New approach to improve encapsulation and antitumor activity of doxorubicin loaded in solid lipid nanoparticles

This work aimed to develop solid lipid nanoparticles (SLNs) loaded with doxorubicin evaluating the influence of docosahexaenoic acid (DHA), a polyunsaturated fatty acid that enhances the activity of anticancer drugs, on drug encapsulation efficiency (EE). The SLN were characterized for size, zeta po...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2013-01, Vol.48 (1-2), p.282-290
Hauptverfasser:	Mussi, Samuel Vidal, Silva, Renata Carvalho, Oliveira, Mônica Cristina de, Lucci, Carolina Madeira, Azevedo, Ricardo Bentes de, Ferreira, Lucas Antônio Miranda
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Octanol - chemistry Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - chemistry Cancer Cell Line, Tumor Cell Survival - drug effects Docosahexaenoic acid Docosahexaenoic Acids - chemistry Doxorubicin Doxorubicin - administration & dosage Doxorubicin - chemistry Drug Carriers - administration & dosage Drug Carriers - chemistry Humans Ion pairing Microscopy, Electron, Transmission Nanoparticles - administration & dosage Nanoparticles - chemistry Nanoparticles - ultrastructure Particle Size Solid lipid nanoparticles Water - chemistry
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