Pulmonary manifestations of anti-ARS antibody positive interstitial pneumonia – With or without PM/DM

Summary Background Autoantibodies against aminoacyl-tRNA synthetases (ARS) have been found to be highly specific for polymyositis and dermatomyositis (PM/DM) and to correlate strongly with complicating interstitial pneumonia (IP). The aim of the present study was to compare the clinical presentation...

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Veröffentlicht in:Respiratory medicine 2013-01, Vol.107 (1), p.128-133
Hauptverfasser: Takato, Hazuki, Waseda, Yuko, Watanabe, Satoshi, Inuzuka, Kanako, Katayama, Nobuyuki, Ichikawa, Yukari, Yasui, Masahide, Fujimura, Masaki
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container_end_page 133
container_issue 1
container_start_page 128
container_title Respiratory medicine
container_volume 107
creator Takato, Hazuki
Waseda, Yuko
Watanabe, Satoshi
Inuzuka, Kanako
Katayama, Nobuyuki
Ichikawa, Yukari
Yasui, Masahide
Fujimura, Masaki
description Summary Background Autoantibodies against aminoacyl-tRNA synthetases (ARS) have been found to be highly specific for polymyositis and dermatomyositis (PM/DM) and to correlate strongly with complicating interstitial pneumonia (IP). The aim of the present study was to compare the clinical presentations of anti-ARS antibody-positive IP patients with or without manifestations of PM/DM. Methods We retrospectively examined 36 IP patients with anti-ARS antibodies. Sixteen patients presented with and 20 without the features of PM/DM. They were divided into PM/DM-IP and idiopathic-IP (IIP) groups. Clinical symptoms, findings on physical examination, laboratory data, pulmonary function, computed tomography (CT), and bronchoalveolar lavage fluid (BALF) cell counts were compared. Results Skin findings, myalgia, and elevation of serum creatinine kinase were found in the PM/DM-IP group. Features common to both groups included: volume loss in lower bilateral lobes; ground-glass opacities, reticular shadows and traction bronchiectasis on chest CT; high percentage of lymphocytes (IIP: 44.0% ± 21.0% (mean ± SD), PM/DM-IP: 50.5% ± 23.5%) and low CD4/8 ratios (IIP: 0.36 ± 0.34, PM/DM-IP: 0.44 ± 0.42) in BALF; decreased pulmonary function, including percentage of predicted vital capacity (VC) (IIP: 80.1% ± 15.4%, PM/DM-IP: 73.6% ± 16.4%), residual volume (RV) (IIP: 70.7% ± 21.7%, PM/DM-IP: 71.5% ± 17.1%), total lung capacity (TLC) (IIP: 73.4% ± 13.6%, PM/DM-IP: 71.6% ± 13.0%), and diffusing capacity DLco (IIP: 57.5% ± 26.7%, PM/DM-IP: 46.4% ± 10.3%). Both groups achieved good responses to initial corticosteroid or immunosuppressant therapy. Conclusion Patients with anti-ARS antibody-positive IP have common pulmonary manifestations regardless of the presence of PM/DM.
doi_str_mv 10.1016/j.rmed.2012.09.005
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The aim of the present study was to compare the clinical presentations of anti-ARS antibody-positive IP patients with or without manifestations of PM/DM. Methods We retrospectively examined 36 IP patients with anti-ARS antibodies. Sixteen patients presented with and 20 without the features of PM/DM. They were divided into PM/DM-IP and idiopathic-IP (IIP) groups. Clinical symptoms, findings on physical examination, laboratory data, pulmonary function, computed tomography (CT), and bronchoalveolar lavage fluid (BALF) cell counts were compared. Results Skin findings, myalgia, and elevation of serum creatinine kinase were found in the PM/DM-IP group. Features common to both groups included: volume loss in lower bilateral lobes; ground-glass opacities, reticular shadows and traction bronchiectasis on chest CT; high percentage of lymphocytes (IIP: 44.0% ± 21.0% (mean ± SD), PM/DM-IP: 50.5% ± 23.5%) and low CD4/8 ratios (IIP: 0.36 ± 0.34, PM/DM-IP: 0.44 ± 0.42) in BALF; decreased pulmonary function, including percentage of predicted vital capacity (VC) (IIP: 80.1% ± 15.4%, PM/DM-IP: 73.6% ± 16.4%), residual volume (RV) (IIP: 70.7% ± 21.7%, PM/DM-IP: 71.5% ± 17.1%), total lung capacity (TLC) (IIP: 73.4% ± 13.6%, PM/DM-IP: 71.6% ± 13.0%), and diffusing capacity DLco (IIP: 57.5% ± 26.7%, PM/DM-IP: 46.4% ± 10.3%). Both groups achieved good responses to initial corticosteroid or immunosuppressant therapy. Conclusion Patients with anti-ARS antibody-positive IP have common pulmonary manifestations regardless of the presence of PM/DM.