Metabolism and pharmacokinetics of 3-n-butylphthalide (NBP) in humans: the role of cytochrome P450s and alcohol dehydrogenase in biotransformation

3-n-Butylphthalide (NBP) is a cardiovascular drug currently used for the treatment of cerebral ischemia. The present study aims to investigate the metabolism, pharmacokinetics, and excretion of NBP in humans and identify the enzymes responsible for the formation of major metabolites. NBP underwent e...

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Veröffentlicht in:	Drug metabolism and disposition 2013-02, Vol.41 (2), p.430-444
Hauptverfasser:	Diao, Xingxing, Deng, Pan, Xie, Cen, Li, Xiuli, Zhong, Dafang, Zhang, Yifan, Chen, Xiaoyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Alcohol Dehydrogenase - metabolism Animals Benzofurans - administration & dosage Benzofurans - blood Benzofurans - chemistry Benzofurans - pharmacokinetics Benzofurans - urine Biotransformation Cardiovascular Agents - administration & dosage Cardiovascular Agents - blood Cardiovascular Agents - chemistry Cardiovascular Agents - pharmacokinetics Cardiovascular Agents - urine Chromatography, Liquid Cunninghamella - metabolism Cytochrome P-450 Enzyme System - metabolism Humans Hydroxylation Intestinal Absorption Isoenzymes Kidney - metabolism Liver - enzymology Male Metabolomics - methods Molecular Structure Oxidation-Reduction Rats Rats, Sprague-Dawley Spectrometry, Mass, Electrospray Ionization Substrate Specificity Young Adult
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