New TFA-Free Cleavage and Final Deprotection in Fmoc Solid-Phase Peptide Synthesis: Dilute HCl in Fluoro Alcohol

A novel method for cleaving from resin and removing acid-labile protecting groups for the Fmoc solid-phase peptide synthesis is described. 0.1 N HCl in hexafluoroisopropanol or trifluoroethanol cleanly and rapidly removes the tert-butyl ester and ether, Boc, trityl, and Pbf groups and cleaves the co...

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Veröffentlicht in:	Organic letters 2012-12, Vol.14 (24), p.6346-6349
Hauptverfasser:	Palladino, Pasquale, Stetsenko, Dmitry A
Format:	Artikel
Sprache:	eng
Schlagworte:	Esters Molecular Structure Peptides - chemical synthesis Peptides - chemistry Resins, Synthetic - chemistry Solid-Phase Synthesis Techniques Trifluoroacetic Acid - chemistry
Online-Zugang:	Volltext
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