Aryl Hydrocarbon Receptor Repressor (AhRR) Function Revisited: Repression of CYP1 Activity in Human Skin Fibroblasts Is Not Related to AhRR Expression

The skin reacts to environmental noxae by inducing cytochrome P450 (CYP)-catalyzed reactions via activation of the aryl hydrocarbon receptor (AhR). A drawback of this response is the generation of oxidative stress, which is especially dangerous for postreplicative cells such as dermal fibroblasts, i...

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Veröffentlicht in:	Journal of investigative dermatology 2013-01, Vol.133 (1), p.87-96
Hauptverfasser:	Tigges, Julia, Weighardt, Heike, Wolff, Sandra, Götz, Christine, Förster, Irmgard, Kohne, Zippora, Huebenthal, Ulrike, Merk, Hans F., Abel, Josef, Haarmann-Stemmann, Thomas, Krutmann, Jean, Fritsche, Ellen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Basic Helix-Loop-Helix Transcription Factors - biosynthesis Benzo(a)pyrene - pharmacology Cells, Cultured Cytochrome P-450 CYP1A1 - genetics Cytochrome P-450 CYP1A1 - metabolism Female Fibroblasts - drug effects Fibroblasts - metabolism Gene Expression Regulation - drug effects Histone Deacetylase Inhibitors - pharmacology Humans Hydroxamic Acids - pharmacology Methylcholanthrene - pharmacology Mice Middle Aged Promoter Regions, Genetic Receptors, Aryl Hydrocarbon - agonists Repressor Proteins - biosynthesis Skin - drug effects Skin - metabolism Young Adult
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