Mechanisms of complement lectin pathway activation and resistance by trypanosomatid parasites
► The complement lectin pathway is rapidly activated by trypanosomes and Leishmania. ► The expression of stage-specific complement receptors confers resistance to lysis. ► The main mechanisms involves C3 convertase inhibition and shedding of C3b and MAC. ► Host genetic deficiency of the lectin pathw...
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| Veröffentlicht in: | Molecular immunology 2013-04, Vol.53 (4), p.328-334 |
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| creator | Cestari, Igor Evans-Osses, Ingrid Schlapbach, Luregn J. de Messias-Reason, Iara Ramirez, Marcel I. |
| description | ► The complement lectin pathway is rapidly activated by trypanosomes and Leishmania. ► The expression of stage-specific complement receptors confers resistance to lysis. ► The main mechanisms involves C3 convertase inhibition and shedding of C3b and MAC. ► Host genetic deficiency of the lectin pathway correlates to infection susceptibility. ► Disease progression is also aggravated by host deficiency of the lectin pathway.
Studies in the past decade have demonstrated a crucial role for the complement lectin pathway in host defence against protozoan microbes. Recognition of pathogen surface molecules by mannan-binding lectin and ficolins revealed new mechanisms of innate immune defence and a diversity of parasite strategies of immune evasion. In the present review, we will discuss the current knowledge of: (1) the molecular mechanism of lectin pathway activation by trypanosomes; (2) the mechanisms of complement evasion by trypanosomes; and (3) host genetic deficiencies of complement lectin pathway factors that contribute to infection susceptibility and disease progression. This review will focus on trypanosomatids, the parasites that cause Chagas disease, leishmaniasis and sleeping sickness (African trypanosomiasis). |
| doi_str_mv | 10.1016/j.molimm.2012.08.015 |
| format | Article |
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Studies in the past decade have demonstrated a crucial role for the complement lectin pathway in host defence against protozoan microbes. Recognition of pathogen surface molecules by mannan-binding lectin and ficolins revealed new mechanisms of innate immune defence and a diversity of parasite strategies of immune evasion. In the present review, we will discuss the current knowledge of: (1) the molecular mechanism of lectin pathway activation by trypanosomes; (2) the mechanisms of complement evasion by trypanosomes; and (3) host genetic deficiencies of complement lectin pathway factors that contribute to infection susceptibility and disease progression. This review will focus on trypanosomatids, the parasites that cause Chagas disease, leishmaniasis and sleeping sickness (African trypanosomiasis).</description><identifier>ISSN: 0161-5890</identifier><identifier>EISSN: 1872-9142</identifier><identifier>DOI: 10.1016/j.molimm.2012.08.015</identifier><identifier>PMID: 23063472</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Chagas disease ; Chagas Disease - genetics ; Chagas Disease - immunology ; Chagas Disease - metabolism ; Complement Pathway, Mannose-Binding Lectin - genetics ; Complement Pathway, Mannose-Binding Lectin - immunology ; Complement system ; Complement System Proteins - genetics ; Complement System Proteins - immunology ; Ficolins ; Gene Expression ; Host-Parasite Interactions ; Humans ; Immune Evasion ; Immunity, Innate ; Innate immunity ; Lectin pathway ; Lectins - genetics ; Lectins - immunology ; Mannose-Binding Lectin - genetics ; Mannose-Binding Lectin - immunology ; Parasite host cell interaction ; T. cruzi ; Trypanosoma - genetics ; Trypanosoma - immunology ; Trypanosomiasis ; Trypanosomiasis, African - genetics ; Trypanosomiasis, African - immunology ; Trypanosomiasis, African - metabolism ; Variant Surface Glycoproteins, Trypanosoma - genetics ; Variant Surface Glycoproteins, Trypanosoma - immunology</subject><ispartof>Molecular immunology, 2013-04, Vol.53 (4), p.328-334</ispartof><rights>2012 Elsevier Ltd</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-25ca5cca88387c3d50f46dc83fe5f41ff85f2fa626d685851a0a3b040871ee043</citedby><cites>FETCH-LOGICAL-c362t-25ca5cca88387c3d50f46dc83fe5f41ff85f2fa626d685851a0a3b040871ee043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.molimm.2012.08.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23063472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cestari, Igor</creatorcontrib><creatorcontrib>Evans-Osses, Ingrid</creatorcontrib><creatorcontrib>Schlapbach, Luregn J.</creatorcontrib><creatorcontrib>de Messias-Reason, Iara</creatorcontrib><creatorcontrib>Ramirez, Marcel I.</creatorcontrib><title>Mechanisms of complement lectin pathway activation and resistance by trypanosomatid parasites</title><title>Molecular immunology</title><addtitle>Mol Immunol</addtitle><description>► The complement lectin pathway is rapidly activated by trypanosomes and Leishmania. ► The expression of stage-specific complement receptors confers resistance to lysis. ► The main mechanisms involves C3 convertase inhibition and shedding of C3b and MAC. ► Host genetic deficiency of the lectin pathway correlates to infection susceptibility. ► Disease progression is also aggravated by host deficiency of the lectin pathway.
