A case study of real-time monitoring of solid-state phase transformations in acoustically levitated particles using near infrared and Raman spectroscopy

The objective of this study was to monitor the amorphous-to-crystalline solid-state phase transformation kinetics of the model drug ibuprofen with spectroscopic methods during acoustic levitation. Chemical and physical information was obtained by real-time near infrared (NIRS) and Raman spectroscopy...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2013-01, Vol.48 (1-2), p.97-103
Hauptverfasser:	Rehder, Sönke, Wu, Jian X., Laackmann, Julian, Moritz, Hans-Ulrich, Rantanen, Jukka, Rades, Thomas, Leopold, Claudia S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic levitation Acoustics Anti-Inflammatory Agents, Non-Steroidal - chemistry Crystallisation kinetics Crystallization Ibuprofen - chemistry Models, Theoretical Multivariate curve resolution Near infrared spectroscopy Raman spectroscopy Spectroscopy, Near-Infrared Spectrum Analysis, Raman
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