Epithelial–mesenchymal transition transcription factor ZEB1/ZEB2 co-expression predicts poor prognosis and maintains tumor-initiating properties in head and neck cancer

Summary Objectives Both epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) properties may be involved in metastasis, which contributes to the high mortality rate of patients with head and neck cancers (HNCs). However, the mechanisms through which the EMT transcription factors ZEB1 an...

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Veröffentlicht in:	Oral oncology 2013-01, Vol.49 (1), p.34-41
Hauptverfasser:	Chu, Pen-Yuan, Hu, Fang-Wei, Yu, Cheng-Chia, Tsai, Lo-Lin, Yu, Chuan-Hang, Wu, Buor-Chang, Chen, Yi-Wei, Huang, Pin-I, Lo, Wen-Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Animals Antigens, CD - genetics Biological and medical sciences Cancer stem cells Cell Culture Techniques Cell Line, Tumor Cell Proliferation Cell Survival - genetics Cell Transformation, Neoplastic - genetics Drug Resistance, Neoplasm - genetics EMT Epithelial-Mesenchymal Transition - genetics Female Gene Knockdown Techniques Gene Silencing Glycoproteins - genetics Head and neck cancer Head and Neck Neoplasms - genetics Hematology, Oncology and Palliative Medicine Homeodomain Proteins - genetics Humans Hyaluronan Receptors - analysis Kruppel-Like Transcription Factors - genetics Lymph Nodes - pathology Lymphatic Metastasis - genetics Male Medical sciences Mice Mice, Nude Middle Aged Neoplastic Stem Cells - pathology Otolaryngology Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Peptides - genetics Prognosis Repressor Proteins - genetics RNA, Small Interfering - genetics Transcription Factors - genetics Tumors ZEB1 ZEB2 Zinc Finger E-box Binding Homeobox 2 Zinc Finger E-box-Binding Homeobox 1 Zinc Fingers - genetics
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