Widespread decreases in cortical muscarinic receptors in a subset of people with schizophrenia

These studies were undertaken to investigate the selectivity of cortical muscarinic receptor radioligand binding in muscarinic M1 and M4 receptor knockout mice and to determine whether a marked decrease in [3H]pirenzepine binding in Brodmann's area (BA) 9 from a subset of people with schizophre...

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Veröffentlicht in:	The international journal of neuropsychopharmacology 2013-02, Vol.16 (1), p.37-46
Hauptverfasser:	Gibbons, Andrew Stuart, Scarr, Elizabeth, Boer, Simone, Money, Tammie, Jeon, Won-Je, Felder, Chris, Dean, Brian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Cerebral Cortex - metabolism Cerebral Cortex - pathology Cohort Studies Female Humans Male Mice Mice, Knockout Middle Aged Muscarinic Antagonists - metabolism Pirenzepine - metabolism Protein Binding - physiology Radioligand Assay Radiopharmaceuticals - metabolism Receptor, Muscarinic M1 - metabolism Receptor, Muscarinic M4 - metabolism Schizophrenia - metabolism Schizophrenia - pathology Young Adult
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