Interleukin-33 Drives a Proinflammatory Endothelial Activation That Selectively Targets Nonquiescent Cells

OBJECTIVE—Interleukin (IL)-33 is a nuclear protein that is released from stressed or damaged cells to act as an alarmin. We investigated the effects of IL-33 on endothelial cells, using the prototype IL-1 family member, IL-1β, as a reference. METHODS AND RESULTS—Human umbilical vein endothelial cell...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2013-02, Vol.33 (2), p.e47-e55
Hauptverfasser:	Pollheimer, Jürgen, Bodin, Johanna, Sundnes, Olav, Edelmann, Reidunn J, Skånland, Sigrid S, Sponheim, Jon, Brox, Mari Johanna, Sundlisæter, Eirik, Loos, Tamara, Vatn, Morten, Kasprzycka, Monika, Wang, Junbai, Küchler, Axel M, Taskén, Kjetil, Haraldsen, Guttorm, Hol, Johanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals Biopsy Cell Proliferation Cells, Cultured Cellular Senescence Cyclin-Dependent Kinase Inhibitor p27 - metabolism Dermatitis - immunology Dermatitis - pathology E-Selectin - metabolism Endothelial Cells - immunology Endothelial Cells - pathology Female Flow Cytometry Genetic Vectors Human Umbilical Vein Endothelial Cells - immunology Humans Inflammation Mediators - metabolism Interleukin-1beta - metabolism Interleukin-33 Interleukins - genetics Interleukins - metabolism JNK Mitogen-Activated Protein Kinases - metabolism Mice Mice, Inbred C57BL Neovascularization, Physiologic NF-kappa B - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Receptors, Interleukin - metabolism Retinoblastoma Protein - metabolism RNA Interference Signal Transduction Skin - blood supply Transcription, Genetic Transduction, Genetic Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!