p53 can repress transcription of cell cycle genes through a p21(WAF1/CIP1)-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements

The tumor suppressor p53 plays an important role in cell cycle arrest by downregulating transcription. Many genes repressed by p53 code for proteins with functions in G₂/M. A large portion of these genes is controlled by cell cycle-dependent elements (CDE) and cell cycle genes homology regions (CHR)...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2012-12, Vol.11 (24), p.4661-4672
Hauptverfasser:	Quaas, Marianne, Müller, Gerd A, Engeland, Kurt
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle - drug effects Cell Cycle - genetics Cyclin B2 - genetics Cyclin B2 - metabolism Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Doxorubicin - pharmacology HCT116 Cells Humans Kv Channel-Interacting Proteins - genetics Kv Channel-Interacting Proteins - metabolism Mice NIH 3T3 Cells Protein Binding - drug effects Protein Binding - genetics Repressor Proteins - genetics Repressor Proteins - metabolism Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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