Intraoperative Electron Beam Radiotherapy for Primary Treatment of Stage IIB Cervical Cancer: A Retrospective Study
Objective: A retrospective study to evaluate intraoperative electron beam radiotherapy (IOERT) as a primary treatment modality for stage IIB cervical squamous cell carcinoma. Methods: Patients underwent treatment with IOERT (n = 78) or radical radiotherapy (RT; n = 89). Patients in the IOERT group r...
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| Veröffentlicht in: | Journal of international medical research 2012-12, Vol.40 (6), p.2346-2354 |
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| creator | Liu, Z Gao, Y Soong, Yl Chen, X Gao, F Luo, W Sheng, W Ren, J Zhang, L Wang, J |
| description | Objective:
A retrospective study to evaluate intraoperative electron beam radiotherapy (IOERT) as a primary treatment modality for stage IIB cervical squamous cell carcinoma.
Methods:
Patients underwent treatment with IOERT (n = 78) or radical radiotherapy (RT; n = 89). Patients in the IOERT group received 20 Gy external beam radiotherapy (EBRT) in 10 fractions, intracavitary brachy -therapy (7 - 14 Gy, in patients with tumours ≥ 4 cm in diameter) and simple hysterectomy/selective lymphadenectomy with 18 - 20 Gy IOERT. Patients in the RT group received 50 Gy EBRT in 25 fractions followed by intracavitary brachytherapy (35 - 40 Gy).
Results:
Median duration of follow-up was 92 months. IOERT resulted in significantly better 5- and 10-year overall survival, disease-free survival and local control rates, as well as fewer rectal and bladder complications, compared with RT.
Conclusion:
IOERT is an effective primary treatment for stage IIB cervical squamous cell carcinoma. |
| doi_str_mv | 10.1177/030006051204000633 |
| format | Article |
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A retrospective study to evaluate intraoperative electron beam radiotherapy (IOERT) as a primary treatment modality for stage IIB cervical squamous cell carcinoma.
Methods:
Patients underwent treatment with IOERT (n = 78) or radical radiotherapy (RT; n = 89). Patients in the IOERT group received 20 Gy external beam radiotherapy (EBRT) in 10 fractions, intracavitary brachy -therapy (7 - 14 Gy, in patients with tumours ≥ 4 cm in diameter) and simple hysterectomy/selective lymphadenectomy with 18 - 20 Gy IOERT. Patients in the RT group received 50 Gy EBRT in 25 fractions followed by intracavitary brachytherapy (35 - 40 Gy).
Results:
Median duration of follow-up was 92 months. IOERT resulted in significantly better 5- and 10-year overall survival, disease-free survival and local control rates, as well as fewer rectal and bladder complications, compared with RT.
Conclusion:
IOERT is an effective primary treatment for stage IIB cervical squamous cell carcinoma.</description><identifier>ISSN: 0300-0605</identifier><identifier>EISSN: 1473-2300</identifier><identifier>DOI: 10.1177/030006051204000633</identifier><identifier>PMID: 23321192</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Aged ; Brachytherapy - adverse effects ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - radiotherapy ; Carcinoma, Squamous Cell - surgery ; Combined Modality Therapy ; Disease-Free Survival ; Female ; Humans ; Hysterectomy - adverse effects ; Intraoperative Period ; Lymph Node Excision ; Middle Aged ; Neoplasm Staging ; Radiotherapy Dosage ; Retrospective Studies ; Uterine Cervical Neoplasms - mortality ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - radiotherapy ; Uterine Cervical Neoplasms - surgery ; Young Adult</subject><ispartof>Journal of international medical research, 2012-12, Vol.40 (6), p.2346-2354</ispartof><rights>2012 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2533-2682ea78176a183fee96f2022e7ae1b02845344ba23499769e682ee7eb338ed33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/030006051204000633$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/030006051204000633$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,860,21945,27830,27901,27902,44921,45309</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/030006051204000633?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23321192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Z</creatorcontrib><creatorcontrib>Gao, Y</creatorcontrib><creatorcontrib>Soong, Yl</creatorcontrib><creatorcontrib>Chen, X</creatorcontrib><creatorcontrib>Gao, F</creatorcontrib><creatorcontrib>Luo, W</creatorcontrib><creatorcontrib>Sheng, W</creatorcontrib><creatorcontrib>Ren, J</creatorcontrib><creatorcontrib>Zhang, L</creatorcontrib><creatorcontrib>Wang, J</creatorcontrib><title>Intraoperative Electron Beam Radiotherapy for Primary Treatment of Stage IIB Cervical Cancer: A Retrospective Study</title><title>Journal of international medical research</title><addtitle>J Int Med Res</addtitle><description>Objective:
A retrospective study to evaluate intraoperative electron beam radiotherapy (IOERT) as a primary treatment modality for stage IIB cervical squamous cell carcinoma.
Methods:
Patients underwent treatment with IOERT (n = 78) or radical radiotherapy (RT; n = 89). Patients in the IOERT group received 20 Gy external beam radiotherapy (EBRT) in 10 fractions, intracavitary brachy -therapy (7 - 14 Gy, in patients with tumours ≥ 4 cm in diameter) and simple hysterectomy/selective lymphadenectomy with 18 - 20 Gy IOERT. Patients in the RT group received 50 Gy EBRT in 25 fractions followed by intracavitary brachytherapy (35 - 40 Gy).
Results:
Median duration of follow-up was 92 months. IOERT resulted in significantly better 5- and 10-year overall survival, disease-free survival and local control rates, as well as fewer rectal and bladder complications, compared with RT.
