TNF-α-induced CXCL8 production by A549 cells: Involvement of the non-neuronal cholinergic system

It was recently suggested that the non-neuronal cholinergic system has a regulatory role in pulmonary inflammation. We investigated this system's involvement in the control of cytokine production by the A549 human alveolar epithelial cell line. CXCL8 and acetylcholine (ACh) concentrations were...

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Veröffentlicht in:	Pharmacological research 2013-02, Vol.68 (1), p.16-23
Hauptverfasser:	Xu, Z.-P., Devillier, P., Xu, G.-N., Qi, H., Zhu, L., Zhou, W., Hou, L.-N., Tang, Y.-B., Yang, K., Yu, Z.-H., Chen, H.-Z., Cui, Y.-Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 cell Acetylcholine Acetylcholine - metabolism Cell Line, Tumor Cholinesterase Cholinesterase Inhibitors - pharmacology Humans Interleukin-8 (CXCL8) Interleukin-8 - metabolism Mitogen-Activated Protein Kinases - metabolism Muscarinic receptors NF-kappa B - metabolism Physostigmine - pharmacology Receptors, Muscarinic - genetics RNA, Messenger - metabolism Tumor necrosis factor-alpha (TNF-α) Tumor Necrosis Factor-alpha - pharmacology
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