Application of Curcumin to Heart Failure Therapy by Targeting Transcriptional Pathway in Cardiomyocytes

Heart failure is one of the leading causes of death throughout the world. During the development and deterioration processes of heart failure, cardiomyocytes undergo maladaptive hypertrophy by altering hypertrophy-related gene expression. The zinc finger protein GATA4 is one of the transcription fac...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2013/01/01, Vol.36(1), pp.13-17
Hauptverfasser:	Katanasaka, Yasufumi, Sunagawa, Yoichi, Hasegawa, Koji, Morimoto, Tatsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiomegaly - genetics cardiomyocyte Cardiotonic Agents - pharmacology Cardiotonic Agents - therapeutic use curcumin Curcumin - pharmacology Curcumin - therapeutic use Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use GATA4 Heart Failure - drug therapy Heart Failure - genetics heart failure therapy Humans Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism p300 transcription Transcription, Genetic - drug effects
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