Genomic cloning and promoter functional analysis of myostatin-2 in shi drum, Umbrina cirrosa: Conservation of muscle-specific promoter activity

Myostatin (MSTN) is a member of the transforming growth factor-ß superfamily, known as a negative regulator of skeletal muscle development and growth in mammals. In contrast to mammals, fish possess at least two paralogs of MSTN: MSTN-1 and MSTN-2. Here we describe the cloning and sequence analysis...

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Veröffentlicht in:	Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 2013-02, Vol.164 (2), p.99-110
Hauptverfasser:	Nadjar-Boger, Elisabeth, Maccatrozzo, Lisa, Radaelli, Giuseppe, Funkenstein, Bruria
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Flanking Region - genetics Alternative Splicing Amino Acid Sequence amino acid sequences Animals Base Sequence binding sites Binding Sites - genetics Brain C2 cells CHO Cells Cloning, Molecular Conserved Sequence - genetics Cricetinae Cricetulus exons Fish Proteins - classification Fish Proteins - genetics Gene Expression genes growth and development introns marine fish Molecular Sequence Data muscle development muscles Muscles - cytology Muscles - metabolism myocytes myostatin Myostatin - classification Myostatin - genetics Myostatin-2 PC12 cells Perciformes - genetics Phylogeny promoter regions Promoter Regions, Genetic - genetics Promoter transcriptional activity Protein Isoforms - genetics Protein Precursors - genetics Regulatory Sequences, Nucleic Acid - genetics Reporter gene Reverse Transcriptase Polymerase Chain Reaction sequence analysis Sequence Analysis, DNA Sequence Homology, Amino Acid skeletal muscle Sparus aurata Spliced and unspliced transcripts transcription (genetics) transcription factors transfection Umbrina cirrosa
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