A variant of the neuronal amino acid transporter SLC6A15 is associated with ACTH and cortisol responses and cognitive performance in unipolar depression

Major depressive disorder (MDD) is accompanied by both cognitive impairments and a hyperactivity of the hypothalamic–pituitary–adrenocortical (HPA) system, resulting in an enhanced glucocorticoid secretion. Cortisol acts via mineralocorticoid and glucocorticoid receptors densely located in the hippo...

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Veröffentlicht in:	The international journal of neuropsychopharmacology 2013-02, Vol.16 (1), p.83-90
Hauptverfasser:	Schuhmacher, Anna, Lennertz, Leonhard, Wagner, Michael, Höfels, Susanne, Pfeiffer, Ute, Guttenthaler, Vera, Maier, Wolfgang, Zobel, Astrid, Mössner, Rainald
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adrenocorticotropic Hormone - blood Adrenocorticotropic Hormone - secretion Adult Amino Acid Transport Systems, Neutral - genetics Biomarkers - blood Cognition - physiology Depressive Disorder - blood Depressive Disorder - genetics Female Genetic Variation - genetics Humans Hydrocortisone - blood Male Middle Aged Nerve Tissue Proteins - genetics Polymorphism, Single Nucleotide - genetics Young Adult
Online-Zugang:	Volltext
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