Positive and negative regulation of podoplanin expression by TGF-β and histone deacetylase inhibitors in oral and pharyngeal squamous cell carcinoma cell lines

Summary Objectives Podoplanin, a transmembrane sialomucin-like glycoprotein, is known to express at high frequency in oral squamous cell carcinomas (OSCC) and possess metastasis-promoting activity such as increased invasion and platelet-aggregating activity. However, the regulatory mechanism of podo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oral oncology 2013-01, Vol.49 (1), p.20-26
Hauptverfasser:	Ohta, Mitsuhiko, Abe, Atsushi, Ohno, Fumi, Hasegawa, Yasuhisa, Tanaka, Harunari, Maseki, Shinichiro, Kondo, Eisaku, Kurita, Kenichi, Nakanishi, Hayao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Animals Benzamides - pharmacology Biological and medical sciences Biomarkers, Tumor - analysis Butyrates - pharmacology Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - secondary Cell Differentiation - drug effects Cell Line, Tumor Dioxoles - pharmacology Female Hematology, Oncology and Palliative Medicine Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Humans Hydroxamic Acids - pharmacology Immunohistochemistry Keratin-10 - analysis Lymphatic Metastasis - pathology Male Medical sciences Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - drug effects Mice Mice, Nude Middle Aged Mouth Neoplasms - pathology Neoplasm Invasiveness Oral and pharyngeal squamous cell carcinomas Otolaryngology Otorhinolaryngology. Stomatology Pharyngeal Neoplasms - pathology Podoplanin Signal Transduction - drug effects Smad2 Protein - drug effects Squamous differentiation TGF-β Tongue Neoplasms - pathology Transforming Growth Factor beta - antagonists & inhibitors Transforming Growth Factor beta - pharmacology Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!