The prevalence of thyroid disease in patients with vitiligo: a systematic review
Summary Background Thyroid disease has been suggested to be associated with vitiligo. However, the outcomes of prevalence studies on thyroid disease in vitiligo vary widely. Objectives To summarize and critically appraise current evidence of the prevalence of thyroid diseases in vitiligo. Methods ...
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| Veröffentlicht in: | British journal of dermatology (1951) 2012-12, Vol.167 (6), p.1224-1235 |
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| container_title | British journal of dermatology (1951) |
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| creator | Vrijman, C. Kroon, M.W. Limpens, J. Leeflang, M.M.G. Luiten, R.M. van der Veen, J.P.W. Wolkerstorfer, A. Spuls, P.I. |
| description | Summary
Background Thyroid disease has been suggested to be associated with vitiligo. However, the outcomes of prevalence studies on thyroid disease in vitiligo vary widely.
Objectives To summarize and critically appraise current evidence of the prevalence of thyroid diseases in vitiligo.
Methods A systematic review was performed searching the electronic databases OVID MEDLINE, OVID EMBASE and PubMed. Guidelines for the critical appraisal of studies on prevalence of a health problem were adapted to evaluate the methodological quality of the included studies. Results were analysed in a meta‐analysis with a risk ratio (RR).
Results Forty‐eight studies published between 1968 and 2012 met the inclusion criteria. Most of the studies (50%) were of fair methodological quality, whereas 18 studies (38%) were of poor quality and six studies (12%) were of good quality. Thyroid disease, autoimmune thyroid disease and presence of thyroid‐specific autoantibodies showed a mean prevalence of, respectively, 15·1%, 14·3% and 20·8% in patients with vitiligo and an RR of, respectively, 1·9, 2·5 and 5·2 (all statistically significant). This review shows an increased prevalence and an increased risk of (autoimmune) thyroid disease in patients with vitiligo compared with nonvitiligo. This risk seems to increase with age.
Conclusions Clinicians should be aware of this increased risk in patients with vitiligo and should be attentive for symptoms of thyroid disease. To make recommendations on screening for thyroid disease in patients with vitiligo future research of good methodological quality, including differentiation of vitiligo types and the use of standardized outcome measures, is needed. |
| doi_str_mv | 10.1111/j.1365-2133.2012.11198.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1273493091</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2311145533</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4668-a30352a67b59ab2c51fe1de904be2449fbea58c5555efc814c367dd412050deb3</originalsourceid><addsrcrecordid>eNqNkV1v0zAUhi0EYmXwF5AlhMRNiu1jOwkXSKPA-JgGaEO7tBznhLqkSbHTtf33OGspElecG1v2c17bjwmhnE15qpeLKQetMsEBpoJxMa6WxXR7j0yOG_fJhDGWZ6zUcEIexbhgjANT7CE5EaLQTJdqQr5ez5GuAt7aFjuHtG_oMN-F3te09hFtROo7urKDx26IdOOHOb31g2_9j_4VtTTu4oDLtO1oCvG4eUweNLaN-OQwnpLv799dzz5kF1_OP87OLjIntS4yCwyUsDqvVGkr4RRvkNdYMlmhkLJsKrSqcCoVNq7g0oHO61pykV5QYwWn5MU-dxX6X2uMg1n66LBtbYf9OhoucpAlsJIn9Nk_6KJfhy7dzghI5qRSAIkq9pQLfYwBG7MKfmnDznBmRutmYUa5ZpRrRuvmzrrZptanhwPW1RLrY-MfzQl4fgBsdLZtgu2cj385nUsupUzc6z238S3u_vsC5s2nt3fTFJDtA3z6lu0xwIafRueQK3NzeW5u4Gr2DS6vzGf4Dc3Hq7c</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2311145533</pqid></control><display><type>article</type><title>The prevalence of thyroid disease in patients with vitiligo: a systematic review</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Vrijman, C. ; Kroon, M.W. ; Limpens, J. ; Leeflang, M.M.G. ; Luiten, R.M. ; van der Veen, J.P.W. ; Wolkerstorfer, A. ; Spuls, P.I.</creator><creatorcontrib>Vrijman, C. ; Kroon, M.W. ; Limpens, J. ; Leeflang, M.M.G. ; Luiten, R.M. ; van der Veen, J.P.W. ; Wolkerstorfer, A. ; Spuls, P.I.</creatorcontrib><description>Summary
Background Thyroid disease has been suggested to be associated with vitiligo. However, the outcomes of prevalence studies on thyroid disease in vitiligo vary widely.
