Effect of Canine Hyperadrenocorticism on Coagulation Parameters
Background Hyperadrenocorticism (HAC) has been associated with thrombotic disease in dogs. Hypothesis The purpose of this study was to use thromboelastography (TEG) and measurement of thrombin generation (TG) to characterize the hypercoagulable state in dogs with HAC. We hypothesized that dogs with...
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| Veröffentlicht in: | Journal of veterinary internal medicine 2013-01, Vol.27 (1), p.207-211 |
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| creator | Rose, L. Dunn, M.E. Bédard, C. |
| description | Background
Hyperadrenocorticism (HAC) has been associated with thrombotic disease in dogs.
Hypothesis
The purpose of this study was to use thromboelastography (TEG) and measurement of thrombin generation (TG) to characterize the hypercoagulable state in dogs with HAC. We hypothesized that dogs with HAC would have a hypercoagulable profile on TEG tracings and an increase in thrombin generation as measured by endogenous thrombin potential (ETP).
Animals
Sixteen dogs with HAC. Dogs were compared with a population of normal dogs used to obtain reference intervals.
Methods
TEG tracings on citrated whole blood were obtained from 15 dogs, and TG measurements on frozen‐thawed platelet‐poor plasma (PPP) were obtained from 15 dogs.
Results
For the TEG analysis, when results of individual dogs were compared with the reference interval, 12/15 dogs had at least 1 parameter associated with hypercoagulability. When the population of HAC dogs was compared with a population of healthy dogs, HAC dogs had decreases in R and K and increases in α and MA values. The ETP was increased when the HAC group was compared with a population of normal dogs. However, only 3/15 dogs had an ETP above reference interval, and 1/15 had a decreased lag time.
Conclusion and Clinical Importance
Of 16 dogs with HAC, 12/15 had evidence of hypercoagulability when evaluated by TEG, 4/15 when evaluated by TG, and 2 dogs had increases in ETP and MA. |
| doi_str_mv | 10.1111/jvim.12005 |
| format | Article |
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Hyperadrenocorticism (HAC) has been associated with thrombotic disease in dogs.
Hypothesis
The purpose of this study was to use thromboelastography (TEG) and measurement of thrombin generation (TG) to characterize the hypercoagulable state in dogs with HAC. We hypothesized that dogs with HAC would have a hypercoagulable profile on TEG tracings and an increase in thrombin generation as measured by endogenous thrombin potential (ETP).
Animals
Sixteen dogs with HAC. Dogs were compared with a population of normal dogs used to obtain reference intervals.
Methods
TEG tracings on citrated whole blood were obtained from 15 dogs, and TG measurements on frozen‐thawed platelet‐poor plasma (PPP) were obtained from 15 dogs.
Results
For the TEG analysis, when results of individual dogs were compared with the reference interval, 12/15 dogs had at least 1 parameter associated with hypercoagulability. When the population of HAC dogs was compared with a population of healthy dogs, HAC dogs had decreases in R and K and increases in α and MA values. The ETP was increased when the HAC group was compared with a population of normal dogs. However, only 3/15 dogs had an ETP above reference interval, and 1/15 had a decreased lag time.
