Bone Morphogenetic Protein-4 Mediates Cardiac Hypertrophy, Apoptosis, and Fibrosis in Experimentally Pathological Cardiac Hypertrophy

Identifying the key factor mediating pathological cardiac hypertrophy is critically important for developing the strategy to protect against heart failure. Bone morphogenetic protein-4 (BMP4) is a mechanosensitive and proinflammatory gene. In this study, we investigated the role of BMP4 in cardiac h...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2013-02, Vol.61 (2), p.352-360
Hauptverfasser:	Sun, Bo, Huo, Rong, Sheng, Yue, Li, Yue, Xie, Xin, Chen, Chang, Liu, Hui-Bin, Li, Na, Li, Cheng-Bo, Guo, Wen-Ting, Zhu, Jiu-Xin, Yang, Bao-Feng, Dong, De-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - toxicity Animals Apoptosis - physiology Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Bone Morphogenetic Protein 4 - blood Bone Morphogenetic Protein 4 - metabolism Cardiology. Vascular system Cardiomegaly - chemically induced Cardiomegaly - metabolism Cardiomegaly - pathology Fibrosis - chemically induced Fibrosis - metabolism Fibrosis - pathology Heart Heart Failure - blood Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans Medical sciences Mice Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Physical Conditioning, Animal - physiology Reactive Oxygen Species - metabolism
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