Renal Dysfunction is Common Among Adults After Palliation for Previous Tetralogy of Fallot
Long-term survival after tetralogy of Fallot (TOF) repair is excellent. However, little is published regarding late noncardiac complications. This study aimed to determine the prevalence and risk factors for renal dysfunction among adults after TOF repair. For this study, 56 adult patients with comp...
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| Veröffentlicht in: | Pediatric cardiology 2013, Vol.34 (1), p.165-169 |
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| creator | Buelow, Matthew W. Dall, Aaron Bartz, Peter J. Tweddell, James S. Sowinski, Jane Rudd, Nancy Katzmark, Lindsey Earing, Michael G. |
| description | Long-term survival after tetralogy of Fallot (TOF) repair is excellent. However, little is published regarding late noncardiac complications. This study aimed to determine the prevalence and risk factors for renal dysfunction among adults after TOF repair. For this study, 56 adult patients with complete repair of TOF were identified, and their charts were retrospectively reviewed. An estimated glomerular filtration rate (eGFR) for each patient was calculated using the Modification of Diet in Renal Disease formula (MDRD). Using each patient’s eGFR, he or she was classified into stages based on the National Kidney Foundation chronic kidney disease (CKD) staging. Clinical parameters were compared among patients with and those without renal dysfunction to identify risk factors for renal impairment. The median estimated eGFR rate for the cohort was 78 ml/min/1.73 m
2
. Based on the National Kidney Foundation CKD staging system, 54 % of the patients had at least stage 2 chronic renal disease. The risk factors identified were hypertension (
p
|
| doi_str_mv | 10.1007/s00246-012-0408-3 |
| format | Article |
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2
. Based on the National Kidney Foundation CKD staging system, 54 % of the patients had at least stage 2 chronic renal disease. The risk factors identified were hypertension (
p
< 0.01), type 2 diabetes mellitus (
p
< 0.05), longer follow-up evaluation (
p
< 0.005), older age at complete repair (
p
< 0.05), and use of daily diuretics (
p
< 0.05). After repair of TOF, renal dysfunction is common at late follow-up evaluation. The study findings show the importance of routine assessment of renal function and the need to limit or avoid future episodes of acute kidney injury in this at-risk population.</description><identifier>ISSN: 0172-0643</identifier><identifier>EISSN: 1432-1971</identifier><identifier>DOI: 10.1007/s00246-012-0408-3</identifier><identifier>PMID: 22673967</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Adolescent ; Adult ; Adults ; Aged ; Cardiac Surgery ; Cardiology ; Chronic kidney failure ; Complications and side effects ; Diuretics ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Humans ; Hypertension ; Kidney - physiopathology ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Middle Aged ; Original Article ; Palliative Care ; Prevalence ; Renal Insufficiency, Chronic - diagnosis ; Renal Insufficiency, Chronic - physiopathology ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Tetralogy of Fallot ; Tetralogy of Fallot - surgery ; Type 2 diabetes ; Vascular Surgery ; Young Adult</subject><ispartof>Pediatric cardiology, 2013, Vol.34 (1), p.165-169</ispartof><rights>Springer Science+Business Media, LLC 2012</rights><rights>COPYRIGHT 2013 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-40320fb3e8f351f5dd254e1eba17756253e9fac5ad69e0f918125fcddbdab4b13</citedby><cites>FETCH-LOGICAL-c411t-40320fb3e8f351f5dd254e1eba17756253e9fac5ad69e0f918125fcddbdab4b13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00246-012-0408-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00246-012-0408-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22673967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buelow, Matthew W.</creatorcontrib><creatorcontrib>Dall, Aaron</creatorcontrib><creatorcontrib>Bartz, Peter J.</creatorcontrib><creatorcontrib>Tweddell, James S.