Essential role of toll-like receptor 4 in Acinetobacter baumannii-induced immune responses in immune cells

TLR4 is a membrane sensor for lipopolysaccharide (LPS), a major cell wall component of gram-negative bacteria. In this study, we investigated the role of TLR4 on innate immune responses in immune cells against Acinetobacter baumannii. Bone marrow-derived macrophages (BMDMs) and dendritic cells (BMDC...

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Veröffentlicht in:	Microbial pathogenesis 2013-01, Vol.54, p.20-25
Hauptverfasser:	Kim, Chang-Hwan, Jeong, Yu-Jin, Lee, Junglim, Jeon, Soo-Jin, Park, Se-Ra, Kang, Min-Jung, Park, Jae-Hak, Park, Jong-Hwan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinetobacter baumannii Acinetobacter baumannii - immunology Animals Apoptosis Bacteriology Biological and medical sciences Blotting, Western Cells, Cultured Cytokines Dendritic Cells - immunology Dendritic Cells - microbiology Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Gene Expression Profiling Immune response Interleukin-12 - secretion Interleukin-6 - secretion Macrophages - immunology Macrophages - microbiology Mice Mice, Inbred C57BL Mice, Knockout Microbiology Miscellaneous Mitogen-Activated Protein Kinase Kinases - biosynthesis NF-kappa B - biosynthesis Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type II - biosynthesis TLR4 Toll-Like Receptor 4 - deficiency Toll-Like Receptor 4 - immunology Tumor Necrosis Factor-alpha - secretion
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