Objectives To summarize and critically appraise current evidence of the prevalence of thyroid diseases in vitiligo.
Methods A systematic review was performed searching the electronic databases OVID MEDLINE, OVID EMBASE and PubMed. Guidelines for the critical appraisal of studies on prevalence of a health problem were adapted to evaluate the methodological quality of the included studies. Results were analysed in a meta‐analysis with a risk ratio (RR).
Results Forty‐eight studies published between 1968 and 2012 met the inclusion criteria. Most of the studies (50%) were of fair methodological quality, whereas 18 studies (38%) were of poor quality and six studies (12%) were of good quality. Thyroid disease, autoimmune thyroid disease and presence of thyroid‐specific autoantibodies showed a mean prevalence of, respectively, 15·1%, 14·3% and 20·8% in patients with vitiligo and an RR of, respectively, 1·9, 2·5 and 5·2 (all statistically significant). This review shows an increased prevalence and an increased risk of (autoimmune) thyroid disease in patients with vitiligo compared with nonvitiligo. This risk seems to increase with age.
Conclusions Clinicians should be aware of this increased risk in patients with vitiligo and should be attentive for symptoms of thyroid disease. To make recommendations on screening for thyroid disease in patients with vitiligo future research of good methodological quality, including differentiation of vitiligo types and the use of standardized outcome measures, is needed.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.2012.11198.x</identifier><identifier>PMID: 22860695</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Age Factors ; Antibodies - immunology ; Autoantibodies ; Autoantibodies - immunology ; Biological and medical sciences ; Dermatology ; Endocrinopathies ; Epidemiology ; General aspects ; Humans ; Medical sciences ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Pigmentary diseases of the skin ; Prevalence ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Quality ; Risk Factors ; Severity of Illness Index ; Statistical analysis ; Systematic review ; Thyroid diseases ; Thyroid Diseases - epidemiology ; Thyroid Diseases - immunology ; Thyroid. Thyroid axis (diseases) ; Vitiligo ; Vitiligo - epidemiology ; Vitiligo - immunology</subject><ispartof>British journal of dermatology (1951), 2012-12, Vol.167 (6), p.1224-1235</ispartof><rights>2012 The Authors. BJD © 2012 British Association of Dermatologists 2012</rights><rights>2014 INIST-CNRS</rights><rights>2012 The Authors. BJD © 2012 British Association of Dermatologists 2012.</rights><rights>Copyright Blackwell Publishing Ltd. Dec 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4668-a30352a67b59ab2c51fe1de904be2449fbea58c5555efc814c367dd412050deb3</citedby><cites>FETCH-LOGICAL-c4668-a30352a67b59ab2c51fe1de904be2449fbea58c5555efc814c367dd412050deb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.2012.11198.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.2012.11198.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26741444$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22860695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vrijman, C.</creatorcontrib><creatorcontrib>Kroon, M.W.</creatorcontrib><creatorcontrib>Limpens, J.</creatorcontrib><creatorcontrib>Leeflang, M.M.G.</creatorcontrib><creatorcontrib>Luiten, R.M.</creatorcontrib><creatorcontrib>van der Veen, J.P.W.</creatorcontrib><creatorcontrib>Wolkerstorfer, A.</creatorcontrib><creatorcontrib>Spuls, P.I.</creatorcontrib><title>The prevalence of thyroid disease in patients with vitiligo: a systematic review</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary
Background Thyroid disease has been suggested to be associated with vitiligo. However, the outcomes of prevalence studies on thyroid disease in vitiligo vary widely.
