Chromosome Instability Modulated by BMI1―AURKA Signaling Drives Progression in Head and Neck Cancer

Chromosomal instability (CIN) is widely considered a hallmark of cancer, but its precise roles in cancer stem cells (CSC) and malignant progression remain uncertain. BMI1 is a member of the Polycomb group of chromatin-modifier proteins that is essential for stem cell self-renewal. In human cancers,...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2013-01, Vol.73 (2), p.953-966
Hauptverfasser:	CHOU, Chun-Hung, YANG, Neng-Kai, LIU, Ting-Yun, TAI, Shyh-Kuan, HSU, Dennis Shin-Shian, CHEN, Ya-Wei, CHEN, Yann-Jang, CHANG, Cheng-Chi, TZENG, Cheng-Hwai, YANG, Muh-Hwa
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Aurora Kinase A Aurora Kinases beta Catenin - metabolism Biological and medical sciences Cell Line, Tumor Chromosomal Instability Disease Progression Enzyme Activation Head and Neck Neoplasms - genetics Head and Neck Neoplasms - pathology Humans Medical sciences Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Pharmacology. Drug treatments Polycomb Repressive Complex 1 - metabolism Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Signal Transduction Tumors
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