Studies in the past decade have demonstrated a crucial role for the complement lectin pathway in host defence against protozoan microbes. Recognition of pathogen surface molecules by mannan-binding lectin and ficolins revealed new mechanisms of innate immune defence and a diversity of parasite strategies of immune evasion. In the present review, we will discuss the current knowledge of: (1) the molecular mechanism of lectin pathway activation by trypanosomes; (2) the mechanisms of complement evasion by trypanosomes; and (3) host genetic deficiencies of complement lectin pathway factors that contribute to infection susceptibility and disease progression. This review will focus on trypanosomatids, the parasites that cause Chagas disease, leishmaniasis and sleeping sickness (African trypanosomiasis).</description><subject>Animals</subject><subject>Chagas disease</subject><subject>Chagas Disease - genetics</subject><subject>Chagas Disease - immunology</subject><subject>Chagas Disease - metabolism</subject><subject>Complement Pathway, Mannose-Binding Lectin - genetics</subject><subject>Complement Pathway, Mannose-Binding Lectin - immunology</subject><subject>Complement system</subject><subject>Complement System Proteins - genetics</subject><subject>Complement System Proteins - immunology</subject><subject>Ficolins</subject><subject>Gene Expression</subject><subject>Host-Parasite Interactions</subject><subject>Humans</subject><subject>Immune Evasion</subject><subject>Immunity, Innate</subject><subject>Innate immunity</subject><subject>Lectin pathway</subject><subject>Lectins - genetics</subject><subject>Lectins - immunology</subject><subject>Mannose-Binding Lectin - genetics</subject><subject>Mannose-Binding Lectin - immunology</subject><subject>Parasite host cell interaction</subject><subject>T. cruzi</subject><subject>Trypanosoma - genetics</subject><subject>Trypanosoma - immunology</subject><subject>Trypanosomiasis</subject><subject>Trypanosomiasis, African - genetics</subject><subject>Trypanosomiasis, African - immunology</subject><subject>Trypanosomiasis, African - metabolism</subject><subject>Variant Surface Glycoproteins, Trypanosoma - genetics</subject><subject>Variant Surface Glycoproteins, Trypanosoma - immunology</subject><issn>0161-5890</issn><issn>1872-9142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFq3DAQhkVJabZJ36AEHXuxO5IsWbkUSkjaQkov7TEIrTwiWizLkbQp-_ZR2LTHnIaB75-f-Qj5yKBnwNTnXR_THGLsOTDeg-6ByTdkw_TIu0s28BOyaRjrpL6EU_K-lB0AKFDyHTnlApQYRr4hdz_R3dsllFho8tSluM4Ycal0RlfDQldb7__aA7Vte7Q1pIXaZaIZSyjVLg7p9kBrPqx2SSXFRkwtk20JFcs5eevtXPDDyzwjf26uf199725_fftx9fW2c0Lx2nHprHTOai306MQkwQ9qclp4lH5g3mvpubeKq0lpqSWzYMUWBtAjQ4RBnJFPx7trTg97LNXEUBzOs10w7YthfBQSRjHohg5H1OVUSkZv1hyizQfDwDyLNTtzFGuexRrQpoltsYuXhv024vQ_9M9kA74cAWx_PgbMpriAzc8UcjNpphReb3gCHWONYw</recordid><startdate>201304</startdate><enddate>201304</enddate><creator>Cestari, Igor</creator><creator>Evans-Osses, Ingrid</creator><creator>Schlapbach, Luregn J.</creator><creator>de Messias-Reason, Iara</creator><creator>Ramirez, Marcel I.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201304</creationdate><title>Mechanisms of complement lectin pathway activation and resistance by trypanosomatid parasites</title><author>Cestari, Igor ; Evans-Osses, Ingrid ; Schlapbach, Luregn J. ; de Messias-Reason, Iara ; Ramirez, Marcel I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-25ca5cca88387c3d50f46dc83fe5f41ff85f2fa626d685851a0a3b040871ee043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Chagas disease</topic><topic>Chagas Disease - genetics</topic><topic>Chagas Disease - immunology</topic><topic>Chagas Disease - metabolism</topic><topic>Complement Pathway, Mannose-Binding Lectin - genetics</topic><topic>Complement Pathway, Mannose-Binding Lectin - immunology</topic><topic>Complement system</topic><topic>Complement System Proteins - genetics</topic><topic>Complement System Proteins - immunology</topic><topic>Ficolins</topic><topic>Gene Expression</topic><topic>Host-Parasite