Effects of IGF-1 on IL-1β-induced apoptosis in rabbit nucleus pulposus cells in vitro

Excessive apoptosis in intervertebral disc (IVD) cells is important in IVD degeneration. Interleukin (IL)-1β has been shown to induce apoptosis in these cells. However, whether insulin-like growth factor-1 (IGF-1) inhibits IL-1β-induced apoptosis in the nucleus pulposus remains unclear. The purpose...

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Veröffentlicht in:	Molecular medicine reports 2013-02, Vol.7 (2), p.441-444
Hauptverfasser:	ZHANG, CHANG-CHUN, ZHOU, JIAN-SHENG, HU, JIAN-GUO, WANG, XIANG, ZHOU, XIN-SHE, SUN, BAO-AN, SHAO, CHEN, LIN, QINGHUA
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Biotin Cell culture Cell death Cells, Cultured Collagen (type II) Cytokines Degeneration DNA nucleotidylexotransferase Enzymes Flow cytometry Glycosaminoglycans IL-1β Immunohistochemistry Insulin Insulin-like growth factor I Insulin-Like Growth Factor I - pharmacology insulin-like growth factor-1 Insulin-like growth factors Interleukin-1beta - pharmacology interleukin-1β Intervertebral Disc - cytology Intervertebral Disc - drug effects Intervertebral Disc - metabolism intervertebral disc degeneration Intervertebral discs Laboratory animals Microscopy Nuclei Nucleus pulposus Rabbits Toluidine
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