</creatorcontrib><creatorcontrib>Sowinski, Jane</creatorcontrib><creatorcontrib>Rudd, Nancy</creatorcontrib><creatorcontrib>Katzmark, Lindsey</creatorcontrib><creatorcontrib>Earing, Michael G.</creatorcontrib><title>Renal Dysfunction is Common Among Adults After Palliation for Previous Tetralogy of Fallot</title><title>Pediatric cardiology</title><addtitle>Pediatr Cardiol</addtitle><addtitle>Pediatr Cardiol</addtitle><description>Long-term survival after tetralogy of Fallot (TOF) repair is excellent. However, little is published regarding late noncardiac complications. This study aimed to determine the prevalence and risk factors for renal dysfunction among adults after TOF repair. For this study, 56 adult patients with complete repair of TOF were identified, and their charts were retrospectively reviewed. An estimated glomerular filtration rate (eGFR) for each patient was calculated using the Modification of Diet in Renal Disease formula (MDRD). Using each patient’s eGFR, he or she was classified into stages based on the National Kidney Foundation chronic kidney disease (CKD) staging. Clinical parameters were compared among patients with and those without renal dysfunction to identify risk factors for renal impairment. The median estimated eGFR rate for the cohort was 78 ml/min/1.73 m
2
. Based on the National Kidney Foundation CKD staging system, 54 % of the patients had at least stage 2 chronic renal disease. The risk factors identified were hypertension (
p
< 0.01), type 2 diabetes mellitus (
p
< 0.05), longer follow-up evaluation (
p
< 0.005), older age at complete repair (
p
< 0.05), and use of daily diuretics (
p
< 0.05). After repair of TOF, renal dysfunction is common at late follow-up evaluation. The study findings show the importance of routine assessment of renal function and the need to limit or avoid future episodes of acute kidney injury in this at-risk population.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adults</subject><subject>Aged</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Chronic kidney failure</subject><subject>Complications and side effects</subject><subject>Diuretics</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Kidney - physiopathology</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Palliative Care</subject><subject>Prevalence</subject><subject>Renal Insufficiency, Chronic - diagnosis</subject><subject>Renal Insufficiency, Chronic - physiopathology</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Tetralogy of Fallot</subject><subject>Tetralogy of Fallot - surgery</subject><subject>Type 2 diabetes</subject><subject>Vascular Surgery</subject><subject>Young Adult</subject><issn>0172-0643</issn><issn>1432-1971</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2L1TAUhoMozp3RH-BGCm7cdMzJR9Muyx1HhQFFxo2bkDYnlwxpMybtwP335tpREEQC-TrPezjwEPIK6CVQqt5lSploagqspoK2NX9CdiA4q6FT8JTsKKhSaQQ_I-c531FKW9rK5-SMsUbxrlE78v0rziZUV8fs1nlcfJwrn6t9nKZy68t2qHq7hiVXvVswVV9MCN784lwsz4QPPq65usUlmRAPxyq66rpAcXlBnjkTMr58PC_It-v3t_uP9c3nD5_2_U09CoClFpQz6gaOreMSnLSWSYGAgwGlZMMkx86ZURrbdEhdBy0w6UZrB2sGMQC_IG-3vvcp_lgxL3ryecQQzIxlNA1McUlbJdqCvtnQgwmo_eximXo84bpXICXjIFWhLv9BlWVx8mOc0fny_1cAtsCYYs4Jnb5PfjLpqIHqkym9mdLFlD6Z0rxkXj9OvQ4T2j-J32oKwDYgl9J8wKTv4pqKrPyfrj8BCJmc8g</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Buelow, Matthew W.</creator><creator>Dall, Aaron</creator><creator>Bartz, Peter J.</creator><creator>Tweddell, James S.</creator><creator>Sowinski, Jane</creator><creator>Rudd, Nancy</creator><creator>Katzmark, Lindsey</creator><creator>Earing, Michael G.</creator><general>Springer-Verlag</general><general>Springer</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2013</creationdate><title>Renal Dysfunction is Common Among Adults After Palliation for Previous Tetralogy of Fallot</title><author>Buelow, Matthew W. ; Dall, Aaron ; Bartz, Peter J. ; Tweddell, James S. ; Sowinski, Jane ; Rudd, Nancy ; Katzmark, Lindsey ; Earing, Michael G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-40320fb3e8f351f5dd254e1eba17756253e9fac5ad69e0f918125fcddbdab4b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adults</topic><topic>Aged</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Chronic kidney failure</topic><topic>Complications and side effects</topic><topic>Diuretics</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Kidney - physiopathology</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Palliative Care</topic><topic>Prevalence</topic><topic>Renal Insufficiency, Chronic - diagnosis</topic><topic>Renal Insufficiency, Chronic - physiopathology</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Tetralogy of Fallot</topic><topic>Tetralogy of Fallot - surgery</topic><topic>Type 2 diabetes</topic><topic>Vascular Surgery</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buelow, Matthew W.