Reduced brain-derived neurotrophic factor (BDNF) mRNA expression and presence of BDNF-immunoreactive granules in the spinocerebellar ataxia type 6 (SCA6) cerebellum

Spinocerebellar ataxia type 6 (SCA6) is an autosomal‐dominant neurodegenerative disorder caused by a small expansion of tri‐nucleotide (CAG) repeat encoding polyglutamine (polyQ) in the gene for α1A voltage‐dependent calcium channel (Cav2.1). Thus, this disease is one of the nine neurodegenerative d...

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Veröffentlicht in:	Neuropathology 2012-12, Vol.32 (6), p.595-603
Hauptverfasser:	Takahashi, Makoto, Ishikawa, Kinya, Sato, Nozomu, Obayashi, Masato, Niimi, Yusuke, Ishiguro, Taro, Yamada, Mitsunori, Toyoshima, Yasuko, Takahashi, Hitoshi, Kato, Takeo, Takao, Masaki, Murayama, Shigeo, Mori, Osamu, Eishi, Yoshinobu, Mizusawa, Hidehiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Brain-derived neurotrophic factor brain-derived neurotrophic factor (BDNF) Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Calcium channels (voltage-gated) Cerebellum Cerebellum - metabolism Cerebellum - pathology Cytoplasm Cytoplasm - metabolism Dendrites Female Gene expression Gene Expression Regulation Granules Humans Huntington's disease Immunohistochemistry Male Middle Aged Neurodegenerative diseases Neuropathology polyglutamine diseases Polymerase chain reaction Protein transport Purkinje cell Purkinje cells Purkinje Cells - metabolism Purkinje Cells - pathology quantitative reverse transcription PCR (qRT-PCR) RNA, Messenger - biosynthesis Spinocerebellar ataxia spinocerebellar ataxia type 6 (SCA6) Spinocerebellar Ataxias - genetics Spinocerebellar Ataxias - metabolism Spinocerebellar Ataxias - pathology trinucleotide repeat diseases
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