramine hydrogen maleate. Both dexamethasone and pheniramine hydrogen maleate significantly reduced PONV. An additive effect seemed to occur if these drugs were used in combination.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>22944391</pmid><doi>10.1016/j.amjsurg.2012.05.010</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Analgesics Analgesics - administration & dosage Analgesics - therapeutic use Anesthesia Antiemetics - administration & dosage Antiemetics - therapeutic use Blood C-Reactive Protein - metabolism Cholecystectomy, Laparoscopic Cytokines Dexamethasone Dexamethasone - administration & dosage Dexamethasone - therapeutic use Drug Administration Schedule Drug dosages Drug Synergism Drug Therapy, Combination Elective Surgical Procedures Female Hospitals, Teaching Humans Laparoscopic cholecystectomy Male Middle Aged Pain Measurement Pain, Postoperative - etiology Pain, Postoperative - prevention & control Pheniramine - administration & dosage Pheniramine - therapeutic use Pheniramine hydrogen maleate Postoperative Nausea and Vomiting - etiology Postoperative Nausea and Vomiting - prevention & control Postoperative period Prospective Studies Stress response Stress, Physiological - drug effects Studies Surgery Treatment Outcome Turkey |
| title | Effects of dexamethasone and pheniramine hydrogen maleate on stress response in patients undergoing elective laparoscopic cholecystectomy |
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