Conclusion and Clinical Importance
Of 16 dogs with HAC, 12/15 had evidence of hypercoagulability when evaluated by TEG, 4/15 when evaluated by TG, and 2 dogs had increases in ETP and MA.</description><identifier>ISSN: 0891-6640</identifier><identifier>EISSN: 1939-1676</identifier><identifier>DOI: 10.1111/jvim.12005</identifier><identifier>PMID: 23278831</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adrenocortical Hyperfunction - complications ; Adrenocortical Hyperfunction - veterinary ; Animals ; Blood Coagulation Disorders - etiology ; Blood Coagulation Disorders - veterinary ; Dog Diseases - blood ; Dogs ; Female ; Hemostasis ; Male ; TEG ; Thrombelastography ; Thrombin - metabolism ; Thrombin generation</subject><ispartof>Journal of veterinary internal medicine, 2013-01, Vol.27 (1), p.207-211</ispartof><rights>Copyright © 2013 by the American College of Veterinary Internal Medicine</rights><rights>Copyright © 2013 by the American College of Veterinary Internal Medicine.</rights><rights>2013. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3955-38ba2665a6319c77f0c075ec0161d6d18102f91a7af104efe26cbd81cdea33d73</citedby><cites>FETCH-LOGICAL-c3955-38ba2665a6319c77f0c075ec0161d6d18102f91a7af104efe26cbd81cdea33d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjvim.12005$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjvim.12005$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,11541,27901,27902,45550,45551,46027,46451</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjvim.12005$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23278831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rose, L.</creatorcontrib><creatorcontrib>Dunn, M.E.</creatorcontrib><creatorcontrib>Bédard, C.</creatorcontrib><title>Effect of Canine Hyperadrenocorticism on Coagulation Parameters</title><title>Journal of veterinary internal medicine</title><addtitle>J Vet Intern Med</addtitle><description>Background
Hyperadrenocorticism (HAC) has been associated with thrombotic disease in dogs.
Hypothesis
The purpose of this study was to use thromboelastography (TEG) and measurement of thrombin generation (TG) to characterize the hypercoagulable state in dogs with HAC. We hypothesized that dogs with HAC would have a hypercoagulable profile on TEG tracings and an increase in thrombin generation as measured by endogenous thrombin potential (ETP).
Animals
Sixteen dogs with HAC. Dogs were compared with a population of normal dogs used to obtain reference intervals.
Methods
TEG tracings on citrated whole blood were obtained from 15 dogs, and TG measurements on frozen‐thawed platelet‐poor plasma (PPP) were obtained from 15 dogs.
Results
For the TEG analysis, when results of individual dogs were compared with the reference interval, 12/15 dogs had at least 1 parameter associated with hypercoagulability. When the population of HAC dogs was compared with a population of healthy dogs, HAC dogs had decreases in R and K and increases in α and MA values. The ETP was increased when the HAC group was compared with a population of normal dogs. However, only 3/15 dogs had an ETP above reference interval, and 1/15 had a decreased lag time.
Conclusion and Clinical Importance
Of 16 dogs with HAC, 12/15 had evidence of hypercoagulability when evaluated by TEG, 4/15 when evaluated by TG, and 2 dogs had increases in ETP and MA.</description><subject>Adrenocortical Hyperfunction - complications</subject><subject>Adrenocortical Hyperfunction - veterinary</subject><subject>Animals</subject><subject>Blood Coagulation Disorders - etiology</subject><subject>Blood Coagulation Disorders - veterinary</subject><subject>Dog Diseases - blood</subject><subject>Dogs</subject><subject>Female</subject><subject>Hemostasis</subject><subject>Male</subject><subject>TEG</subject><subject>Thrombelastography</subject><subject>Thrombin - metabolism</subject><subject>Thrombin generation</subject><issn>0891-6640</issn><issn>1939-1676</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhq0K1C6FCz8AReJSIaX1xGs7PqF2VfrNh7QtEhfL64yRlyRe7AS6_74u2_bAoXOZOTzvq9FDyFug-5DnYPnHd_tQUcq3yAQUUyUIKV6QCa0VlEJM6Q55ldKS0opzLrfJTsUqWdcMJuTjsXNohyK4YmZ632Nxul5hNE3EPtgQB2996orQF7Ngfo6tGXy-v5poOhwwptfkpTNtwjcPe5dcfzqez07Lyy8nZ7PDy9IyxXnJ6oWphOBGMFBWSkctlRwtBQGNaKAGWjkFRhoHdIoOK2EXTQ22QcNYI9ku2dv0rmL4PWIadOeTxbY1PYYxaagkmyo1VTyj7_9Dl2GMff5OM5rFZB-UZurDhrIxpBTR6VX0nYlrDVTfa9X3WvU_rRl-91A5LjpsntBHjxmADfDXt7h-pkqf35xdPZaWm4xPA94-ZUz8pYVkkuvvn080P_92dKF-zPWc3QF5tpBt</recordid><startdate>201301</startdate><enddate>201301</enddate><creator>Rose, L.