</creatorcontrib><creatorcontrib>Dall, Aaron</creatorcontrib><creatorcontrib>Bartz, Peter J.</creatorcontrib><creatorcontrib>Tweddell, James S.</creatorcontrib><creatorcontrib>Sowinski, Jane</creatorcontrib><creatorcontrib>Rudd, Nancy</creatorcontrib><creatorcontrib>Katzmark, Lindsey</creatorcontrib><creatorcontrib>Earing, Michael G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buelow, Matthew W.</au><au>Dall, Aaron</au><au>Bartz, Peter J.</au><au>Tweddell, James S.</au><au>Sowinski, Jane</au><au>Rudd, Nancy</au><au>Katzmark, Lindsey</au><au>Earing, Michael G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal Dysfunction is Common Among Adults After Palliation for Previous Tetralogy of Fallot</atitle><jtitle>Pediatric cardiology</jtitle><stitle>Pediatr Cardiol</stitle><addtitle>Pediatr Cardiol</addtitle><date>2013</date><risdate>2013</risdate><volume>34</volume><issue>1</issue><spage>165</spage><epage>169</epage><pages>165-169</pages><issn>0172-0643</issn><eissn>1432-1971</eissn><abstract>Long-term survival after tetralogy of Fallot (TOF) repair is excellent. However, little is published regarding late noncardiac complications. This study aimed to determine the prevalence and risk factors for renal dysfunction among adults after TOF repair. For this study, 56 adult patients with complete repair of TOF were identified, and their charts were retrospectively reviewed. An estimated glomerular filtration rate (eGFR) for each patient was calculated using the Modification of Diet in Renal Disease formula (MDRD). Using each patient’s eGFR, he or she was classified into stages based on the National Kidney Foundation chronic kidney disease (CKD) staging. Clinical parameters were compared among patients with and those without renal dysfunction to identify risk factors for renal impairment. The median estimated eGFR rate for the cohort was 78 ml/min/1.73 m
2
. Based on the National Kidney Foundation CKD staging system, 54 % of the patients had at least stage 2 chronic renal disease. The risk factors identified were hypertension (
p
< 0.01), type 2 diabetes mellitus (
p
< 0.05), longer follow-up evaluation (
p
< 0.005), older age at complete repair (
p
< 0.05), and use of daily diuretics (
p
< 0.05). After repair of TOF, renal dysfunction is common at late follow-up evaluation. The study findings show the importance of routine assessment of renal function and the need to limit or avoid future episodes of acute kidney injury in this at-risk population.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>22673967</pmid><doi>10.1007/s00246-012-0408-3</doi><tpages>5</tpages></addata></record> |
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| ispartof | Pediatric cardiology, 2013, Vol.34 (1), p.165-169 |
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| subjects | Adolescent Adult Adults Aged Cardiac Surgery Cardiology Chronic kidney failure Complications and side effects Diuretics Female Follow-Up Studies Glomerular Filtration Rate Humans Hypertension Kidney - physiopathology Male Medical research Medicine Medicine & Public Health Medicine, Experimental Middle Aged Original Article Palliative Care Prevalence Renal Insufficiency, Chronic - diagnosis Renal Insufficiency, Chronic - physiopathology Retrospective Studies Risk Assessment Risk Factors Tetralogy of Fallot Tetralogy of Fallot - surgery Type 2 diabetes Vascular Surgery Young Adult |
| title | Renal Dysfunction is Common Among Adults After Palliation for Previous Tetralogy of Fallot |
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