$Hepatitis B virus wild-type and rtN236T populations show similar early HBV DNA decline in adefovir refractory patients on a tenofovir-based regimen$

Hepatitis B virus wild-type and rtN236T populations show similar early HBV DNA decline in adefovir refractory patients on a tenofovir-based regimen

Hepatitis B virus (HBV) pol/RT mutations that confer clinical resistance to tenofovir disoproxil fumarate (TDF) have not been detected to date. In vitro, the rtN236T adefovir dipivoxil (ADV)‐associated resistance mutation confers low‐level cross‐resistance to tenofovir: 3‐ to 13‐fold changes in EC50...

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Veröffentlicht in:	Journal of viral hepatitis 2013-02, Vol.20 (2), p.131-140
Hauptverfasser:	Svarovskaia, E. S., Curtis, M., Zhu, Y., Borroto-Esoda, K., Miller, M. D., Berg, T., Lavocat, F., Zoulim, F., Kitrinos, K. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adefovir adefovir dipivoxil Adenine - analogs & derivatives Adenine - pharmacology Adenine - therapeutic use Adult allele-specific PCR Amino Acid Substitution Antiviral Agents - pharmacology Antiviral Agents - therapeutic use chronic hepatitis B Cross-resistance Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Deoxycytidine - therapeutic use Deoxyribonucleic acid Disease resistance DNA DNA, Viral - blood Double-Blind Method Drug Resistance, Viral Drug Therapy, Combination Emtricitabine Female Gene Products, pol - genetics Genetic Association Studies Hepatitis Hepatitis B virus Hepatitis B virus - drug effects Hepatitis B virus - enzymology Hepatitis B virus - genetics Hepatitis B, Chronic - blood Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - virology Humans Kinetics Male Microbiology Middle Aged Molecular Typing Mutation Organophosphonates - pharmacology Organophosphonates - therapeutic use Polymerase Chain Reaction Randomized Controlled Trials as Topic rtN236T Sequence Analysis, DNA Statistical analysis Tenofovir tenofovir DF Treatment Outcome Viral Load Virus Replication Viruses
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