Anti‐LFA‐1 or rapamycin overcome costimulation blockade‐resistant rejection in sensitized bone marrow recipients

Summary While costimulation blockade‐based mixed chimerism protocols work well for inducing tolerance in rodents, translation to preclinical large animal/nonhuman primate models has been less successful. One recognized cause for these difficulties is the high frequency of alloreactive memory T cells...

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Veröffentlicht in:	Transplant international 2013-02, Vol.26 (2), p.206-218
Hauptverfasser:	Ramsey, Haley, Pilat, Nina, Hock, Karin, Klaus, Christoph, Unger, Lukas, Schwarz, Christoph, Baranyi, Ulrike, Gattringer, Martina, Schwaiger, Elisabeth, Wrba, Fritz, Wekerle, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - metabolism Antibodies, Monoclonal - therapeutic use anti‐LFA‐1 Bone Marrow Cells - cytology Bone Marrow Transplantation CD40 Ligand - metabolism Chimerism costimulation blockade CTLA-4 Antigen - metabolism Enzyme-Linked Immunosorbent Assay Flow Cytometry Graft Rejection Interferon-gamma - metabolism Lymphocyte Function-Associated Antigen-1 - immunology Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL mixed chimerism rapamycin Sirolimus - therapeutic use Skin Transplantation T memory cells T-Lymphocytes - cytology tolerance Transplantation Tolerance
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