Pseudohyponatremia in Acute Liver Disease
Abstract Pseudohyponatremia secondary to hypercholesterolemia is a rare condition. In this study, the case of a 41-year-old woman who presented with acute hepatitis C virus infection and normal serum sodium and cholesterol concentrations is presented. Over the course of several weeks, she developed...
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| Veröffentlicht in: | The American journal of the medical sciences 2013, Vol.345 (1), p.62-64 |
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| container_title | The American journal of the medical sciences |
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| creator | Vo, Hieu, MD Garcia-Rosell, Melinda, MD Wall, Barry M., MD Gosmanov, Aidar R., MD, PhD |
| description | Abstract Pseudohyponatremia secondary to hypercholesterolemia is a rare condition. In this study, the case of a 41-year-old woman who presented with acute hepatitis C virus infection and normal serum sodium and cholesterol concentrations is presented. Over the course of several weeks, she developed jaundice due to biopsy-confirmed intrahepatic cholestasis and severe hyponatremia, as measured by indirect potentiometry. She was initially intensively treated for hyponatremia. Additional evaluation identified severe hypercholesterolemia, occurring in the absence of lipemic serum. Lipoprotein analysis was consistent with lipoprotein X. Measurement of plasma osmolality and serum sodium concentration using direct potentiometry confirmed the presence of pseudohyponatremia. With supportive care, cholestasis and associated jaundice resolved leading to resolution of both hypercholesterolemia and pseudohyponatremia. |
| doi_str_mv | 10.1097/MAJ.0b013e3182703327 |
| format | Article |
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In this study, the case of a 41-year-old woman who presented with acute hepatitis C virus infection and normal serum sodium and cholesterol concentrations is presented. Over the course of several weeks, she developed jaundice due to biopsy-confirmed intrahepatic cholestasis and severe hyponatremia, as measured by indirect potentiometry. She was initially intensively treated for hyponatremia. Additional evaluation identified severe hypercholesterolemia, occurring in the absence of lipemic serum. Lipoprotein analysis was consistent with lipoprotein X. Measurement of plasma osmolality and serum sodium concentration using direct potentiometry confirmed the presence of pseudohyponatremia. With supportive care, cholestasis and associated jaundice resolved leading to resolution of both hypercholesterolemia and pseudohyponatremia.</description><identifier>ISSN: 0002-9629</identifier><identifier>EISSN: 1538-2990</identifier><identifier>DOI: 10.1097/MAJ.0b013e3182703327</identifier><identifier>PMID: 23232812</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Cholestasis, Intrahepatic - etiology ; Diabetes Mellitus, Type 2 - complications ; Direct potentiometry ; Female ; Hepatitis C - blood ; Hepatitis C - complications ; Humans ; Hypercholesterolemia ; Hypercholesterolemia - blood ; Hypercholesterolemia - complications ; Hypercholesterolemia - diagnosis ; Hyponatremia - diagnosis ; Internal Medicine ; Lipoprotein X ; Plasma osmolality ; Pseudohyponatremia</subject><ispartof>The American journal of the medical sciences, 2013, Vol.345 (1), p.62-64</ispartof><rights>Southern Society for Clinical Investigation</rights><rights>2013 Southern Society for Clinical Investigation</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-1e5c05164301d69d7a5aad2ba2cf305c95ff5c7f1255e67882a0840fa2dbd0a23</citedby><cites>FETCH-LOGICAL-c417t-1e5c05164301d69d7a5aad2ba2cf305c95ff5c7f1255e67882a0840fa2dbd0a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23232812$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vo, Hieu, MD</creatorcontrib><creatorcontrib>Garcia-Rosell, Melinda, MD</creatorcontrib><creatorcontrib>Wall, Barry M., MD</creatorcontrib><creatorcontrib>Gosmanov, Aidar R., MD, PhD</creatorcontrib><title>Pseudohyponatremia in Acute Liver Disease</title><title>The American journal of the medical sciences</title><addtitle>Am J Med Sci</addtitle><description>Abstract Pseudohyponatremia secondary to hypercholesterolemia is a rare condition. In this study, the case of a 41-year-old woman who presented with acute hepatitis C virus infection and normal serum sodium and cholesterol concentrations is presented. Over the course of several weeks, she developed jaundice due to biopsy-confirmed intrahepatic cholestasis and severe hyponatremia, as measured by indirect potentiometry. She was initially intensively treated for hyponatremia. Additional evaluation identified severe hypercholesterolemia, occurring in the absence of lipemic serum. Lipoprotein analysis was consistent with lipoprotein X. Measurement of plasma osmolality and serum sodium concentration using direct potentiometry confirmed the presence of pseudohyponatremia. With supportive care, cholestasis and associated jaundice resolved leading to resolution of both hypercholesterolemia and pseudohyponatremia.