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2012.09.005</identifier><identifier>PMID: 23137883</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Age ; Aged ; Amino Acyl-tRNA Synthetases - immunology ; Anti-ARS antibody ; Autoantibodies - analysis ; Biological and medical sciences ; Bronchoalveolar Lavage Fluid - cytology ; Dermatomyositis - complications ; Dermatomyositis - immunology ; Female ; Fever ; Hospitals ; Humans ; Interstital lung disease ; Lung Diseases, Interstitial - diagnostic imaging ; Lung Diseases, Interstitial - etiology ; Lung Diseases, Interstitial - immunology ; Lung Diseases, Interstitial - physiopathology ; Lung fibrosis ; Lungs ; Male ; Medical sciences ; Middle Aged ; Patients ; Personal relationships ; Physical Examination - methods ; Pneumology ; Polymyositis - complications ; Polymyositis - immunology ; Polymyositis/dermatomyositis ; Pulmonary/Respiratory ; Raynaud disease ; Respiratory system : syndromes and miscellaneous diseases ; Retrospective Studies ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Scleroderma ; Tomography, X-Ray Computed ; Total Lung Capacity ; Women ; Young Adult</subject><ispartof>Respiratory medicine, 2013-01, Vol.107 (1), p.128-133</ispartof><rights>2012</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012. Published by Elsevier Ltd.</rights><rights>Copyright Elsevier Limited Jan 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-e13cbecb85df60e790a80657602f0417b7a4bd94b55e4ffbbc390dab0d2896143</citedby><cites>FETCH-LOGICAL-c469t-e13cbecb85df60e790a80657602f0417b7a4bd94b55e4ffbbc390dab0d2896143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rmed.2012.09.005$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=26786247$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23137883$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takato, Hazuki</creatorcontrib><creatorcontrib>Waseda, Yuko</creatorcontrib><creatorcontrib>Watanabe, Satoshi</creatorcontrib><creatorcontrib>Inuzuka, Kanako</creatorcontrib><creatorcontrib>Katayama, Nobuyuki</creatorcontrib><creatorcontrib>Ichikawa, Yukari</creatorcontrib><creatorcontrib>Yasui, Masahide</creatorcontrib><creatorcontrib>Fujimura, Masaki</creatorcontrib><title>Pulmonary manifestations of anti-ARS antibody positive interstitial pneumonia – With or without PM/DM</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Summary Background Autoantibodies against aminoacyl-tRNA synthetases (ARS) have been found to be highly specific for polymyositis and dermatomyositis (PM/DM) and to correlate strongly with complicating interstitial pneumonia (IP). The aim of the present study was to compare the clinical presentations of anti-ARS antibody-positive IP patients with or without manifestations of PM/DM. Methods We retrospectively examined 36 IP patients with anti-ARS antibodies. Sixteen patients presented with and 20 without the features of PM/DM. They were divided into PM/DM-IP and idiopathic-IP (IIP) groups. Clinical symptoms, findings on physical examination, laboratory data, pulmonary function, computed tomography (CT), and bronchoalveolar lavage fluid (BALF) cell counts were compared. Results Skin findings, myalgia, and elevation of serum creatinine kinase were found in the PM/DM-IP group. Features common to both groups included: volume loss in lower bilateral lobes; ground-glass opacities, reticular shadows and traction bronchiectasis on chest CT; high percentage of lymphocytes (IIP: 44.0% ± 21.0% (mean ± SD), PM/DM-IP: 50.5% ± 23.5%) and low CD4/8 ratios (IIP: 0.36 ± 0.34, PM/DM-IP: 0.44 ± 0.42) in BALF; decreased pulmonary function, including percentage of predicted vital capacity (VC) (IIP: 80.1% ± 15.4%, PM/DM-IP: 73.6% ± 16.4%), residual volume (RV) (IIP: 70.7% ± 21.7%, PM/DM-IP: 71.5% ± 17.1%), total lung capacity (TLC) (IIP: 73.4% ± 13.6%, PM/DM-IP: 71.6% ± 13.0%), and diffusing capacity DLco (IIP: 57.5% ± 26.7%, PM/DM-IP: 46.4% ± 10.3%). Both groups achieved good responses to initial corticosteroid or immunosuppressant therapy. Conclusion Patients with anti-ARS antibody-positive IP have common pulmonary manifestations regardless of the presence of PM/DM.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Amino Acyl-tRNA Synthetases - immunology</subject><subject>Anti-ARS antibody</subject><subject>Autoantibodies - analysis</subject><subject>Biological and medical sciences</subject><subject>Bronchoalveolar Lavage Fluid - cytology</subject><subject>Dermatomyositis - complications</subject><subject>Dermatomyositis - immunology</subject><subject>Female</subject><subject>Fever</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Interstital lung disease</subject><subject>Lung Diseases, Interstitial - diagnostic imaging</subject><subject>Lung Diseases, Interstitial - etiology</subject><subject>Lung Diseases, Interstitial - immunology</subject><subject>Lung Diseases, Interstitial - physiopathology</subject><subject>Lung fibrosis</subject><subject>Lungs</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Personal relationships</subject><subject>Physical Examination - methods</subject><subject>Pneumology</subject><subject>Polymyositis - complications</subject><subject>Polymyositis - immunology</subject><subject>Polymyositis/dermatomyositis</subject><subject>Pulmonary/Respiratory</subject><subject>Raynaud disease</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Retrospective Studies</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. 