Loss of Epidermal Growth Factor Receptor in Vascular Smooth Muscle Cells and Cardiomyocytes Causes Arterial Hypotension and Cardiac Hypertrophy

The epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, contributes to parainflammatory dysregulation, possibly causing cardiovascular dysfunction and remodeling. The physiological role of cardiovascular EGFR is not completely understood. To investigate the physiological importance...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2013-02, Vol.61 (2), p.333-340
Hauptverfasser:	Schreier, Barbara, Rabe, Sindy, Schneider, Bettina, Bretschneider, Maria, Rupp, Sebastian, Ruhs, Stefanie, Neumann, Joachim, Rueckschloss, Uwe, Sibilia, Maria, Gotthardt, Michael, Grossmann, Claudia, Gekle, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - physiology Blood vessels and receptors Cardiac Output - physiology Cardiology. Vascular system Cardiomegaly - genetics Cardiomegaly - metabolism Cardiomegaly - physiopathology Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Fundamental and applied biological sciences. Psychology Hypotension - genetics Hypotension - metabolism Hypotension - physiopathology Medical sciences Mice Mice, Knockout Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - physiopathology Myocytes, Cardiac - metabolism Myocytes, Smooth Muscle - metabolism Reactive Oxygen Species - metabolism Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Vertebrates: cardiovascular system
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