Conclusion:
IOERT is an effective primary treatment for stage IIB cervical squamous cell carcinoma.</description><subject>Adult</subject><subject>Aged</subject><subject>Brachytherapy - adverse effects</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Combined Modality Therapy</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Hysterectomy - adverse effects</subject><subject>Intraoperative Period</subject><subject>Lymph Node Excision</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Radiotherapy Dosage</subject><subject>Retrospective Studies</subject><subject>Uterine Cervical Neoplasms - mortality</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterine Cervical Neoplasms - radiotherapy</subject><subject>Uterine Cervical Neoplasms - surgery</subject><subject>Young Adult</subject><issn>0300-0605</issn><issn>1473-2300</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AURQdRbK3-ARcySzex85FkEndtqBooKG1dh0nyoin5cmZS6L93QqobwdU8eOcd5l6Ebil5oFSIOeGEEJ94lBF3mDg_Q1PqCu4wuzlH0wFwBmKCrrTeE-Iy32OXaMI4Z5SGbIp03Bgl2w6UNOUB8KqCzKi2wUuQNd7IvGzNp112R1y0Cr-pspbqiHcKpKmhMbgt8NbID8BxvMQRqEOZyQpHsslAPeIF3oDV6c5aB_3W9PnxGl0UstJwc3pn6P1ptYtenPXrcxwt1k7GPG5D-AEDKQIqfEkDXgCEfsEIYyAk0JSwwPW466aScTcMhR_CcAACUs4DyDmfofvR26n2qwdtkrrUGVSVbKDtdUKZ4F4QEjewKBvRzH5WKyiSbkyaUJIMZSd_y7ZHdyd_n9aQ_578tGuB-QhoW1Cyb3vV2Lz_Kb8Bj-CF8A</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Liu, Z</creator><creator>Gao, Y</creator><creator>Soong, Yl</creator><creator>Chen, X</creator><creator>Gao, F</creator><creator>Luo, W</creator><creator>Sheng, W</creator><creator>Ren, J</creator><creator>Zhang, L</creator><creator>Wang, J</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121201</creationdate><title>Intraoperative Electron Beam Radiotherapy for Primary Treatment of Stage IIB Cervical Cancer: A Retrospective Study</title><author>Liu, Z ; Gao, Y ; Soong, Yl ; Chen, X ; Gao, F ; Luo, W ; Sheng, W ; Ren, J ; Zhang, L ; Wang, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2533-2682ea78176a183fee96f2022e7ae1b02845344ba23499769e682ee7eb338ed33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Brachytherapy - adverse effects</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Combined Modality Therapy</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Hysterectomy - adverse effects</topic><topic>Intraoperative Period</topic><topic>Lymph Node Excision</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Radiotherapy Dosage</topic><topic>Retrospective Studies</topic><topic>Uterine Cervical Neoplasms - mortality</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Uterine Cervical Neoplasms - radiotherapy</topic><topic>Uterine Cervical Neoplasms - surgery</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Z</creatorcontrib><creatorcontrib>Gao, Y</creatorcontrib><creatorcontrib>Soong, Yl</creatorcontrib><creatorcontrib>Chen, X</creatorcontrib><creatorcontrib>Gao, F</creatorcontrib><creatorcontrib>Luo, W</creatorcontrib><creatorcontrib>Sheng, W</creatorcontrib><creatorcontrib>Ren, J</creatorcontrib><creatorcontrib>Zhang, L</creatorcontrib><creatorcontrib>Wang, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of international medical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Liu, Z</au><au>Gao, Y</au><au>Soong, Yl</au><au>Chen, X</au><au>Gao, F</au><au>Luo, W</au><au>Sheng, W</au><au>Ren, J</au><au>Zhang, L</au><au>Wang, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intraoperative Electron Beam Radiotherapy for Primary Treatment of Stage IIB Cervical Cancer: A Retrospective Study</atitle><jtitle>Journal of international medical research</jtitle><addtitle>J Int Med Res</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>40</volume><issue>6</issue><spage>2346</spage><epage>2354</epage><pages>2346-2354</pages><issn>0300-0605</issn><eissn>1473-2300</eissn><abstract>Objective:
A retrospective study to evaluate intraoperative electron beam radiotherapy (IOERT) as a primary treatment modality for stage IIB cervical squamous cell carcinoma.
Methods:
Patients underwent treatment with IOERT (n = 78) or radical radiotherapy (RT; n = 89). Patients in the IOERT group received 20 Gy external beam radiotherapy (EBRT) in 10 fractions, intracavitary brachy -therapy (7 - 14 Gy, in patients with tumours ≥ 4 cm in diameter) and simple hysterectomy/selective lymphadenectomy with 18 - 20 Gy IOERT. Patients in the RT group received 50 Gy EBRT in 25 fractions followed by intracavitary brachytherapy (35 - 40 Gy).
Results:
Median duration of follow-up was 92 months. IOERT resulted in significantly better 5- and 10-year overall survival, disease-free survival and local control rates, as well as fewer rectal and bladder complications, compared with RT.
Conclusion:
IOERT is an effective primary treatment for stage IIB cervical squamous cell carcinoma.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>23321192</pmid><doi>10.1177/030006051204000633</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Adult Aged Brachytherapy - adverse effects Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - radiotherapy Carcinoma, Squamous Cell - surgery Combined Modality Therapy Disease-Free Survival Female Humans Hysterectomy - adverse effects Intraoperative Period Lymph Node Excision Middle Aged Neoplasm Staging Radiotherapy Dosage Retrospective Studies Uterine Cervical Neoplasms - mortality Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - radiotherapy Uterine Cervical Neoplasms - surgery Young Adult |
| title | Intraoperative Electron Beam Radiotherapy for Primary Treatment of Stage IIB Cervical Cancer: A Retrospective Study |
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