Objectives To summarize and critically appraise current evidence of the prevalence of thyroid diseases in vitiligo.
Methods A systematic review was performed searching the electronic databases OVID MEDLINE, OVID EMBASE and PubMed. Guidelines for the critical appraisal of studies on prevalence of a health problem were adapted to evaluate the methodological quality of the included studies. Results were analysed in a meta‐analysis with a risk ratio (RR).
Results Forty‐eight studies published between 1968 and 2012 met the inclusion criteria. Most of the studies (50%) were of fair methodological quality, whereas 18 studies (38%) were of poor quality and six studies (12%) were of good quality. Thyroid disease, autoimmune thyroid disease and presence of thyroid‐specific autoantibodies showed a mean prevalence of, respectively, 15·1%, 14·3% and 20·8% in patients with vitiligo and an RR of, respectively, 1·9, 2·5 and 5·2 (all statistically significant). This review shows an increased prevalence and an increased risk of (autoimmune) thyroid disease in patients with vitiligo compared with nonvitiligo. This risk seems to increase with age.
Conclusions Clinicians should be aware of this increased risk in patients with vitiligo and should be attentive for symptoms of thyroid disease. To make recommendations on screening for thyroid disease in patients with vitiligo future research of good methodological quality, including differentiation of vitiligo types and the use of standardized outcome measures, is needed.</description><subject>Age Factors</subject><subject>Antibodies - immunology</subject><subject>Autoantibodies</subject><subject>Autoantibodies - immunology</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Endocrinopathies</subject><subject>Epidemiology</subject><subject>General aspects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Pigmentary diseases of the skin</subject><subject>Prevalence</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Quality</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Statistical analysis</subject><subject>Systematic review</subject><subject>Thyroid diseases</subject><subject>Thyroid Diseases - epidemiology</subject><subject>Thyroid Diseases - immunology</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Vitiligo</subject><subject>Vitiligo - epidemiology</subject><subject>Vitiligo - immunology</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV1v0zAUhi0EYmXwF5AlhMRNiu1jOwkXSKPA-JgGaEO7tBznhLqkSbHTtf33OGspElecG1v2c17bjwmhnE15qpeLKQetMsEBpoJxMa6WxXR7j0yOG_fJhDGWZ6zUcEIexbhgjANT7CE5EaLQTJdqQr5ez5GuAt7aFjuHtG_oMN-F3te09hFtROo7urKDx26IdOOHOb31g2_9j_4VtTTu4oDLtO1oCvG4eUweNLaN-OQwnpLv799dzz5kF1_OP87OLjIntS4yCwyUsDqvVGkr4RRvkNdYMlmhkLJsKrSqcCoVNq7g0oHO61pykV5QYwWn5MU-dxX6X2uMg1n66LBtbYf9OhoucpAlsJIn9Nk_6KJfhy7dzghI5qRSAIkq9pQLfYwBG7MKfmnDznBmRutmYUa5ZpRrRuvmzrrZptanhwPW1RLrY-MfzQl4fgBsdLZtgu2cj385nUsupUzc6z238S3u_vsC5s2nt3fTFJDtA3z6lu0xwIafRueQK3NzeW5u4Gr2DS6vzGf4Dc3Hq7c</recordid><startdate>201212</startdate><enddate>201212</enddate><creator>Vrijman, C.</creator><creator>Kroon, M.W.</creator><creator>Limpens, J.</creator><creator>Leeflang, M.M.G.</creator><creator>Luiten, R.M.</creator><creator>van der Veen, J.P.W.</creator><creator>Wolkerstorfer, A.</creator><creator>Spuls, P.I.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201212</creationdate><title>The prevalence of thyroid disease in patients with vitiligo: a systematic review</title><author>Vrijman, C. ; Kroon, M.W. ; Limpens, J. ; Leeflang, M.M.G. ; Luiten, R.M. ; van der Veen, J.P.W. ; Wolkerstorfer, A. ; Spuls, P.I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4668-a30352a67b59ab2c51fe1de904be2449fbea58c5555efc814c367dd412050deb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age Factors</topic><topic>Antibodies - immunology</topic><topic>Autoantibodies</topic><topic>Autoantibodies - immunology</topic><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>Endocrinopathies</topic><topic>Epidemiology</topic><topic>General aspects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Pigmentary diseases of the skin</topic><topic>Prevalence</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Quality</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Statistical analysis</topic><topic>Systematic review</topic><topic>Thyroid diseases</topic><topic>Thyroid Diseases - epidemiology</topic><topic>Thyroid Diseases - immunology</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Vitiligo</topic><topic>Vitiligo - epidemiology</topic><topic>Vitiligo - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vrijman, C.