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Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Scleroderma</topic><topic>Tomography, X-Ray Computed</topic><topic>Total Lung Capacity</topic><topic>Women</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takato, Hazuki</creatorcontrib><creatorcontrib>Waseda, Yuko</creatorcontrib><creatorcontrib>Watanabe, Satoshi</creatorcontrib><creatorcontrib>Inuzuka, Kanako</creatorcontrib><creatorcontrib>Katayama, Nobuyuki</creatorcontrib><creatorcontrib>Ichikawa, Yukari</creatorcontrib><creatorcontrib>Yasui, Masahide</creatorcontrib><creatorcontrib>Fujimura, Masaki</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takato, Hazuki</au><au>Waseda, Yuko</au><au>Watanabe, Satoshi</au><au>Inuzuka, Kanako</au><au>Katayama, Nobuyuki</au><au>Ichikawa, Yukari</au><au>Yasui, Masahide</au><au>Fujimura, Masaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary manifestations of anti-ARS antibody positive interstitial pneumonia – With or without PM/DM</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>107</volume><issue>1</issue><spage>128</spage><epage>133</epage><pages>128-133</pages><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Summary Background Autoantibodies against aminoacyl-tRNA synthetases (ARS) have been found to be highly specific for polymyositis and dermatomyositis (PM/DM) and to correlate strongly with complicating interstitial pneumonia (IP). The aim of the present study was to compare the clinical presentations of anti-ARS antibody-positive IP patients with or without manifestations of PM/DM. Methods We retrospectively examined 36 IP patients with anti-ARS antibodies. Sixteen patients presented with and 20 without the features of PM/DM. They were divided into PM/DM-IP and idiopathic-IP (IIP) groups. Clinical symptoms, findings on physical examination, laboratory data, pulmonary function, computed tomography (CT), and bronchoalveolar lavage fluid (BALF) cell counts were compared. Results Skin findings, myalgia, and elevation of serum creatinine kinase were found in the PM/DM-IP group. Features common to both groups included: volume loss in lower bilateral lobes; ground-glass opacities, reticular shadows and traction bronchiectasis on chest CT; high percentage of lymphocytes (IIP: 44.0% ± 21.0% (mean ± SD), PM/DM-IP: 50.5% ± 23.5%) and low CD4/8 ratios (IIP: 0.36 ± 0.34, PM/DM-IP: 0.44 ± 0.42) in BALF; decreased pulmonary function, including percentage of predicted vital capacity (VC) (IIP: 80.1% ± 15.4%, PM/DM-IP: 73.6% ± 16.4%), residual volume (RV) (IIP: 70.7% ± 21.7%, PM/DM-IP: 71.5% ± 17.1%), total lung capacity (TLC) (IIP: 73.4% ± 13.6%, PM/DM-IP: 71.6% ± 13.0%), and diffusing capacity DLco (IIP: 57.5% ± 26.7%, PM/DM-IP: 46.4% ± 10.3%). Both groups achieved good responses to initial corticosteroid or immunosuppressant therapy. Conclusion Patients with anti-ARS antibody-positive IP have common pulmonary manifestations regardless of the presence of PM/DM.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>23137883</pmid><doi>10.1016/j.rmed.2012.09.005</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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subjects Adolescent
Adult
Age
Aged
Amino Acyl-tRNA Synthetases - immunology
Anti-ARS antibody
Autoantibodies - analysis
Biological and medical sciences
Bronchoalveolar Lavage Fluid - cytology
Dermatomyositis - complications
Dermatomyositis - immunology
Female
Fever
Hospitals
Humans
Interstital lung disease
Lung Diseases, Interstitial - diagnostic imaging
Lung Diseases, Interstitial - etiology
Lung Diseases, Interstitial - immunology
Lung Diseases, Interstitial - physiopathology
Lung fibrosis
Lungs
Male
Medical sciences
Middle Aged
Patients
Personal relationships
Physical Examination - methods
Pneumology
Polymyositis - complications
Polymyositis - immunology
Polymyositis/dermatomyositis
Pulmonary/Respiratory
Raynaud disease
Respiratory system : syndromes and miscellaneous diseases
Retrospective Studies
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Scleroderma
Tomography, X-Ray Computed
Total Lung Capacity
Women
Young Adult
title Pulmonary manifestations of anti-ARS antibody positive interstitial pneumonia – With or without PM/DM
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