Interactions</topic><topic>Humans</topic><topic>Immune Evasion</topic><topic>Immunity, Innate</topic><topic>Innate immunity</topic><topic>Lectin pathway</topic><topic>Lectins - genetics</topic><topic>Lectins - immunology</topic><topic>Mannose-Binding Lectin - genetics</topic><topic>Mannose-Binding Lectin - immunology</topic><topic>Parasite host cell interaction</topic><topic>T. cruzi</topic><topic>Trypanosoma - genetics</topic><topic>Trypanosoma - immunology</topic><topic>Trypanosomiasis</topic><topic>Trypanosomiasis, African - genetics</topic><topic>Trypanosomiasis, African - immunology</topic><topic>Trypanosomiasis, African - metabolism</topic><topic>Variant Surface Glycoproteins, Trypanosoma - genetics</topic><topic>Variant Surface Glycoproteins, Trypanosoma - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cestari, Igor</creatorcontrib><creatorcontrib>Evans-Osses, Ingrid</creatorcontrib><creatorcontrib>Schlapbach, Luregn J.</creatorcontrib><creatorcontrib>de Messias-Reason, Iara</creatorcontrib><creatorcontrib>Ramirez, Marcel I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cestari, Igor</au><au>Evans-Osses, Ingrid</au><au>Schlapbach, Luregn J.</au><au>de Messias-Reason, Iara</au><au>Ramirez, Marcel I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanisms of complement lectin pathway activation and resistance by trypanosomatid parasites</atitle><jtitle>Molecular immunology</jtitle><addtitle>Mol Immunol</addtitle><date>2013-04</date><risdate>2013</risdate><volume>53</volume><issue>4</issue><spage>328</spage><epage>334</epage><pages>328-334</pages><issn>0161-5890</issn><eissn>1872-9142</eissn><abstract>► The complement lectin pathway is rapidly activated by trypanosomes and Leishmania. ► The expression of stage-specific complement receptors confers resistance to lysis. ► The main mechanisms involves C3 convertase inhibition and shedding of C3b and MAC. ► Host genetic deficiency of the lectin pathway correlates to infection susceptibility. ► Disease progression is also aggravated by host deficiency of the lectin pathway.
Studies in the past decade have demonstrated a crucial role for the complement lectin pathway in host defence against protozoan microbes. Recognition of pathogen surface molecules by mannan-binding lectin and ficolins revealed new mechanisms of innate immune defence and a diversity of parasite strategies of immune evasion. In the present review, we will discuss the current knowledge of: (1) the molecular mechanism of lectin pathway activation by trypanosomes; (2) the mechanisms of complement evasion by trypanosomes; and (3) host genetic deficiencies of complement lectin pathway factors that contribute to infection susceptibility and disease progression. This review will focus on trypanosomatids, the parasites that cause Chagas disease, leishmaniasis and sleeping sickness (African trypanosomiasis).</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>23063472</pmid><doi>10.1016/j.molimm.2012.08.015</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Chagas disease Chagas Disease - genetics Chagas Disease - immunology Chagas Disease - metabolism Complement Pathway, Mannose-Binding Lectin - genetics Complement Pathway, Mannose-Binding Lectin - immunology Complement system Complement System Proteins - genetics Complement System Proteins - immunology Ficolins Gene Expression Host-Parasite Interactions Humans Immune Evasion Immunity, Innate Innate immunity Lectin pathway Lectins - genetics Lectins - immunology Mannose-Binding Lectin - genetics Mannose-Binding Lectin - immunology Parasite host cell interaction T. cruzi Trypanosoma - genetics Trypanosoma - immunology Trypanosomiasis Trypanosomiasis, African - genetics Trypanosomiasis, African - immunology Trypanosomiasis, African - metabolism Variant Surface Glycoproteins, Trypanosoma - genetics Variant Surface Glycoproteins, Trypanosoma - immunology |
| title | Mechanisms of complement lectin pathway activation and resistance by trypanosomatid parasites |
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