</creatorcontrib><creatorcontrib>Kroon, M.W.</creatorcontrib><creatorcontrib>Limpens, J.</creatorcontrib><creatorcontrib>Leeflang, M.M.G.</creatorcontrib><creatorcontrib>Luiten, R.M.</creatorcontrib><creatorcontrib>van der Veen, J.P.W.</creatorcontrib><creatorcontrib>Wolkerstorfer, A.</creatorcontrib><creatorcontrib>Spuls, P.I.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vrijman, C.</au><au>Kroon, M.W.</au><au>Limpens, J.</au><au>Leeflang, M.M.G.</au><au>Luiten, R.M.</au><au>van der Veen, J.P.W.</au><au>Wolkerstorfer, A.</au><au>Spuls, P.I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prevalence of thyroid disease in patients with vitiligo: a systematic review</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2012-12</date><risdate>2012</risdate><volume>167</volume><issue>6</issue><spage>1224</spage><epage>1235</epage><pages>1224-1235</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>Summary
Background Thyroid disease has been suggested to be associated with vitiligo. However, the outcomes of prevalence studies on thyroid disease in vitiligo vary widely.
Objectives To summarize and critically appraise current evidence of the prevalence of thyroid diseases in vitiligo.
Methods A systematic review was performed searching the electronic databases OVID MEDLINE, OVID EMBASE and PubMed. Guidelines for the critical appraisal of studies on prevalence of a health problem were adapted to evaluate the methodological quality of the included studies. Results were analysed in a meta‐analysis with a risk ratio (RR).
Results Forty‐eight studies published between 1968 and 2012 met the inclusion criteria. Most of the studies (50%) were of fair methodological quality, whereas 18 studies (38%) were of poor quality and six studies (12%) were of good quality. Thyroid disease, autoimmune thyroid disease and presence of thyroid‐specific autoantibodies showed a mean prevalence of, respectively, 15·1%, 14·3% and 20·8% in patients with vitiligo and an RR of, respectively, 1·9, 2·5 and 5·2 (all statistically significant). This review shows an increased prevalence and an increased risk of (autoimmune) thyroid disease in patients with vitiligo compared with nonvitiligo. This risk seems to increase with age.
Conclusions Clinicians should be aware of this increased risk in patients with vitiligo and should be attentive for symptoms of thyroid disease. To make recommendations on screening for thyroid disease in patients with vitiligo future research of good methodological quality, including differentiation of vitiligo types and the use of standardized outcome measures, is needed.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22860695</pmid><doi>10.1111/j.1365-2133.2012.11198.x</doi><tpages>12</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Age Factors Antibodies - immunology Autoantibodies Autoantibodies - immunology Biological and medical sciences Dermatology Endocrinopathies Epidemiology General aspects Humans Medical sciences Non tumoral diseases. Target tissue resistance. Benign neoplasms Pigmentary diseases of the skin Prevalence Public health. Hygiene Public health. Hygiene-occupational medicine Quality Risk Factors Severity of Illness Index Statistical analysis Systematic review Thyroid diseases Thyroid Diseases - epidemiology Thyroid Diseases - immunology Thyroid. Thyroid axis (diseases) Vitiligo Vitiligo - epidemiology Vitiligo - immunology |
| title | The prevalence of thyroid disease in patients with vitiligo: a systematic review |
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