Is Restaging with Chest and Abdominal CT Scan after Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer Necessary?
Background There is no evidence regarding restaging of patients with locally advanced rectal cancer after a long course of neoadjuvant radiotherapy with or without chemotherapy. This study evaluated the value of restaging with chest and abdominal computed tomographic (CT) scan after radiotherapy. Me...
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| Veröffentlicht in: | Annals of surgical oncology 2013, Vol.20 (1), p.155-160 |
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| creator | Ayez, Ninos Alberda, Wijnand J. Burger, Jacobus W. A. Eggermont, Alexander M. M. Nuyttens, Joost J. M. E. Dwarkasing, Roy S. Willemssen, François E. J. A. Verhoef, Cornelis |
| description | Background
There is no evidence regarding restaging of patients with locally advanced rectal cancer after a long course of neoadjuvant radiotherapy with or without chemotherapy. This study evaluated the value of restaging with chest and abdominal computed tomographic (CT) scan after radiotherapy.
Methods
Between January 2000 and December 2010, all newly diagnosed patients in our tertiary referral hospital, who underwent a long course of radiotherapy for locally advanced rectal cancer, were analyzed. Patients were only included if they had chest and abdominal imaging before and after radiotherapy treatment.
Results
A total of 153 patients who met the inclusion criteria and were treated with curative intent were included. A change in treatment strategy due to new findings on the CT scan after radiotherapy was observed in 18 (12 %) of 153 patients. Twelve patients (8 %) were spared rectal surgery due to progressive metastatic disease.
Conclusions
Restaging with a chest and abdominal CT scan after radiotherapy for locally advanced rectal cancer is advisable because additional findings may alter the treatment strategy. |
| doi_str_mv | 10.1245/s10434-012-2537-6 |
| format | Article |
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There is no evidence regarding restaging of patients with locally advanced rectal cancer after a long course of neoadjuvant radiotherapy with or without chemotherapy. This study evaluated the value of restaging with chest and abdominal computed tomographic (CT) scan after radiotherapy.
Methods
Between January 2000 and December 2010, all newly diagnosed patients in our tertiary referral hospital, who underwent a long course of radiotherapy for locally advanced rectal cancer, were analyzed. Patients were only included if they had chest and abdominal imaging before and after radiotherapy treatment.
Results
A total of 153 patients who met the inclusion criteria and were treated with curative intent were included. A change in treatment strategy due to new findings on the CT scan after radiotherapy was observed in 18 (12 %) of 153 patients. Twelve patients (8 %) were spared rectal surgery due to progressive metastatic disease.
Conclusions
Restaging with a chest and abdominal CT scan after radiotherapy for locally advanced rectal cancer is advisable because additional findings may alter the treatment strategy.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-012-2537-6</identifier><identifier>PMID: 22875644</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Adenocarcinoma - diagnostic imaging ; Adenocarcinoma - secondary ; Adenocarcinoma - therapy ; Aged ; Antimetabolites, Antineoplastic - therapeutic use ; Capecitabine ; Chemoradiotherapy, Adjuvant ; Colorectal Cancer ; Deoxycytidine - analogs & derivatives ; Deoxycytidine - therapeutic use ; Dose Fractionation ; Female ; Fluorouracil - analogs & derivatives ; Fluorouracil - therapeutic use ; Humans ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - secondary ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - secondary ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoadjuvant Therapy ; Neoplasm Staging ; Oncology ; Radiography, Abdominal ; Radiography, Thoracic ; Rectal Neoplasms - diagnostic imaging ; Rectal Neoplasms - pathology ; Rectal Neoplasms - therapy ; Rectum - surgery ; Retrospective Studies ; Surgery ; Surgical Oncology ; Tomography, X-Ray Computed</subject><ispartof>Annals of surgical oncology, 2013, Vol.20 (1), p.155-160</ispartof><rights>Society of Surgical Oncology 2012</rights><rights>Society of Surgical Oncology 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-5f36bfc05b08b5df68ca4485279d2b0bcca1f4f60ad3276c3ffaf27e6e4485d63</citedby><cites>FETCH-LOGICAL-c372t-5f36bfc05b08b5df68ca4485279d2b0bcca1f4f60ad3276c3ffaf27e6e4485d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-012-2537-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-012-2537-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22875644$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ayez, Ninos</creatorcontrib><creatorcontrib>Alberda, Wijnand J.</creatorcontrib><creatorcontrib>Burger, Jacobus W. A.</creatorcontrib><creatorcontrib>Eggermont, Alexander M. M.</creatorcontrib><creatorcontrib>Nuyttens, Joost J. M. E.</creatorcontrib><creatorcontrib>Dwarkasing, Roy S.</creatorcontrib><creatorcontrib>Willemssen, François E. J. A.</creatorcontrib><creatorcontrib>Verhoef, Cornelis</creatorcontrib><title>Is Restaging with Chest and Abdominal CT Scan after Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer Necessary?</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
There is no evidence regarding restaging of patients with locally advanced rectal cancer after a long course of neoadjuvant radiotherapy with or without chemotherapy. This study evaluated the value of restaging with chest and abdominal computed tomographic (CT) scan after radiotherapy.