</description><subject>Adult</subject><subject>Cholestasis, Intrahepatic - etiology</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Direct potentiometry</subject><subject>Female</subject><subject>Hepatitis C - blood</subject><subject>Hepatitis C - complications</subject><subject>Humans</subject><subject>Hypercholesterolemia</subject><subject>Hypercholesterolemia - blood</subject><subject>Hypercholesterolemia - complications</subject><subject>Hypercholesterolemia - diagnosis</subject><subject>Hyponatremia - diagnosis</subject><subject>Internal Medicine</subject><subject>Lipoprotein X</subject><subject>Plasma osmolality</subject><subject>Pseudohyponatremia</subject><issn>0002-9629</issn><issn>1538-2990</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtPwzAQhC0EouXxDxDqEQ4pu3YcJxekqrxVBBJwtlx7IwxpUuwEqf-eVAUOXNAe9jIzq_2GsSOEMUKhzu4nd2OYAwoSmHMFQnC1xYYoRZ7wooBtNgQAnhQZLwZsL8Y3AOQ5il024KKfHPmQnT5G6lzzulo2tWkDLbwZ-Xo0sV1Lo5n_pDC68JFMpAO2U5oq0uH33mcvV5fP05tk9nB9O53MEpuiahMkaUFilgpAlxVOGWmM43PDbSlA2kKWpbSqRC4lZSrPuYE8hdJwN3dguNhnJ5vcZWg-OoqtXvhoqapMTU0XNXIlUplhoXppupHa0MQYqNTL4BcmrDSCXkPSPST9F1JvO_6-0M0X5H5NP1R6wflGQP2fn56CjtZTbcn5QLbVrvH_XfgbYCtfe2uqd1pRfGu6UPcMNerINeindVHrnvryQGU5iC_w7InQ</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Vo, Hieu, MD</creator><creator>Garcia-Rosell, Melinda, MD</creator><creator>Wall, Barry M., MD</creator><creator>Gosmanov, Aidar R., MD, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2013</creationdate><title>Pseudohyponatremia in Acute Liver Disease</title><author>Vo, Hieu, MD ; Garcia-Rosell, Melinda, MD ; Wall, Barry M., MD ; Gosmanov, Aidar R., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-1e5c05164301d69d7a5aad2ba2cf305c95ff5c7f1255e67882a0840fa2dbd0a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Cholestasis, Intrahepatic - etiology</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Direct potentiometry</topic><topic>Female</topic><topic>Hepatitis C - blood</topic><topic>Hepatitis C - complications</topic><topic>Humans</topic><topic>Hypercholesterolemia</topic><topic>Hypercholesterolemia - blood</topic><topic>Hypercholesterolemia - complications</topic><topic>Hypercholesterolemia - diagnosis</topic><topic>Hyponatremia - diagnosis</topic><topic>Internal Medicine</topic><topic>Lipoprotein X</topic><topic>Plasma osmolality</topic><topic>Pseudohyponatremia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vo, Hieu, MD</creatorcontrib><creatorcontrib>Garcia-Rosell, Melinda, MD</creatorcontrib><creatorcontrib>Wall, Barry M., MD</creatorcontrib><creatorcontrib>Gosmanov, Aidar R., MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of the medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vo, Hieu, MD</au><au>Garcia-Rosell, Melinda, MD</au><au>Wall, Barry M., MD</au><au>Gosmanov, Aidar R., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pseudohyponatremia in Acute Liver Disease</atitle><jtitle>The American journal of the medical sciences</jtitle><addtitle>Am J Med Sci</addtitle><date>2013</date><risdate>2013</risdate><volume>345</volume><issue>1</issue><spage>62</spage><epage>64</epage><pages>62-64</pages><issn>0002-9629</issn><eissn>1538-2990</eissn><abstract>Abstract Pseudohyponatremia secondary to hypercholesterolemia is a rare condition. In this study, the case of a 41-year-old woman who presented with acute hepatitis C virus infection and normal serum sodium and cholesterol concentrations is presented. Over the course of several weeks, she developed jaundice due to biopsy-confirmed intrahepatic cholestasis and severe hyponatremia, as measured by indirect potentiometry. She was initially intensively treated for hyponatremia. Additional evaluation identified severe hypercholesterolemia, occurring in the absence of lipemic serum. Lipoprotein analysis was consistent with lipoprotein X. Measurement of plasma osmolality and serum sodium concentration using direct potentiometry confirmed the presence of pseudohyponatremia. With supportive care, cholestasis and associated jaundice resolved leading to resolution of both hypercholesterolemia and pseudohyponatremia.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23232812</pmid><doi>10.1097/MAJ.0b013e3182703327</doi><tpages>3</tpages></addata></record> |
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| ispartof | The American journal of the medical sciences, 2013, Vol.345 (1), p.62-64 |
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| source | MEDLINE; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Adult Cholestasis, Intrahepatic - etiology Diabetes Mellitus, Type 2 - complications Direct potentiometry Female Hepatitis C - blood Hepatitis C - complications Humans Hypercholesterolemia Hypercholesterolemia - blood Hypercholesterolemia - complications Hypercholesterolemia - diagnosis Hyponatremia - diagnosis Internal Medicine Lipoprotein X Plasma osmolality Pseudohyponatremia |
| title | Pseudohyponatremia in Acute Liver Disease |
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