</creator><creator>Dunn, M.E.</creator><creator>Bédard, C.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201301</creationdate><title>Effect of Canine Hyperadrenocorticism on Coagulation Parameters</title><author>Rose, L. ; Dunn, M.E. ; Bédard, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3955-38ba2665a6319c77f0c075ec0161d6d18102f91a7af104efe26cbd81cdea33d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adrenocortical Hyperfunction - complications</topic><topic>Adrenocortical Hyperfunction - veterinary</topic><topic>Animals</topic><topic>Blood Coagulation Disorders - etiology</topic><topic>Blood Coagulation Disorders - veterinary</topic><topic>Dog Diseases - blood</topic><topic>Dogs</topic><topic>Female</topic><topic>Hemostasis</topic><topic>Male</topic><topic>TEG</topic><topic>Thrombelastography</topic><topic>Thrombin - metabolism</topic><topic>Thrombin generation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rose, L.</creatorcontrib><creatorcontrib>Dunn, M.E.</creatorcontrib><creatorcontrib>Bédard, C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of veterinary internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Rose, L.</au><au>Dunn, M.E.</au><au>Bédard, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Canine Hyperadrenocorticism on Coagulation Parameters</atitle><jtitle>Journal of veterinary internal medicine</jtitle><addtitle>J Vet Intern Med</addtitle><date>2013-01</date><risdate>2013</risdate><volume>27</volume><issue>1</issue><spage>207</spage><epage>211</epage><pages>207-211</pages><issn>0891-6640</issn><eissn>1939-1676</eissn><abstract>Background
Hyperadrenocorticism (HAC) has been associated with thrombotic disease in dogs.
Hypothesis
The purpose of this study was to use thromboelastography (TEG) and measurement of thrombin generation (TG) to characterize the hypercoagulable state in dogs with HAC. We hypothesized that dogs with HAC would have a hypercoagulable profile on TEG tracings and an increase in thrombin generation as measured by endogenous thrombin potential (ETP).
Animals
Sixteen dogs with HAC. Dogs were compared with a population of normal dogs used to obtain reference intervals.
Methods
TEG tracings on citrated whole blood were obtained from 15 dogs, and TG measurements on frozen‐thawed platelet‐poor plasma (PPP) were obtained from 15 dogs.
Results
For the TEG analysis, when results of individual dogs were compared with the reference interval, 12/15 dogs had at least 1 parameter associated with hypercoagulability. When the population of HAC dogs was compared with a population of healthy dogs, HAC dogs had decreases in R and K and increases in α and MA values. The ETP was increased when the HAC group was compared with a population of normal dogs. However, only 3/15 dogs had an ETP above reference interval, and 1/15 had a decreased lag time.
Conclusion and Clinical Importance
Of 16 dogs with HAC, 12/15 had evidence of hypercoagulability when evaluated by TEG, 4/15 when evaluated by TG, and 2 dogs had increases in ETP and MA.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23278831</pmid><doi>10.1111/jvim.12005</doi><tpages>5</tpages></addata></record> |
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| source | Wiley Online Library Open Access |
| subjects | Adrenocortical Hyperfunction - complications Adrenocortical Hyperfunction - veterinary Animals Blood Coagulation Disorders - etiology Blood Coagulation Disorders - veterinary Dog Diseases - blood Dogs Female Hemostasis Male TEG Thrombelastography Thrombin - metabolism Thrombin generation |
| title | Effect of Canine Hyperadrenocorticism on Coagulation Parameters |
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