Methods
Between January 2000 and December 2010, all newly diagnosed patients in our tertiary referral hospital, who underwent a long course of radiotherapy for locally advanced rectal cancer, were analyzed. Patients were only included if they had chest and abdominal imaging before and after radiotherapy treatment.
Results
A total of 153 patients who met the inclusion criteria and were treated with curative intent were included. A change in treatment strategy due to new findings on the CT scan after radiotherapy was observed in 18 (12 %) of 153 patients. Twelve patients (8 %) were spared rectal surgery due to progressive metastatic disease.
Conclusions
Restaging with a chest and abdominal CT scan after radiotherapy for locally advanced rectal cancer is advisable because additional findings may alter the treatment strategy.</description><subject>Adenocarcinoma - diagnostic imaging</subject><subject>Adenocarcinoma - secondary</subject><subject>Adenocarcinoma - therapy</subject><subject>Aged</subject><subject>Antimetabolites, Antineoplastic - therapeutic use</subject><subject>Capecitabine</subject><subject>Chemoradiotherapy, Adjuvant</subject><subject>Colorectal Cancer</subject><subject>Deoxycytidine - analogs & derivatives</subject><subject>Deoxycytidine - therapeutic use</subject><subject>Dose Fractionation</subject><subject>Female</subject><subject>Fluorouracil - analogs & derivatives</subject><subject>Fluorouracil - therapeutic use</subject><subject>Humans</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - secondary</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Lung Neoplasms - secondary</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoadjuvant Therapy</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Radiography, Abdominal</subject><subject>Radiography, Thoracic</subject><subject>Rectal Neoplasms - diagnostic imaging</subject><subject>Rectal Neoplasms - pathology</subject><subject>Rectal Neoplasms - therapy</subject><subject>Rectum - surgery</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Tomography, X-Ray Computed</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU1r3DAQhkVoyVfzA3opgl5ycatv2aeyLEkbWBJIk7OQ9bHrxba2kp2yp_z1SmxaQiEnzYwevaOZF4CPGH3BhPGvCSNGWYUwqQinshJH4BTzXGGixu9yjERdNUTwE3CW0hYhLCnix-CEkFpywdgpeL5J8N6lSa-7cQ1_d9MGLjc5h3q0cNHaMHSj7uHyAf40eoTaTy7CWxe03c5PepwKPYSobRemjYt6t4c-RLgKRvf9Hi5shoyzuYeZik7JioBxKem4__YBvPe6T-7i5TwHj9dXD8sf1eru-81ysaoMlWSquKei9QbxFtUtt17URjNWcyIbS1rUGqOxZ14gbSmRwlDvtSfSCVcoK-g5uDzo7mL4NecB1dAl4_pejy7MSWEiKRNEUJzRz_-h2zDHvIVCiYY1jeRNpvCBMjGkFJ1Xu9gNeSSFkSruqIM7KrujijuqfOLTi_LcDs7-e_HXjgyQA5Dy1bh28VXrN1X_AGqvms4</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Ayez, Ninos</creator><creator>Alberda, Wijnand J.</creator><creator>Burger, Jacobus W. A.</creator><creator>Eggermont, Alexander M. M.</creator><creator>Nuyttens, Joost J. M. E.</creator><creator>Dwarkasing, Roy S.</creator><creator>Willemssen, François E. J. A.</creator><creator>Verhoef, Cornelis</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>2013</creationdate><title>Is Restaging with Chest and Abdominal CT Scan after Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer Necessary?</title><author>Ayez, Ninos ; Alberda, Wijnand J. ; Burger, Jacobus W. A. ; Eggermont, Alexander M. M. ; Nuyttens, Joost J. M. E. ; Dwarkasing, Roy S. ; Willemssen, François E. J. A. ; Verhoef, Cornelis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-5f36bfc05b08b5df68ca4485279d2b0bcca1f4f60ad3276c3ffaf27e6e4485d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adenocarcinoma - diagnostic imaging</topic><topic>Adenocarcinoma - secondary</topic><topic>Adenocarcinoma - therapy</topic><topic>Aged</topic><topic>Antimetabolites, Antineoplastic - therapeutic use</topic><topic>Capecitabine</topic><topic>Chemoradiotherapy, Adjuvant</topic><topic>Colorectal Cancer</topic><topic>Deoxycytidine - analogs & derivatives</topic><topic>Deoxycytidine - therapeutic use</topic><topic>Dose Fractionation</topic><topic>Female</topic><topic>Fluorouracil - analogs & derivatives</topic><topic>Fluorouracil - therapeutic use</topic><topic>Humans</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - secondary</topic><topic>Lung Neoplasms - diagnostic imaging</topic><topic>Lung Neoplasms - secondary</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoadjuvant Therapy</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Radiography, Abdominal</topic><topic>Radiography, Thoracic</topic><topic>Rectal Neoplasms - diagnostic imaging</topic><topic>Rectal Neoplasms - pathology</topic><topic>Rectal Neoplasms - therapy</topic><topic>Rectum - surgery</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ayez, Ninos</creatorcontrib><creatorcontrib>Alberda, Wijnand J.</creatorcontrib><creatorcontrib>Burger, Jacobus W. A.</creatorcontrib><creatorcontrib>Eggermont, Alexander M. M.</creatorcontrib><creatorcontrib>Nuyttens, Joost J. M. E.</creatorcontrib><creatorcontrib>Dwarkasing, Roy S.</creatorcontrib><creatorcontrib>Willemssen, François E. J. A.</creatorcontrib><creatorcontrib>Verhoef, Cornelis</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ayez, Ninos</au><au>Alberda, Wijnand J.</au><au>Burger, Jacobus W. A.</au><au>Eggermont, Alexander M. M.</au><au>Nuyttens, Joost J. M. E.</au><au>Dwarkasing, Roy S.</au><au>Willemssen, François E. J. A.</au><au>Verhoef, Cornelis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is Restaging with Chest and Abdominal CT Scan after Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer Necessary?</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2013</date><risdate>2013</risdate><volume>20</volume><issue>1</issue><spage>155</spage><epage>160</epage><pages>155-160</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
There is no evidence regarding restaging of patients with locally advanced rectal cancer after a long course of neoadjuvant radiotherapy with or without chemotherapy. This study evaluated the value of restaging with chest and abdominal computed tomographic (CT) scan after radiotherapy.
Methods
Between January 2000 and December 2010, all newly diagnosed patients in our tertiary referral hospital, who underwent a long course of radiotherapy for locally advanced rectal cancer, were analyzed. Patients were only included if they had chest and abdominal imaging before and after radiotherapy treatment.
Results
A total of 153 patients who met the inclusion criteria and were treated with curative intent were included. A change in treatment strategy due to new findings on the CT scan after radiotherapy was observed in 18 (12 %) of 153 patients. Twelve patients (8 %) were spared rectal surgery due to progressive metastatic disease.
Conclusions
Restaging with a chest and abdominal CT scan after radiotherapy for locally advanced rectal cancer is advisable because additional findings may alter the treatment strategy.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>22875644</pmid><doi>10.1245/s10434-012-2537-6</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2013, Vol.20 (1), p.155-160 |
| issn | 1068-9265 1534-4681 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adenocarcinoma - diagnostic imaging Adenocarcinoma - secondary Adenocarcinoma - therapy Aged Antimetabolites, Antineoplastic - therapeutic use Capecitabine Chemoradiotherapy, Adjuvant Colorectal Cancer Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Dose Fractionation Female Fluorouracil - analogs & derivatives Fluorouracil - therapeutic use Humans Liver Neoplasms - diagnostic imaging Liver Neoplasms - secondary Lung Neoplasms - diagnostic imaging Lung Neoplasms - secondary Male Medicine Medicine & Public Health Middle Aged Neoadjuvant Therapy Neoplasm Staging Oncology Radiography, Abdominal Radiography, Thoracic Rectal Neoplasms - diagnostic imaging Rectal Neoplasms - pathology Rectal Neoplasms - therapy Rectum - surgery Retrospective Studies Surgery Surgical Oncology Tomography, X-Ray Computed |
| title | Is Restaging with Chest and Abdominal CT Scan after Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer Necessary? |
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